Published in Prog Mol Subcell Biol on January 01, 1999
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol Cell Biol (2000) 1.83
Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators. J Cell Biol (2000) 1.36
Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J Cell Biol (2001) 1.26
Rho GTPases. Integrating integrin signaling. J Cell Biol (2000) 1.07
p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch Pharmacol (2004) 1.03
Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor. Biochem J (2000) 0.99
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. Biochem J (2002) 0.94
The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain. PLoS One (2010) 0.87
Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays (2013) 0.79
Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol (1999) 6.01
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol (1998) 4.91
A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature (1995) 4.59
Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science (1997) 3.89
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell (1994) 3.57
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J Cell Biol (1997) 3.28
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J (2001) 2.50
Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation. J Cell Biol (1997) 2.42
Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol (2000) 2.38
Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res (2000) 2.26
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO J (1998) 1.92
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nat Cell Biol (1999) 1.87
Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain. J Biol Chem (1997) 1.86
Rho family proteins in cell adhesion and cell migration. Eur J Cancer (2000) 1.68
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64
Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells. Oncogene (1995) 1.59
Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. J Biol Chem (1999) 1.39
Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Semin Cancer Biol (2001) 1.30
Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene (1995) 1.23
Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer (2006) 1.20
Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C. J Biol Chem (1997) 1.18
Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression. J Biol Chem (2001) 1.18
Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth. Mol Cell Neurosci (1997) 1.15
Regulation of p21rac activation in human neutrophils. Blood (1999) 1.09
Expression of Rho GTPases using retroviral vectors. Methods Enzymol (2000) 1.08
Invasiveness of T-cell hybridomas in vitro and their metastatic potential in vivo. Cancer Res (1985) 1.02
Construction and analysis of an EMBL-3 phage library containing partially digested human chromosome 21-specific DNA inserts (15-20 kb). Cytometry (1986) 0.97
Rho-like GTPases: their role in epithelial cell-cell adhesion and invasion. Eur J Cancer (1999) 0.96
Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice. J Cancer Res Clin Oncol (2008) 0.94
Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer (1985) 0.94
Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas. Cancer Res (1986) 0.93
Rho-like GTPases in tumor cell invasion. Methods Enzymol (2000) 0.93
Rho-like GTPases: their role in epithelial cell-cell adhesion and invasion. Eur J Cancer (1999) 0.91
Surface morphology and agglutinability with concanavalin A in normal and transformed murine fibroblasts. J Cell Biol (1976) 0.89
Rho-like GTPases: their role in cell adhesion and invasion. Biochem Soc Symp (1999) 0.88
Differences in density of Concanavalin A-binding sites due to differences in surface morphology of suspended normal and transformed 3T3 fibroblasts. J Cell Sci (1975) 0.87
Increase in fluidity of membrane lipids in lymphocytes, fibroblasts and liver cells stimulated for growth. FEBS Lett (1977) 0.87
Effect of proteolytic inhibitors on growth and surface architecture of normal and transformed cells. Exp Cell Res (1974) 0.87
Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements. Cytogenet Cell Genet (1986) 0.86
Separation and analysis of human chromosomes by combined velocity sedimentation and flow sorting applying single- and dual-laser flow cytometry. Cytometry (1984) 0.85
Localization of the lipid probe 1,6-diphenyl-1,3,5 hexatriene (DPH) in intact cells by fluorescence microscopy. Exp Cell Res (1978) 0.84
Oncogene activation in human myeloid leukemia. Cancer Res (1985) 0.84
Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice. Cancer Res (1988) 0.82
Effect of cancer-related and drug-induced alterations in surface carbohydrates on the invasive capacity of mouse and rat cells. Cancer Res (1986) 0.82
Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine. Clin Exp Metastasis (1990) 0.81
Translocation of a fluorescent lipid probe between contacting cells: evidence for membrane lipid interactions. FEBS Lett (1978) 0.80
Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells. Biochem Pharmacol (2001) 0.79
A comparative study of four cytochemical detection methods of concanavalin A binding sites on the cell membrane. Exp Cell Res (1975) 0.79
Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma. Cancer Genet Cytogenet (1985) 0.78
Capping of surface immunoglobulin on 'hairy cells' is independent of energy production. J Cell Sci (1979) 0.78
The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16. Cytogenet Cell Genet (1995) 0.77
Sublocalization of an invasion-inducing locus and other genes on human chromosome 7. Cytogenet Cell Genet (1992) 0.77
Decrease in 5'-nucleotidase activity in malignant transformed and normal stimulated cells. Cancer Res (1978) 0.77
Studies on the inhibition of protein synthesis by selenodiglutathione. Biochem J (1979) 0.77
Efforts to produce human cytotoxic T-cell hybridomas by electrofusion and PEG fusion. Hybridoma (1987) 0.77
Expression of Ly-6.2 and Thy-1 antigens on NIH 3T3 cells suppressed after transformation with activated human ras-oncogenes. Int J Cancer (1986) 0.76
Binding and cytochemical detection of cell-bound concanavalin A. Exp Cell Res (1974) 0.76
Invasive and metastatic potential induced by ras-transfection into mouse BW5147 T-lymphoma cells. Cancer Res (1987) 0.76
Separation of large quantities of chromosomes by velocity sedimentation at unit gravity. Exp Cell Res (1980) 0.75
Localization of genes on fractionated rat chromosomes by molecular hybridization. Exp Cell Res (1982) 0.75
Cell surface microvilli and cell agglutinability. Cell Biol Int Rep (1977) 0.75
Gene mapping by chromosome spot hybridization. Cytometry (1985) 0.75
Separation of large quantities of Chinese hamster chromosomes by velocity sedimentation at unit gravity followed by blow sorting (FACS II). Exp Cell Res (1980) 0.75
Separation of human metaphase chromosomes at neutral pH by velocity sedimentation at 20 times gravity. Exp Cell Res (1981) 0.75
Contact-mediated changes in cytoagglutination. Exp Cell Res (1975) 0.75
Separation of cells and cell organelles by weak physical forces IV. Applications. Prog Clin Biol Res (1982) 0.75
Cell cycle dependent agglutinability, distribution of concanavalin A binding sites and surface morphology of normal and transformed fibroblasts. Adv Exp Med Biol (1975) 0.75
Surface morphology and agglutination of lectin-treated human lymphocytes and lymphoblasts. J Cell Sci (1976) 0.75
A new unit gravity sedimentation chamber. Anal Biochem (1980) 0.75