PubRank

SNIFF - 3-Week Aptar CPS Device

Clinical Trial ID NCT05006599

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🔗 Visit the ClinicalTrials.gov page for NCT05006599

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001 76.04
2 The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011 21.80
3 A new clinical scale for the staging of dementia. Br J Psychiatry 1982 21.77
4 A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006 21.56
5 Current concepts in mild cognitive impairment. Arch Neurol 2001 18.09
6 The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006 13.48
7 A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992 11.25
8 An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997 5.94
9 Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 2008 5.29
10 Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2011 4.76
11 Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 2002 4.70
12 Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2007 4.14
13 Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 2004 3.67
14 Clinical dementia rating training and reliability in multicenter studies: the Alzheimer's Disease Cooperative Study experience. Neurology 1997 3.53
15 Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 2010 3.08
16 Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004 2.86
17 Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med 1994 2.76
18 Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 1998 2.61
19 Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009 2.50
20 Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 2008 2.25
21 Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2005 2.15
22 Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005 2.12
23 Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J Alzheimers Dis 2008 2.08
24 Intranasal insulin improves memory in humans. Psychoneuroendocrinology 2004 2.03
25 Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001 1.95
26 Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 2007 1.95
27 Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. Br Med J (Clin Res Ed) 1982 1.90
28 Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm (Vienna) 1998 1.90
29 Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 1997 1.88
30 Preserved pontine glucose metabolism in Alzheimer disease: a reference region for functional brain image (PET) analysis. J Comput Assist Tomogr 1995 1.88
31 Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res 1995 1.65
32 Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci 2004 1.62
33 Retracted Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 1.60
34 Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta 2008 1.56
35 Development of short forms from the PROMIS™ sleep disturbance and Sleep-Related Impairment item banks. Behav Sleep Med 2011 1.45
36 Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab 2008 1.42
37 Neuronal dynamics and axonal flow, ii. The olfactory nerve as model test object. Proc Natl Acad Sci U S A 1967 1.37
38 Nasal drug delivery: new developments and strategies. Drug Discov Today 2002 1.34
39 Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch Neurol 2005 1.33
40 Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 1986 1.29
41 Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav 2004 1.17
42 Transport of molecules from nose to brain: transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium. Brain Res Bull 1985 1.13
43 Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol Aging 2007 1.11
44 Obese men respond to cognitive but not to catabolic brain insulin signaling. Int J Obes (Lond) 2007 1.11
45 Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 1999 1.04
46 Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults. Diabetes Metab Res Rev 2003 1.02
47 Endocytic and exocytic pathways of the neuronal secretory process and trans-synaptic transfer of wheat germ agglutinin-horseradish peroxidase in vivo. J Comp Neurol 1985 1.00
48 Uptake of exogenous proteins in mouse olfactory cells. Acta Neuropathol 1971 1.00
49 Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat. Exp Brain Res 1986 0.94
50 Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease. Alzheimer Dis Assoc Disord 2011 0.93
51 Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the molecular weight of drugs. J Pharm Pharmacol 1995 0.89
52 Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease. J Alzheimers Dis 2010 0.88
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