PubRank

Amyotrophic Lateral Sclerosis and the Innate Immune System

Clinical Trial ID NCT02869048

PubWeight™ 0.00‹?›

🔗 Visit the ClinicalTrials.gov page for NCT02869048

Top papers

Rank Title Journal Year PubWeight™‹?›
1 El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000 15.38
2 Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 2004 6.26
3 Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat Neurosci 2006 3.56
4 Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol 2007 3.16
5 Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci 2000 3.14
6 Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat Rev Neurol 2011 2.55
7 Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2012 2.49
8 Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci 1998 2.48
9 Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study. Lancet Neurol 2013 2.46
10 Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 1992 2.01
11 Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc Natl Acad Sci U S A 2007 1.79
12 Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology 2013 1.76
13 The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol 2008 1.52
14 Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis. J Neuroinflammation 2013 1.21
15 C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A 2013 1.17
16 Amyotrophic lateral sclerosis: effect of serum on anterior horn cells in tissue culture. Science 1973 1.03
17 High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients. Acta Neurol Scand 1985 1.01
18 Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation. Neurobiol Dis 2011 1.01
19 Serum and CSF immunological findings in ALS. Acta Neurol Scand 1991 0.98
20 Age-period-cohort analysis of trends in amyotrophic lateral sclerosis in Denmark, 1970-2009. Am J Epidemiol 2013 0.96
21 Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1994 0.94
22 Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. Biochem Biophys Res Commun 2006 0.93
23 C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neurosci Lett 1999 0.88
24 Motor unit behavior in canine motor neuron disease. J Neurosci 1995 0.88
25 Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis. J Neuroimmunol 2011 0.85
26 Neuron specific in vitro cytotoxicity of sera from patients with amyotrophic lateral sclerosis. Muscle Nerve 1982 0.83
27 Novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS. Neurobiol Aging 2011 0.82
28 The effect of serum from ALS patients on organotypic nerve and muscle tissue cultures. Acta Neuropathol 1975 0.79
29 Cultured rat spinal cord neurons: interaction with motor neuron disease immunoglobulins. Muscle Nerve 1985 0.78
30 Nature and properties of cytotoxic plasma activity in amyotrophic lateral sclerosis. Muscle Nerve 1987 0.75
31 Cytotoxic activity in plasma from patients with amyotrophic lateral sclerosis. Neurology 1991 0.75
32 Cytotoxic activity in the plasma of amyotrophic lateral sclerosis (ALS) patients against normal erythrocytes. Quantitative determinations. J Neurol Sci 1985 0.75
33 Immunoglobulin-mediated cytotoxic effect of ALS-plasma towards erythrocytes: reflexion of a pathogenetic mechanism? Adv Exp Med Biol 1987 0.75
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