Circulating Tumor DNA (ctDNA) as a Prognostic Tool in Patients With Advanced Lung Adenocarcinoma

Clinical Trial ID NCT03090815

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cancer statistics, 2012. CA Cancer J Clin 2012 87.38
2 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009 46.35
3 Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011 16.94
4 Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013 14.78
5 Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 2008 13.54
6 Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013 13.22
7 The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 2012 10.17
8 Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol 2011 8.40
9 Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med 2014 8.36
10 Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013 7.42
11 Lung cancer in never smokers: a review. J Clin Oncol 2007 5.49
12 An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med 2014 4.98
13 Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol 2014 4.76
14 Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res 2006 4.72
15 A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol 2014 4.54
16 Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011 4.16
17 Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis. J Natl Cancer Inst 2013 3.63
18 Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease. J Clin Oncol 2013 2.90
19 ALK in lung cancer: past, present, and future. J Clin Oncol 2013 2.70
20 Survival in early-stage non-small cell lung cancer. Ann Thorac Surg 1995 2.01
21 Detection and Dynamic Changes of EGFR Mutations from Circulating Tumor DNA as a Predictor of Survival Outcomes in NSCLC Patients Treated with First-line Intercalated Erlotinib and Chemotherapy. Clin Cancer Res 2015 1.59
22 Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation--diversity, ductility, and destiny. Cancer Metastasis Rev 2012 1.32
23 Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers. PLoS One 2012 1.27
24 Diagnostic Accuracy of Noninvasive Genotyping of EGFR in Lung Cancer Patients by Deep Sequencing of Plasma Cell-Free DNA. Clin Chem 2015 1.20
25 EGFR-targeted therapy for non-small cell lung cancer: focus on EGFR oncogenic mutation. Int J Med Sci 2013 1.14
26 Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: A meta-analysis from six phase III randomized controlled trials. Int J Cancer 2012 1.08
27 EGFR array: uses in the detection of plasma EGFR mutations in non-small cell lung cancer patients. J Thorac Oncol 2012 1.07
28 Treatment of lung cancer. Radiol Clin North Am 2012 0.98
29 Epidermal growth factor receptor mutation status in stage I lung adenocarcinoma with different image patterns. J Thorac Oncol 2011 0.93
30 Circulating Tumor DNA Outperforms Circulating Tumor Cells for KRAS Mutation Detection in Thoracic Malignancies. Clin Chem 2015 0.91
31 Plasma EGFR Mutation Detection Associated With Survival Outcomes in Advanced-Stage Lung Cancer. Clin Lung Cancer 2015 0.78
32 Overcoming acquired resistance to kinase inhibition: the cases of EGFR, ALK and BRAF. Bioorg Med Chem Lett 2012 0.77
33 ALK-mutated non-small-cell lung cancer: a new strategy for cancer treatment. Lung 2012 0.77
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