Published in Oncogene on December 31, 1998
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell (2011) 2.84
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol (2005) 2.57
Structure and function of the C-terminal PABC domain of human poly(A)-binding protein. Proc Natl Acad Sci U S A (2001) 1.99
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol (2009) 1.79
A novel role for RIP1 kinase in mediating TNFα production. Cell Death Dis (2012) 1.67
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature (2014) 1.66
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J (2006) 1.64
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. EMBO J (2003) 1.52
X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proc Natl Acad Sci U S A (2001) 1.40
The substrate recognition domains of the N-end rule pathway. J Biol Chem (2008) 1.31
Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol (2004) 1.28
HECT E3s and human disease. BMC Biochem (2007) 1.19
EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem (2011) 1.17
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell (2010) 1.15
Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem (2013) 1.11
Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. Mol Cell (2011) 1.06
The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br J Cancer (2008) 1.02
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A (2011) 0.99
Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. RNA (2006) 0.96
Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. J Biol Chem (2010) 0.96
UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. Proc Natl Acad Sci U S A (2014) 0.95
Modulation of myocardin function by the ubiquitin E3 ligase UBR5. J Biol Chem (2010) 0.93
EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer. Carcinogenesis (2013) 0.90
Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD. J Virol (2011) 0.85
The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. Biochim Biophys Acta (2012) 0.84
E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. Oncogene (2015) 0.81
Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD. PLoS One (2015) 0.78
The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding. J Biol Chem (2015) 0.77
Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop. PLoS Genet (2015) 0.76
Harnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay. Sci Rep (2016) 0.75
UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans. G3 (Bethesda) (2016) 0.75
UBR5 Gene Mutation Is Associated with Familial Adult Myoclonic Epilepsy in a Japanese Family. ISRN Neurol (2012) 0.75
E3 ubiquitin ligase isolated by differential display regulates cervical cancer growth in vitro and in vivo via microRNA-143. Exp Ther Med (2016) 0.75
The p90 ribosomal S6 kinase-UBR5 pathway controls toll-like receptor signaling via miRNA-induced translational inhibition of TNF receptor-associated factor 3. J Biol Chem (2017) 0.75
Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity (1995) 10.59
Open access echocardiography in management of heart failure in the community. BMJ (1995) 7.83
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Science (1991) 5.99
Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture. Am J Hum Genet (1979) 5.18
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet (1998) 4.91
Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium. Science (1977) 4.59
Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics. Am J Hum Genet (1979) 4.10
Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet (2001) 3.83
Expression and amplification of cyclin genes in human breast cancer. Oncogene (1993) 3.79
Safety of transesophageal echocardiography. A multicenter survey of 10,419 examinations. Circulation (1991) 3.70
Dynamic mutations: a new class of mutations causing human disease. Cell (1992) 3.63
Value of the electrocardiogram in identifying heart failure due to left ventricular systolic dysfunction. BMJ (1996) 3.59
Brief report: fulminating fat embolism syndrome caused by paradoxical embolism through a patent foramen ovale. N Engl J Med (1993) 3.55
Further segregation analysis of the fragile X syndrome with special reference to transmitting males. Hum Genet (1985) 3.42
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet (1976) 3.41
Regional strain and strain rate measurements by cardiac ultrasound: principles, implementation and limitations. Eur J Echocardiogr (2000) 3.36
Incidence and origin of "null" alleles in the (AC)n microsatellite markers. Am J Hum Genet (1993) 3.18
A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet (1995) 3.15
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell (1993) 2.73
Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol (2000) 2.66
Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet (2000) 2.56
DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity (1996) 2.56
Conference report: International Workshop on the fragile X and X-linked mental retardation. Am J Med Genet (1984) 2.49
Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem (1997) 2.40
Unnecessary x ray examinations. BMJ (1989) 2.37
Simple repeat DNA is not replicated simply. Nat Genet (1994) 2.37
Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci U S A (1994) 2.29
X-linked mental retardation with macro-orchidism and the fragile site at Xq 27 or 28. Hum Genet (1979) 2.12
Ventricular septal defects. Two dimensional echocardiographic and morphological correlations. Br Heart J (1982) 2.11
Diagnosis of heart tumours by transoesophageal echocardiography: a multicentre study in 154 patients. European Cooperative Study Group. Eur Heart J (1993) 2.10
Assignment of anonymous DNA probes to specific intervals of human chromosomes 16 and X. Hum Genet (1989) 2.10
Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells. Endocr Relat Cancer (2003) 2.06
Dynamic mutation: possible mechanisms and significance in human disease. Trends Biochem Sci (1997) 2.04
Progestin regulation of cellular proliferation. Endocr Rev (1990) 2.04
Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.01
Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16. Genomics (1992) 2.00
Non-invasive diagnosis of coronary artery disease by quantitative stress echocardiography: optimal diagnostic models using off-line tissue Doppler in the MYDISE study. Eur Heart J (2003) 1.99
c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol Cell Biol (1998) 1.97
Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers. Am J Hum Genet (1991) 1.95
Theatre over-shoes do not reduce operating theatre floor bacterial counts. J Hosp Infect (1991) 1.92
Fragile X syndrome without CCG amplification has an FMR1 deletion. Nat Genet (1992) 1.91
Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression. Am J Hum Genet (1980) 1.88
bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene (1996) 1.87
Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem (2001) 1.86
Localization of a gene for autosomal dominant nocturnal frontal lobe epilepsy to chromosome 20q 13.2. Nat Genet (1995) 1.86
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci U S A (1999) 1.86
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity (1997) 1.85
Policy for prevention of Asian rickets in Britain: a preliminary assessment of the Glasgow rickets campaign. Br Med J (Clin Res Ed) (1981) 1.83
Frequent loss of estrogen receptor-beta expression in prostate cancer. Cancer Res (2001) 1.77
Coherence between low-frequency activation of the motor cortex and tremor in patients with essential tremor. Lancet (2000) 1.72
Explanation for exclusive maternal origin for congenital form of myotonic dystrophy. Lancet (1993) 1.72
Rational modification of enzyme catalysis by engineering surface charge. Nature (1987) 1.71
Fragile X syndrome: genetic localisation by linkage mapping of two microsatellite repeats FRAXAC1 and FRAXAC2 which immediately flank the fragile site. J Med Genet (1991) 1.71
Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol (1999) 1.70
Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol (1999) 1.70
Mapping the short arm of human chromosome 16. Genomics (1989) 1.69
Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry (2008) 1.67
Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring. Neurology (2003) 1.67
The detection of fat embolism by transoesophageal echocardiography during reamed intramedullary nailing. A study of 24 patients with femoral and tibial fractures. J Bone Joint Surg Br (1993) 1.66
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol Cell Biol (1993) 1.65
Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells. Cancer Res (1983) 1.65
Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clin Cancer Res (1999) 1.65
Anatomical basis of cross sectional echocardiography. Br Heart J (1983) 1.63
Down's syndrome in South Australia. Med J Aust (1979) 1.63
The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol (1994) 1.63
Effects of mechanical signaling on plant cell cytosolic calcium. Proc Natl Acad Sci U S A (1995) 1.63
Diagnosis of atrial situs by transesophageal echocardiography. J Am Coll Cardiol (1990) 1.62
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim. Mamm Genome (2001) 1.62
Identification of the gene FMR2, associated with FRAXE mental retardation. Nat Genet (1996) 1.61
Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol (1994) 1.59
Prevention of rickets in Asian children: assessment of the Glasgow campaign. Br Med J (Clin Res Ed) (1985) 1.58
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. Br J Cancer (2009) 1.57
Partial and complete trisomy 9: delineation of a trisomy 9 syndrome. Hum Genet (1976) 1.56
Transesophageal echocardiographic monitoring of interventional cardiac catheterization in children. J Am Coll Cardiol (1991) 1.56
Fine mapping of gene probes and anonymous DNA fragments to the long arm of chromosome 16. Genomics (1988) 1.55
Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Cell (1997) 1.55
Heritable fragile sites on human chromosomes. VII. Children homozygous for the BrdU-requiring fra(10)(q25) are phenotypically normal. Am J Hum Genet (1981) 1.55
Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res (1999) 1.52
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J (1994) 1.52
Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J Biol Chem (1996) 1.52
Heritable fragile sites on human chromosomes. III. Detection of fra(X)(q27) in males with X-linked mental retardation and in their female relatives. Hum Genet (1979) 1.51
Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis. Science (1994) 1.51
At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer. Genes Chromosomes Cancer (1994) 1.50
High frame rate myocardial integrated backscatter. Does this change our understanding of this acoustic parameter? Eur J Echocardiogr (2000) 1.49
Tamoxifen induces accumulation of MCF 7 human mammary carcinoma cells in the G0/G1 phase of the cell cycle. Eur J Cancer Clin Oncol (1983) 1.49
The fragile X chromosome. Int Rev Cytol (1983) 1.49
Report of the committee on cytogenetic markers. Cytogenet Cell Genet (1989) 1.48
Colour Doppler velocity imaging of the myocardium. Ultrasound Med Biol (1992) 1.48
The value of Doppler color flow mapping in determining pulmonary blood supply in infants with pulmonary atresia with ventricular septal defect. J Am Coll Cardiol (1989) 1.47
Ventilation and acid-base changes in deep coma due to barbiturate or tricyclic antidepressant poisoning. Clin Toxicol (1977) 1.47
Hippocampal neurons are damaged by caffeine-augmented electroshock seizures. Biol Psychiatry (1996) 1.46
The prognostic and predictive value of serum CA19.9 in pancreatic cancer. Ann Oncol (2012) 1.46
Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J Neurosci (1999) 1.45
Assessing diagnosis in heart failure: which features are any use? QJM (1997) 1.45