T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 1188995)

Published in J Psychiatry Neurosci on March 01, 1999

Authors

R Joober1, C Benkelfat, K Brisebois, A Toulouse, G Turecki, S Lal, D Bloom, A Labelle, P Lalonde, D Fortin, M Alda, R Palmour, G A Rouleau

Author Affiliations

1: Montreal General Hospital Research Institute, Douglas Hospital Research Centre, Verdun QC. rjoobe@po-box.mcgill.ca

Articles citing this

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet (2009) 1.38

Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Expert Opin Drug Metab Toxicol (2011) 1.31

G protein-coupled receptors in major psychiatric disorders. Biochim Biophys Acta (2006) 1.12

Pharmacogenomics: marshalling the human genome to individualise drug therapy. Gut (2003) 0.98

The promise and reality of pharmacogenetics in psychiatry. Psychiatr Clin North Am (2010) 0.92

Genome-wide association study of treatment refractory schizophrenia in Han Chinese. PLoS One (2012) 0.90

Understanding putative risk factors for schizophrenia: retrospective and prospective studies. J Psychiatry Neurosci (2005) 0.88

Differential effects of 5-HT(2A) and 5-HT(2C) receptor blockade on strategy-switching. Behav Brain Res (2011) 0.87

Genetic variations in human G protein-coupled receptors: implications for drug therapy. AAPS PharmSci (2001) 0.86

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms. Br J Clin Pharmacol (2014) 0.82

Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach. BMC Psychiatry (2007) 0.81

Genetics of schizophrenia: from animal models to clinical studies. J Psychiatry Neurosci (2002) 0.81

Pharmacogenetic research: a revolutionary science. J Psychiatry Neurosci (1999) 0.80

Negative predictors of clinical response to triptans in patients with migraine. Neurol Sci (2011) 0.78

Association of a Serotonin Receptor 2A Gene Polymorphism with Visual Sustained Attention in Early-Onset Schizophrenia Patients and their Non-Psychotic Siblings. Aging Dis (2012) 0.78

Predictive index for the onset of medication overuse headache in migraine patients. Neurol Sci (2013) 0.78

Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review. BMC Psychiatry (2017) 0.75

Articles cited by this

The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry (1976) 15.48

Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry (1994) 11.85

National Institute of Mental Health longitudinal study of chronic schizophrenia. Prognosis and predictors of outcome. Arch Gen Psychiatry (1991) 3.53

Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet (1995) 3.08

Anchoring the BPRS: an aid to improved reliability. Psychopharmacol Bull (1988) 1.88

Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group. Lancet (1996) 1.64

The genetics of Alzheimer disease: current status and future prospects. Arch Neurol (1998) 1.28

Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. Am J Psychiatry (1995) 1.17

An MspI polymorphism in the hyman serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum Mol Genet (1993) 1.13

Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res (1998) 1.05

Dissecting the genetic complexity of schizophrenia. Mol Psychiatry (1997) 1.04

A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry (1998) 1.04

Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction. Br J Psychiatry (1985) 1.01

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine. Mol Psychiatry (1998) 1.00

Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer Dis Assoc Disord (1998) 0.99

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients. Neuropsychopharmacology (1998) 0.99

Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. Am J Psychiatry (1989) 0.98

Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia. Lancet (1997) 0.97

Defining treatment refractoriness in schizophrenia. Schizophr Bull (1990) 0.96

A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. J Neurochem (1997) 0.93

Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine. Am J Psychiatry (1996) 0.92

Molecular genetics of hereditary dystonia--mutations in the GTP cyclohydrolase I gene. Brain Res Bull (1997) 0.88

Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet (1996) 0.87

Gender differences in neuroleptic nonresponsive clozapine-treated schizophrenics. Biol Psychiatry (1996) 0.85

Effect of a haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients. Am J Psychiatry (1998) 0.85

Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases. Am J Hum Genet (1989) 0.85

Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biol Psychiatry (1991) 0.82

Heterogeneity of schizophrenia: relationship to latency of neuroleptic response. Psychiatry Res (1991) 0.82

Genetic variation of 5-HT2A receptor and response to clozapine. Lancet (1995) 0.81

5HT 2a receptor T102C polymorphism and schizophrenia. Lancet (1996) 0.80

5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected. Psychiatr Genet (1996) 0.80

Symptomatology and electrodermal activity as predictors of neuroleptic response in young male schizophrenic inpatients. Psychiatry Res (1992) 0.77

Monitoring plasma levels of fluphenazine during chronic therapy with fluphenazine decanoate. J Clin Pharm Ther (1995) 0.77

The evolution of treatment resistance: biologic implications. J Clin Psychopharmacol (1998) 0.77

Articles by these authors

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (2009) 13.45

The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron (2001) 4.97

Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction. Br Med J (1972) 4.26

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Nat Genet (1996) 4.16

Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nat Genet (1998) 3.62

Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. Cell (1987) 3.60

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet (2001) 3.59

LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry (2007) 3.49

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature (1988) 3.27

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci (1998) 3.24

A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. J Clin Psychopharmacol (1993) 2.92

Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. The Canadian Collaborative Group for research in schizophrenia. Arch Gen Psychiatry (2000) 2.66

Outpatient termination of pregnancy. Br Med J (1971) 2.60

Determinants of skeletal muscle catabolism after severe burn. Ann Surg (2000) 2.56

Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry (2005) 2.54

Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet (1998) 2.51

Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A (1997) 2.50

Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry (1999) 2.45

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J Neurosci (2001) 2.43

Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature (1987) 2.32

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol (2003) 2.32

Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology (2000) 2.28

Clinical assessment of urethral sphincter function. J Urol (1993) 2.17

Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer (2000) 2.10

Chikungunya fever: a re-emerging viral infection. Indian J Med Microbiol (2008) 2.06

Safety and immunogenicity of the intradermal Thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine. Indian J Med Microbiol (2005) 2.04

Replacement of chlorpromazine with other neuroleptics: effect on abnormal skin pigmentation and ocular changes. J Psychiatry Neurosci (1993) 2.02

Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis. J Med Genet (2008) 2.00

Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review. Acta Psychiatr Scand (2006) 1.99

Cardiovascular and respiratory effects of morphine and pentazocine in patients with myocardial infarction. Lancet (1969) 1.95

Mutations in FUS cause FALS and SALS in French and French Canadian populations. Neurology (2009) 1.87

Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder. Chromosoma (1974) 1.82

Prolactin, phenothiazines, admission to mental hospital, and carcinoma of the breast. Lancet (1973) 1.80

High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH. Hum Mol Genet (2001) 1.79

Polyglutamine-containing proteins in schizophrenia. Mol Psychiatry (1999) 1.77

Psychosocial consequences of therapeutic abortion King's termination study III. Br J Psychiatry (1976) 1.76

Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain. J Thromb Haemost (2006) 1.75

Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy. Neurology (2000) 1.73

Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease. Am J Hum Genet (1996) 1.70

Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA. Hum Mol Genet (2000) 1.70

Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Mol Psychiatry (2010) 1.69

Automated detection of diabetic retinopathy on digital fundus images. Diabet Med (2002) 1.69

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology (2009) 1.67

Detection and characterization of viral genomes and search for tumoral antigens in two hamster cell lines derived from tumors induced by bovine papillomavirus type 1. Int J Cancer (1981) 1.66

Epidemiological and clinical features in 165 cases of granuloma inguinale. Br J Vener Dis (1970) 1.65

Efficacy of co-trimoxazole in Donovanosis. A preliminary report. Br J Vener Dis (1978) 1.62

Community studies on prevalence of HBsAg in two urban populations of southern India. Indian Pediatr (2000) 1.62

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide. Psychol Med (2007) 1.59

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry (2003) 1.58

Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis. Eur J Hum Genet (2002) 1.56

Compound heterozygous D90A and D96N SOD1 mutations in a recessive amyotrophic lateral sclerosis family. Ann Neurol (2001) 1.55

Dopaminergic neurotransmission and restless legs syndrome: a genetic association analysis. Neurology (2001) 1.54

Effect on mood of subthalamic DBS for Parkinson's disease: a consecutive series of 24 patients. Neurology (2002) 1.53

Protective effect of pregnancy in women with lithium-responsive bipolar disorder. J Affect Disord (2000) 1.51

Nedocromil sodium: a new drug for the management of bronchial asthma. Thorax (1984) 1.51

Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. Neurology (1996) 1.50

A strategy to detect beta-thalassaemia minor. Lancet (1977) 1.49

Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry (2007) 1.47

Intravenous salbutamol and cardiogenic shock. Lancet (1972) 1.46

Anticipation in familial cavernous angioma: ascertainment bias or genetic cause. Acta Neurol Scand (1998) 1.46

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry (2007) 1.45

Predicting high blood pressure in pregnancy: a multivariate approach. J Hypertens (1998) 1.45

The transmission of information in primary receptor neurones and second-order neurones of a phasic system. J Physiol (1962) 1.44

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum Mol Genet (1994) 1.42

Mutations in GJB6 cause hidrotic ectodermal dysplasia. Nat Genet (2000) 1.42

Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics (2001) 1.42

Genome-wide association study of Tourette's syndrome. Mol Psychiatry (2012) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Gene discovery using the maize genome database ZmDB. Nucleic Acids Res (2000) 1.41

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Transl Psychiatry (2011) 1.40

Lack of association between bipolar disorder and tyrosine hydroxylase: a meta-analysis. Am J Med Genet (1997) 1.40

Recent advances in the genetics of distal hereditary motor neuropathy give insight to a disease mechanism involving copper homeostasis that may extend to other motor neuron disorders. Clin Genet (2011) 1.39

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Clozapine: current status and role in the pharmacotherapy of schizophrenia. Can J Psychiatry (1996) 1.38

Hazard of yawning. CMAJ (1990) 1.38

Comparison of the conventional diagnostic modalities, bactec culture and polymerase chain reaction test for diagnosis of tuberculosis. Indian J Med Microbiol (2005) 1.37

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry (2003) 1.37

A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians. Am Heart J (2001) 1.37

Frequency of spinocerebellar ataxia type 1, dentatorubropallidoluysian atrophy, and Machado-Joseph disease mutations in a large group of spinocerebellar ataxia patients. Neurology (1996) 1.36

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry (1994) 1.34

The syndrome of congenital telangiectatic erythema and stunted growth. J Pediatr (1966) 1.34

Chromosomal breakage and acute leukemia in congenital telangiectatic erythema and stunted growth. Ann Intern Med (1966) 1.33