Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation (LateAna)

Clinical Trial ID NCT03513458

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 The interleukin-1 family: back to the future. Immunity 2013 3.90
2 Economic burden of asthma: a systematic review. BMC Pulm Med 2009 3.10
3 Risk of infectious complications in patients taking glucocorticosteroids. Rev Infect Dis 1990 2.42
4 National surveillance of asthma: United States, 2001-2010. Vital Health Stat 3 2012 2.18
5 IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers. J Allergy Clin Immunol 2014 2.17
6 Asthma exacerbations: origin, effect, and prevention. J Allergy Clin Immunol 2011 2.09
7 Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics 1993 1.80
8 The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. Am J Pathol 1991 1.58
9 Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med 1997 1.55
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11 Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages. J Immunol 2010 1.37
12 The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun 2015 1.09
13 Effect of interleukin-1 beta on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats. J Allergy Clin Immunol 1994 1.06
14 Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma. Chest 2014 1.00
15 Potential role of interleukin-1 in allergen-induced late asthmatic reactions in guinea pigs: suppressive effect of interleukin-1 receptor antagonist on late asthmatic reaction. J Allergy Clin Immunol 1995 0.98
16 Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther 2006 0.94
17 Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS One 2013 0.91
18 Childhood asthma hospitalizations in the United States, 2000-2009. J Pediatr 2013 0.88
19 IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone. Am J Physiol Lung Cell Mol Physiol 2014 0.86
20 Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. Am J Respir Cell Mol Biol 2012 0.85
21 Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi. Eur J Pharmacol 1999 0.81
22 Asthma: Hospitalization Trends and Predictors of In-Hospital Mortality and Hospitalization Costs in the USA (2001-2010). Int Arch Allergy Immunol 2015 0.78
23 The acute effects of corticosteroids in bronchial asthma. Eur J Respir Dis Suppl 1982 0.75
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