PubRank

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects (RESET-YOUTH)

Clinical Trial ID NCT03353597

PubWeight™ 0.00‹?›

🔗 Visit the ClinicalTrials.gov page for NCT03353597

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A C. elegans mutant that lives twice as long as wild type. Nature 1993 20.42
2 Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007 16.55
3 The genetics of ageing. Nature 2010 12.08
4 A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 2011 11.33
5 Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005 11.23
6 Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003 10.56
7 Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011 8.45
8 Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004 8.30
9 Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007 8.07
10 DNA methylation age of human tissues and cell types. Genome Biol 2013 7.48
11 Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009 7.07
12 The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011 6.71
13 Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 2012 6.50
14 Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 2009 6.42
15 Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 2010 6.03
16 Notch-mediated restoration of regenerative potential to aged muscle. Science 2003 5.99
17 The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell 2002 5.70
18 Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 1999 4.91
19 The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol 2010 4.25
20 Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012 4.05
21 Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2008 3.93
22 Stem cells, ageing and the quest for immortality. Nature 2006 3.89
23 Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 2014 3.75
24 Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 2004 3.56
25 Epigenetic predictor of age. PLoS One 2011 3.46
26 Epigenetics and aging: the targets and the marks. Trends Genet 2007 3.44
27 Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 2014 3.37
28 Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012 3.05
29 Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell 2012 2.91
30 Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 2017 2.71
31 Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet 2011 2.62
32 DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol 2015 2.51
33 The reliability theory of aging and longevity. J Theor Biol 2001 2.48
34 Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009 2.21
35 Longitudinal changes in forced expiratory volume in one second in adults. Methodologic considerations and findings in healthy nonsmokers. Am Rev Respir Dis 1986 2.18
36 Tissue-specific dysregulation of DNA methylation in aging. Aging Cell 2010 1.90
37 Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle 2005 1.79
38 Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. Nat Commun 2015 1.70
39 Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) 2011 1.55
40 Age-related changes in osteogenic stem cells in mice. J Bone Miner Res 1996 1.42
41 Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell 2013 1.33
42 Lung function in healthy never smoking adults: reference values and lower limits of normal of a Swiss population. Thorax 1996 1.26
43 DNA methylation age is associated with mortality in a longitudinal Danish twin study. Aging Cell 2015 1.25
44 Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol 2015 1.24
45 The influence of aging on muscle strength and muscle fiber characteristics with special reference to eccentric strength. J Gerontol A Biol Sci Med Sci 1995 1.23
46 Age-related decrements in Stroop Color Test performance. J Clin Psychol 1984 1.19
47 Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci 2014 1.15
48 Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning. Aging (Albany NY) 2015 1.14
49 Age effects on executive ability. Neuropsychology 2000 1.08
50 DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY) 2016 1.08
51 Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenetics 2016 1.05
52 Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet 2012 0.92
53 Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nat Biotechnol 2016 0.89
54 A revival of parabiosis in biomedical research. Swiss Med Wkly 2014 0.78
55 Cloning and sequencing of the cDNA encoding lipase I from Trichosporon fermentans WU-C12. FEMS Microbiol Lett 1997 0.76
56 Dynamics of epigenetic age following hematopoietic stem cell transplantation. Haematologica 2017 0.75
57 A pilot investigation of the impact of smoking cessation on biological age. Am J Addict 2017 0.75
58 [A study of the absorption of vapors of I-131 compounds by the human skin]. Med Radiol (Mosk) 1967 0.75
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