A 6-week Dose Ranging Study of CHF 5259 pMDI in Subjects With Chronic Obstructive Pulmonary Disease

Clinical Trial ID NCT03084796

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 56.72
2 Standardisation of spirometry. Eur Respir J 2005 48.20
3 A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008 17.19
4 Development and first validation of the COPD Assessment Test. Eur Respir J 2009 8.06
5 Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 2007 5.51
6 The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984 5.19
7 Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD. N Engl J Med 2016 4.51
8 Hospitalizations and mortality in the Lung Health Study. Am J Respir Crit Care Med 2002 4.11
9 COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002 3.34
10 Minimal clinically important differences in COPD lung function. COPD 2005 3.00
11 Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD. Thorax 2010 2.79
12 Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the multi-ethnic study of atherosclerosis (MESA) lung study. Chest 2009 2.65
13 Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. Thorax 2011 2.59
14 Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2014 2.41
15 Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012 2.21
16 Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest 2009 2.20
17 Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial. Lancet 2016 2.19
18 Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J 2009 2.11
19 Efficacy and safety of NVA237 versus placebo and tiotropium in patients with COPD: the GLOW2 study. Eur Respir J 2012 1.98
20 The efficiency of simulation-based multiple comparisons. Biometrics 1987 1.91
21 Efficacy and safety of once-daily NVA237 in patients with moderate-to-severe COPD: the GLOW1 trial. Respir Res 2011 1.89
22 The safety of tiotropium--the FDA's conclusions. N Engl J Med 2010 1.85
23 Minimal important difference of the transition dyspnoea index in a multinational clinical trial. Eur Respir J 2003 1.84
24 Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 2005 1.83
25 The local side effects of inhaled corticosteroids: current understanding and review of the literature. Chest 2004 1.76
26 Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysis. Ann Allergy Asthma Immunol 2007 1.74
27 Inhaled corticosteroids and the risks of diabetes onset and progression. Am J Med 2010 1.66
28 Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2007 1.58
29 Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study, a randomised controlled trial. Thorax 2015 1.55
30 Creating scenarios of the impact of COPD and their relationship to COPD Assessment Test (CAT™) scores. BMC Pulm Med 2011 1.54
31 Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial. Int J Chron Obstruct Pulmon Dis 2012 1.52
32 FLIGHT1 and FLIGHT2: Efficacy and Safety of QVA149 (Indacaterol/Glycopyrrolate) versus Its Monocomponents and Placebo in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2015 1.51
33 Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis. Thorax 2012 1.48
34 Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax 2008 1.47
35 Relationship between salivary flow rates and Candida counts in subjects with xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 1.45
36 Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Respir Res 2013 1.13
37 Use of inhaled and oral corticosteroids and the long-term risk of cataract. Ophthalmology 2009 1.13
38 Smoking cessation and COPD. Eur Respir Rev 2013 1.09
39 Tiotropium bromide inhalation powder: a review of its use in the management of chronic obstructive pulmonary disease. Drugs 2012 1.09
40 Long-acting beta2-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2013 1.07
41 Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. Respir Med 2011 1.05
42 Acceptability and reproducibility criteria of the American Thoracic Society as observed in a sample of the general population. Am Rev Respir Dis 1991 1.02
43 Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients. Int J Chron Obstruct Pulmon Dis 2008 1.01
44 Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis. Int J Chron Obstruct Pulmon Dis 2013 1.01
45 Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials. Respir Res 2014 0.99
46 Measuring respiratory symptoms in clinical trials of COPD: reliability and validity of a daily diary. Thorax 2014 0.98
47 Inhalational and topical steroids, and oral candidosis: a mini review. Oral Dis 2001 0.95
48 Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD. Int J Chron Obstruct Pulmon Dis 2012 0.89
49 Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease. BMC Pulm Med 2014 0.89
50 Skin manifestations of inhaled corticosteroids in COPD patients: results from Lung Health Study II. Chest 2004 0.89
51 Bone mineral density in patients with chronic obstructive pulmonary disease treated with budesonide Turbuhaler. Eur Respir J 2002 0.87
52 One-Year Safety of Olodaterol Once Daily via Respimat® in Patients with GOLD 2-4 Chronic Obstructive Pulmonary Disease: Results of a Pre-Specified Pooled Analysis. COPD 2015 0.87
53 Ipratropium bromide hydrofluoroalkane inhalation aerosol is safe and effective in patients with COPD. Chest 2001 0.86
54 Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD. Ann Am Thorac Soc 2015 0.85
55 A novel model-based approach for dose determination of glycopyrronium bromide in COPD. BMC Pulm Med 2012 0.85
56 Daily variation in lung function in COPD patients with combined albuterol and ipratropium: results from a 4-week, randomized, crossover study. Pulm Pharmacol Ther 2014 0.82
57 Safety and tolerability of inhalational anticholinergics in COPD. Drug Healthc Patient Saf 2013 0.82
58 Long-term use of fluticasone propionate/salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database. Int J Chron Obstruct Pulmon Dis 2011 0.81
59 Efficacy and Safety of Umeclidinium Added to Fluticasone Propionate/Salmeterol in Patients with COPD: Results of Two Randomized, Double-Blind Studies. COPD 2015 0.81
60 Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients. Int J Chron Obstruct Pulmon Dis 2012 0.80
61 Efficacy and safety of twice-daily glycopyrrolate in patients with stable, symptomatic COPD with moderate-to-severe airflow limitation: the GEM1 study. Int J Chron Obstruct Pulmon Dis 2016 0.78
62 Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis. Lancet Respir Med 2016 0.76
63 Smoking cessation for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2016 0.76
64 Long-term safety of glycopyrrolate: A randomized study in patients with moderate-to-severe COPD (GEM3). Respir Med 2016 0.75
65 Efficacy and Safety of Twice-Daily Glycopyrrolate Versus Placebo in Patients With COPD: The GEM2 Study. Chronic Obstr Pulm Dis 2016 0.75
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