Published in Methods Enzymol on January 01, 1976
Control of programmed cyclin destruction in a cell-free system. J Cell Biol (1989) 2.08
Escherichia coli contains a soluble ATP-dependent protease (Ti) distinct from protease La. Proc Natl Acad Sci U S A (1987) 1.87
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism. Am J Pathol (2005) 1.50
Biosynthesis and maturation of lactase-phlorizin hydrolase in the human small intestinal epithelial cells. Biochem J (1987) 1.39
Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins. Proc Natl Acad Sci U S A (1982) 1.36
Stabilization of nitrate reductase in maize roots by chymostatin. Plant Physiol (1990) 1.36
The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism. Biochem J (1986) 1.22
Enzymatic dissection of embryonic cell adhesive mechanisms. J Cell Biol (1980) 1.17
Multiple forms of tubulin in the cilia and cytoplasm of Tetrahymena thermophila. Proc Natl Acad Sci U S A (1985) 1.04
Enthalpy array analysis of enzymatic and binding reactions. Anal Biochem (2008) 1.03
Covalent crosslinking of angiotensin II to its binding sites in rat adrenal membranes. Proc Natl Acad Sci U S A (1982) 0.99
Synthesis of several membrane proteins during developmental aggregation in Myxococcus xanthus. J Bacteriol (1982) 0.97
Inhibition of carcinogen-induced chromosomal aberrations by an anticarcinogenic protease inhibitor. Proc Natl Acad Sci U S A (1980) 0.97
Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils. J Immunol (2009) 0.97
Effect of inhibitors of trypsin-like proteolytic enzymes Bacillus cereus T spore germination. J Bacteriol (1983) 0.96
Role of the degradation process in the mitogenic effect of epidermal growth factor. Proc Natl Acad Sci U S A (1980) 0.96
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation. J Biol Chem (2012) 0.95
Conditions for inhibiting and enhancing effects of the protease inhibitor antipain on x-ray-induced neoplastic transformation in hamster and mouse cells. Proc Natl Acad Sci U S A (1979) 0.95
Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J (1980) 0.93
A chymotrypsin-like proteinase that may be involved in desquamation in plantar stratum corneum. Arch Dermatol Res (1991) 0.91
Cell-free translation and thyroxine induction of carbamyl phosphate synthetase I messenger RNA in tadpole liver. Proc Natl Acad Sci U S A (1979) 0.89
Some effects of the administration of endotoxin in mice. Specific cleavage of serum albumin by an acid protease and the generation of amyloid serum component. J Clin Invest (1979) 0.87
Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A (1980) 0.85
A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors. Proc Natl Acad Sci U S A (1987) 0.85
A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases. Proc Natl Acad Sci U S A (1984) 0.85
Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity. Biochem J (1983) 0.84
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2. PLoS Pathog (2014) 0.84
Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus. Proc Natl Acad Sci U S A (1979) 0.84
Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells. J Virol (2011) 0.83
Biosynthesis of intestinal microvillar proteins. Processing of N-linked carbohydrate is not required for surface expression. Biochem J (1986) 0.83
A unique elastase in human blood platelets. J Clin Invest (1985) 0.83
Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate synthetase I in tadpole liver. Proc Natl Acad Sci U S A (1978) 0.82
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64. Clin Exp Metastasis (1997) 0.82
Construction, expression and characterization of chimaeric toxins containing the ribonucleolytic toxin restrictocin: intracellular mechanism of action. Biochem J (1997) 0.82
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell (2016) 0.80
A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor. Proc Natl Acad Sci U S A (1992) 0.80
The Xanthomonas campestris type III effector XopJ proteolytically degrades proteasome subunit RPT6. Plant Physiol (2015) 0.80
Biochemical aspects of a serine protease from Caesalpinia echinata Lam. (Brazilwood) seeds: a potential tool to access the mobilization of seed storage proteins. ScientificWorldJournal (2012) 0.79
Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17. Sci Rep (2016) 0.78
Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem (2011) 0.78
Separation, purification and N-terminal sequence analysis of a novel leupeptin-sensitive serine endopeptidase present in chemically induced rat mammary tumour. Biochem J (1992) 0.78
Characterization of the enzyme activity of human plasma lipoprotein (a) using synthetic peptide substrates. Biochem J (1991) 0.77
Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein. J Biol Chem (2008) 0.75
Metabolic cooperation following fusion of starfish ootid and primary oocyte restores meiotic-phase-promoting activity. Proc Natl Acad Sci U S A (1986) 0.75
Prevention of acute gastric erosions in the rat by novel semi-synthetic amphipathic analogues of pepstatin. Gut (1988) 0.75
Transmission of electrical signals by spin-wave interconversion in a magnetic insulator. Nature (2010) 4.10
New antibiotics, bleomycin A and B. J Antibiot (Tokyo) (1966) 3.58
Formation and reversion of Streptomycete protoplasts: cultural condition and morphological study. J Gen Microbiol (1974) 3.56
Spin Seebeck insulator. Nat Mater (2010) 3.01
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. J Antibiot (Tokyo) (1967) 2.60
3',4'-dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa. J Antibiot (Tokyo) (1971) 2.60
Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor. Science (1967) 2.55
Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) (1970) 2.52
Inhibition of DNA-dependent RNA synthesis by rifamycins. J Antibiot (Tokyo) (1968) 2.41
Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor. J Antibiot (Tokyo) (1968) 2.19
Letter: Two beta-lactamase inhibitors produced by a streptomyces. J Antibiot (Tokyo) (1973) 2.16
Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol (1986) 1.87
Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor. J Antibiot (Tokyo) (1968) 1.85
Inhibition of DNA-dependent RNA polymerase reaction of Escherichia coli by an antimicrobial antibiotic, streptovaricin. Biochim Biophys Acta (1968) 1.81
On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo. J Antibiot (Tokyo) (1969) 1.80
Effect of pepstatin on acid proteases. J Antibiot (Tokyo) (1971) 1.75
Studies on inactivation of kanamycin and resistances of E. coli. J Antibiot (Tokyo) (1967) 1.67
Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor. J Antibiot (Tokyo) (1968) 1.66
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot (Tokyo) (1976) 1.66
R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase. Antimicrob Agents Chemother (1975) 1.61
Phosphorylation and inactivation of aminoglycosidic antibiotics by E. coli carrying R factor. J Antibiot (Tokyo) (1968) 1.58
Letter: A thermolysin inhibitor produced by Actinomycetes: phospholamidon. J Antibiot (Tokyo) (1973) 1.50
Low-molecular-weight enzyme inhibitors of microbial origin. Annu Rev Microbiol (1982) 1.50
Bleomycin and other antitumor antibiotics of high molecular weight. Antimicrob Agents Chemother (Bethesda) (1965) 1.49
Studies on bleomycin. Cancer (1967) 1.49
Letter: Kanamycin phosphotransferase. I. Mechanism of cross resistance between kanamycin and lividomycin. J Antibiot (Tokyo) (1973) 1.44
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa. Appl Microbiol (1968) 1.43
Phosphorylation and inactivation of kanamycin by Pseudomonas aeruginosa. J Antibiot (Tokyo) (1968) 1.38
Chemistry and mechanism of action of bleomycin. Fed Proc (1974) 1.38
Activity and toxicity of bleomycin. J Antibiot (Tokyo) (1967) 1.35
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus. Appl Microbiol (1968) 1.35
Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes. Cancer Res (1972) 1.34
Inhibition of initiation of DNA-dependent RNA synthesis by an antibiotic B44p. Biochem Biophys Res Commun (1968) 1.28
Letter: Syntheses of 1-n-(S)-4-amino-2-hydroxybutyryl)-kanamycin B and -3', 4'-dideoxykanamycin B active against kanamycin-resistant bacteria. J Antibiot (Tokyo) (1973) 1.28
Effect of bleomycin on mammalian cell survival. J Natl Cancer Inst (1972) 1.24
Letter: Gentamicin acetyltransferase in Escherichia coli carrying R factor. J Antibiot (Tokyo) (1973) 1.23
Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo) (1972) 1.21
Effect of protease inhibitors of actinomycetes on lysosomal peptide-hydrolases from swine liver. J Antibiot (Tokyo) (1971) 1.19
Aminoglycoside 3'-phosphotransferase III, a new phosphotransferase. Resistance mechanism. J Antibiot (Tokyo) (1975) 1.19
Biological studies on bleomycin A. J Antibiot (Tokyo) (1967) 1.18
[Preferential inhibition of the growth of Escherichia coli strains carrying episomes]. J Antibiot (Tokyo) (1970) 1.17
Structures of new antibiotics napyradiomycins. J Antibiot (Tokyo) (1986) 1.16
Biosynthesis of napyradiomycins. J Antibiot (Tokyo) (1987) 1.16
The structure of pepstatin. J Antibiot (Tokyo) (1970) 1.15
Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase. Jpn J Cancer Res (1985) 1.15
6'-N-acetylation of 3',4'-dideoxykanamycin B by an enzyme in a resistant strain of Pseudomonas aeruginosa. J Antibiot (Tokyo) (1972) 1.13
Studies on formycin and formycin B in cells of Ehrlich carcinoma and E. coli. J Antibiot (Tokyo) (1967) 1.12
Aminoglycoside 3'-phosphotransferases I and II in Pseudomonas aeruginosa. J Antibiot (Tokyo) (1975) 1.11
Structure determinations of enzymatically phosphorylated products of aminoglycosidic antibiotics by proton magnetic resonance. J Antibiot (Tokyo) (1971) 1.10
A plasmid involved in chloramphenicol production in Streptomyces venezuelae: evidence from genetic mapping. J Gen Microbiol (1975) 1.10
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes. J Antibiot (Tokyo) (1970) 1.10
Mode of inhibition of coformycin on adenosine deaminase. J Antibiot (Tokyo) (1967) 1.10
Modes of action of phleomycin, bleomycin and formycin on HeLa S3 cells in synchronized culture. J Antibiot (Tokyo) (1967) 1.07
An evaluation of taxonomic criteria in streptomycetes on the basis of deoxyribonucleic acid homology. J Gen Microbiol (1972) 1.06
Possible control of formation of aerial mycelium and antibiotic production in Streptomyces by episomic factors. J Antibiot (Tokyo) (1970) 1.06
Prolongation of rat heart allograft survival by 15-deoxyspergualin. J Antibiot (Tokyo) (1987) 1.05
Isolation and characterization of lividomycin A inactivated by Pseudomonas aeruginosa and Escherichia coli carrying R factor. J Antibiot (Tokyo) (1972) 1.05
Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. J Antibiot (Tokyo) (1985) 1.04
A new antitumor antibiotic, spergualin: isolation and antitumor activity. J Antibiot (Tokyo) (1981) 1.04
Pyruvate kinase of Escherichia coli. Its role in supplying nucleoside triphosphates in cells under anaerobic conditions. J Biochem (1974) 1.03
Bottromycin A1, A2 and their structures. J Antibiot (Tokyo) (1966) 1.03
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. J Antibiot (Tokyo) (1978) 1.03
Biosynthetic studies of terpentecin. J Antibiot (Tokyo) (1986) 1.03
Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney. Biochim Biophys Acta (1980) 1.02
Biological studies on individual bleomycins. J Antibiot (Tokyo) (1968) 1.02
A -lactamase of Escherichia coli. Biochim Biophys Acta (1972) 1.02
Breaks and rejoining of DNA in cultured mammalian cells treated with bleomycin. Gan (1970) 1.02
Studies on the mechanism of antitumor effect of bleomycin of squamous cell carcinoma. J Antibiot (Tokyo) (1972) 1.01
Purification of bleomycins. J Antibiot (Tokyo) (1966) 1.01
Studies on marine microorganisms. V. A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud. J Antibiot (Tokyo) (1976) 1.01
An enzyme inhibitor, panosialin, produced by Streptomyces. II. Chemistry of panosialin, 5-alkylbenzene-1,3-disulfates. J Antibiot (Tokyo) (1971) 1.00
The distribution of 3H-bleomycin in mouse tissue. J Antibiot (Tokyo) (1968) 0.99
Protease inhibitors produced by microorganisms. Acta Biol Med Ger (1977) 0.99
Chemistry of bleomycin. XXI. Metal-complex of bleomycin and its implication for the mechanism of bleomycin action. J Antibiot (Tokyo) (1978) 0.98
Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. I. Taxonomy, production, isolation and preliminary characterization. J Antibiot (Tokyo) (1986) 0.98
The combined effects of bleomycin and sulfhydryl compounds on the thermal denaturation of DNA. Biochim Biophys Acta (1969) 0.98
Isolation and properties of valanimycin, a new azoxy antibiotic. J Antibiot (Tokyo) (1986) 0.98
Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties. J Antibiot (Tokyo) (1979) 0.98
Structure of an antitumor antibiotic, spergualin. J Antibiot (Tokyo) (1981) 0.97
Chemistry of bleomycin. XX. The X-ray structure determination of P-3A Cu(II)-complex a biosynthetic intermediate of bleomycin. J Antibiot (Tokyo) (1978) 0.97
Suppression of tissue graft rejection by spergualin. J Antibiot (Tokyo) (1985) 0.97
Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity. J Antibiot (Tokyo) (1986) 0.97
Macarbomycin, an inhibitor of peptidoglycan synthesis. J Antibiot (Tokyo) (1972) 0.97
Brain and physics of many-body problems. Kybernetik (1967) 0.97
Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. II. Structure of fatty acid residue and amino acid sequence. J Antibiot (Tokyo) (1986) 0.96
Studies on inhibitory effect of phosphoramidon and its analogs on thermolysin. Arch Biochem Biophys (1975) 0.96
Factors affecting infection of protoplasts with deoxyribonucleic acid of actinophage PK-66. J Virol (1968) 0.96
Studies on bleomycin: chemistry and the biological action. Biomedicine (1973) 0.96
Inhibition of RNA and DNA polymerase reactions by pluramycin A. Biochem Biophys Res Commun (1965) 0.96
Structure of antipain, a new Sakaguchi-positive product of streptomyces. J Antibiot (Tokyo) (1972) 0.95
New antibiotic napyradiomycins A2 and B4 and stereochemistry of napyradiomycins. J Antibiot (Tokyo) (1987) 0.95
The structural studies of formycin and formycin B. Tetrahedron Lett (1966) 0.94
Tetrahydropyranyl derivatives of daunomycin and adriamycin. J Antibiot (Tokyo) (1979) 0.94
Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. III. Structural elucidation of plipastatins. J Antibiot (Tokyo) (1986) 0.94
Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes. J Antibiot (Tokyo) (1973) 0.94
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. J Antibiot (Tokyo) (1984) 0.94
Immunological studies of aminoglycoside 3'-phosphotransferases. J Antibiot (Tokyo) (1976) 0.94
Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer. Arch Biochem Biophys (1976) 0.94
The structure of bestatin. J Antibiot (Tokyo) (1976) 0.94
Bacillus cereus beta-lactamase. Reaction with N-bromosuccinimide and the properties of the product. Biochim Biophys Acta (1975) 0.94