Published in Drug Metab Dispos on April 01, 1999
Dose escalation of a curcuminoid formulation. BMC Complement Altern Med (2006) 3.59
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Retracted Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem Pharmacol (2010) 1.72
Fluorocurcumins as cyclooxygenase-2 inhibitor: molecular docking, pharmacokinetics and tissue distribution in mice. Pharm Res (2009) 1.48
Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res (2010) 1.32
Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation. Br J Cancer (2004) 1.27
Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model. AAPS PharmSciTech (2009) 1.19
Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest (2008) 1.18
Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem (2010) 1.18
Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res (Phila) (2011) 1.17
A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci (2010) 1.17
Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease. J Alzheimers Dis (2011) 1.14
Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol (2007) 1.13
Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A (2011) 1.08
Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol (2011) 1.08
Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury. J Neuroinflammation (2014) 1.04
Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin Med (2011) 1.03
Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem (2010) 1.02
4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. Neoplasia (2003) 1.00
Degradation of Curcumin: From Mechanism to Biological Implications. J Agric Food Chem (2015) 0.99
A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation. Lab Invest (2011) 0.98
Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol (2013) 0.97
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther (2012) 0.96
Colorectal cancer: chemopreventive role of curcumin and resveratrol. Nutr Cancer (2010) 0.96
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis (2009) 0.94
Highly stabilized curcumin nanoparticles tested in an in vitro blood-brain barrier model and in Alzheimer's disease Tg2576 mice. AAPS J (2012) 0.94
Highly loaded, sustained-release microparticles of curcumin for chemoprevention. J Pharm Sci (2011) 0.94
Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Mol Neurodegener (2012) 0.93
Tea polyphenols and their roles in cancer prevention and chemotherapy. Int J Mol Sci (2008) 0.91
Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages. J Clin Biochem Nutr (2008) 0.91
Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations. Genes Nutr (2011) 0.91
Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. J Mol Neurosci (2012) 0.90
Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents. Drug Des Devel Ther (2014) 0.90
Nanotechnology-applied curcumin for different diseases therapy. Biomed Res Int (2014) 0.90
Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles. Int J Nanomedicine (2012) 0.89
Molecular inclusion complex of curcumin-β-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel. AAPS PharmSciTech (2013) 0.88
A multi-targeted approach to suppress tumor-promoting inflammation. Semin Cancer Biol (2015) 0.87
Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats. PLoS One (2014) 0.87
Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993). Cancer Chemother Pharmacol (2014) 0.87
Preparation, characterization, in vivo pharmacokinetics, and biodistribution of polymeric micellar dimethoxycurcumin for tumor targeting. Int J Nanomedicine (2015) 0.86
The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J Biol Chem (2008) 0.86
Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells. PLoS One (2014) 0.86
Biphasic effect of curcumin on morphine tolerance: a preliminary evidence from cytokine/chemokine protein array analysis. Evid Based Complement Alternat Med (2011) 0.85
Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors. Int J Mol Med (2010) 0.85
Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice. Daru (2013) 0.84
Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications. BMC Biotechnol (2008) 0.83
Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.82
Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice. Biomed Res Int (2014) 0.82
A liquid chromatography-tandem mass spectrometric method for quantification of curcumin-O-glucuronide and curcumin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2012) 0.82
Targeted delivery of curcumin to tumors via PEG-derivatized FTS-based micellar system. AAPS J (2014) 0.82
Dibenzoylmethane exerts metabolic activity through regulation of AMP-activated protein kinase (AMPK)-mediated glucose uptake and adipogenesis pathways. PLoS One (2015) 0.81
Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools. J Labelled Comp Radiopharm (2013) 0.81
Neuroprotection and sensorimotor functional improvement by curcumin after intracerebral hemorrhage in mice. J Neurotrauma (2011) 0.81
Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett (2013) 0.81
Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. PLoS One (2014) 0.80
Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. Curr Pharm Des (2013) 0.80
In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration. Int J Nanomedicine (2012) 0.80
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS One (2013) 0.80
Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease. J Alzheimers Dis (2015) 0.80
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Mol Pain (2014) 0.79
Liver-Stage Specific Response among Endemic Populations: Diet and Immunity. Front Immunol (2015) 0.79
Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile duct cannulated rats. Mol Pharm (2013) 0.79
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges. Immun Ageing (2016) 0.79
Effects of tetrahydrocurcumin on hypoxia-inducible factor-1α and vascular endothelial growth factor expression in cervical cancer cell-induced angiogenesis in nude mice. Biomed Res Int (2015) 0.78
Beyond Yellow Curry: Assessing Commercial Curcumin Absorption Technologies. J Am Coll Nutr (2015) 0.78
Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. Inflammation (2015) 0.78
A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2014) 0.78
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression. Int J Clin Oncol (2013) 0.78
Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. J Vet Sci (2009) 0.78
Recent Advances of Curcumin and its Analogues in Breast Cancer Prevention and Treatment. RSC Adv (2015) 0.78
Bioavailability of a lipidic formulation of curcumin in healthy human volunteers. Pharmaceutics (2012) 0.77
Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites. Antioxidants (Basel) (2015) 0.77
Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein: a nanovehicle to transport curcumin, an antioxidant and anti-amyloid bioflavonoid. Biochim Biophys Acta (2010) 0.77
Natural Compounds as Therapeutic Agents in the Treatment Cystic Fibrosis. J Genet Syndr Gene Ther (2016) 0.77
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. J Control Release (2013) 0.77
Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s). Evid Based Complement Alternat Med (2015) 0.77
Synthesis of novel C5-curcuminoid-fatty acid conjugates and mechanistic investigation of their anticancer activity. Bioorg Med Chem Lett (2015) 0.77
Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS). AAPS PharmSciTech (2010) 0.77
Effects of Tetrahydrocurcumin on Tumor Growth and Cellular Signaling in Cervical Cancer Xenografts in Nude Mice. Biomed Res Int (2016) 0.77
A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators. Inflammation (2012) 0.77
Synergetic effect of SLN-curcumin and LDH-5-Fu on SMMC-7721 liver cancer cell line. Cancer Biother Radiopharm (2013) 0.77
Multi-layer polymeric implants for sustained release of chemopreventives. Cancer Lett (2012) 0.77
Wound healing: a new perspective on glucosylated tetrahydrocurcumin. Drug Des Devel Ther (2015) 0.77
Study of interaction of human serum albumin with curcumin by NMR and docking. J Mol Model (2014) 0.76
(1E,4E)-1,5-Bis(2,6-difluoro-phen-yl)penta-1,4-dien-3-one. Acta Crystallogr Sect E Struct Rep Online (2011) 0.76
Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle. J Cell Mol Med (2015) 0.76
Properties of lewis lung carcinoma cells surviving curcumin toxicity. J Cancer (2011) 0.76
The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice: brain uptake and metabolism after intravenous and subcutaneous injection. Alzheimers Res Ther (2013) 0.76
Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse. PLoS One (2013) 0.76
Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin. Sci Rep (2015) 0.76
Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration. Int J Nanomedicine (2016) 0.76
Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Semin Cancer Biol (2016) 0.76
Bladder cancer and urothelial impairment: the role of TRPV1 as potential drug target. Biomed Res Int (2014) 0.76
Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res (2015) 0.76
Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson's disease models. Int J Nanomedicine (2015) 0.76
Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin. Sci Rep (2016) 0.75
Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. Int J Oncol (2012) 0.75
Reversed-phase High-performance Liquid Chromatography Method for Analysis of Curcuminoids and Curcuminoid-loaded Liposome Formulation. Indian J Pharm Sci (2013) 0.75
Cardiovascular disease could be contained based on currently available data! Dose Response (2006) 0.75
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res (2001) 5.78
Increasing live donor kidney transplantation: a randomized controlled trial of a home-based educational intervention. Am J Transplant (2006) 3.11
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Preoperative carcinoembryonic antigen level as an independent prognostic factor in colorectal cancer: Taiwan experience. Jpn J Clin Oncol (2000) 1.74
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Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer (1999) 1.68
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Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis (1999) 1.67
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Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem (1999) 1.34
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Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol (2000) 1.20
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Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. Carcinogenesis (1999) 1.02
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Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene (1996) 0.91
Colonoscopy in abdominal actinomycosis. Gastrointest Endosc (2000) 0.90
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The changing pattern of intestinal tuberculosis: 30 years' experience. Int J Tuberc Lung Dis (1998) 0.86
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Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins. Mol Carcinog (1998) 0.85
Inhibition of TPA-induced protein kinase C and transcription activator protein-1 binding activities by theaflavin-3,3'-digallate from black tea in NIH3T3 cells. J Agric Food Chem (1999) 0.85
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Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin. Eur J Cancer (1996) 0.85
Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation. Free Radic Biol Med (1996) 0.85
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Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines. Toxicol Appl Pharmacol (2000) 0.81
Proliferation arrest and induction of CDK inhibitors p21 and p27 by depleting the calcium store in cultured C6 glioma cells. Eur J Cell Biol (1999) 0.81
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