Published in Gastroenterology on May 01, 1999
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut (2002) 2.31
Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver. Gut (2000) 1.89
CpG island methylation in colorectal adenomas. Am J Pathol (2001) 1.88
The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. Am J Pathol (2001) 1.73
Concordant CpG island methylation in hyperplastic polyposis. Am J Pathol (2002) 1.56
Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest (2000) 1.44
Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PLoS One (2010) 1.25
Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma. World J Gastroenterol (2008) 1.06
p16INK4a hypermethylation and p53, p16 and MDM2 protein expression in esophageal squamous cell carcinoma. BMC Cancer (2010) 1.06
Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer. Am J Pathol (2000) 1.05
CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer (2003) 1.04
CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis. Clin Cancer Res (2012) 1.00
RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence. Cancer Res (2009) 1.00
Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol (2010) 0.98
The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer. Am J Pathol (2007) 0.94
Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity. J Cancer Res Clin Oncol (2010) 0.93
p16 gene methylation in colorectal cancers associated with Duke's staging. World J Gastroenterol (2001) 0.93
Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin. Mol Cell Biol (2002) 0.90
p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors. Cancer Biol Ther (2005) 0.89
Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression. Biomed Res Int (2012) 0.80
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther (2013) 0.80
Protein-bound polysaccharide-K reduces colitic tumors and improves survival of inflammatory bowel disease in vivo. Oncol Lett (2011) 0.76
The association between methylated CDKN2A and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis. Ther Clin Risk Manag (2016) 0.75
Promoter and histone methylation and p16(INK4A) gene expression in colon cancer. Exp Ther Med (2012) 0.75
A case of ovarian mucinous adenocarcinoma in a premenarcheal girl. Int J Clin Oncol (2011) 0.75
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science (1992) 24.32
Penicillin-binding proteins and cell shape in E. coli. Nature (1975) 10.20
A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A (1974) 8.74
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell (1984) 6.53
Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res (1993) 5.82
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet (2001) 4.97
Animal cell cycle. Annu Rev Biochem (1978) 4.80
DNA synthesis inhibition and the induction of protein X in Escherichia coli. J Mol Biol (1976) 4.65
Membrane transport proteins. Proteins that appear to be parts of membrane transport systems are being isolated and characterized. Science (1968) 4.23
Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics. J Biol Chem (1967) 4.01
Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells. Proc Natl Acad Sci U S A (1969) 3.98
Changes of membrane proteins and their relation to deoxyribonucleic acid synthesis and cell division of Escherichia coli. J Biol Chem (1970) 3.76
Multiple pathways of putrescine biosynthesis in Escherichia coli. J Biol Chem (1966) 3.74
Inhibition of an early event in the cell division cycle of Escherichia coli by FL1060, an amidinopenicillanic acid. J Bacteriol (1975) 3.49
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46
Model for regulation of Escherichia coli DNA repair functions. Proc Natl Acad Sci U S A (1975) 3.32
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res (1991) 3.24
Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med (1984) 3.22
Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res (1992) 3.12
Susceptibility testing of Cryptococcus neoformans: a microdilution technique. J Clin Microbiol (1992) 3.12
Multienzyme complex for metabolic channeling in mammalian DNA replication. Proc Natl Acad Sci U S A (1980) 3.12
Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips. J Biol Chem (1969) 3.05
A binding site for sulfate and its relation to sulfate transport into Salmonella typhimurium. J Biol Chem (1966) 3.04
Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer Inst (1997) 2.95
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (1986) 2.89
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88
Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci U S A (1993) 2.85
Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells. Cell (1979) 2.84
Purification and properties of a sulfate-binding protein from Salmonella typhimurium. J Biol Chem (1966) 2.69
Conditional mutations involving septum formation in Escherichia coli. J Bacteriol (1967) 2.64
Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut (1996) 2.58
Evidence for a relationship between deoxyribonucleic acid metabolism and septum formation in Escherichia coli. J Bacteriol (1968) 2.54
Inhaled corticosteroids, bone formation, and osteocalcin. Lancet (1991) 2.45
Thymidine and thymine incorporation into deoxyribonucleic acid: inhibition and repression by uridine of thymidine phosphorylase of Escherichia coli. J Bacteriol (1967) 2.41
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A (1994) 2.29
Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. Proc Natl Acad Sci U S A (1979) 2.28
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. Clin Cancer Res (1999) 2.19
Sequence of enzyme synthesis and gene replication during the cell cycle of Bacillus subtilis. Proc Natl Acad Sci U S A (1965) 2.18
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem (1995) 2.17
Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology (1996) 2.16
The use of Medpor coated tear drainage tube in conjunctivodacryocystorhinostomy. Eye (Lond) (2007) 2.13
Location of sulfate-binding protein in Salmonella typhimurium. J Bacteriol (1968) 2.11
Pretransplant IgG reactivity to apoptotic cells correlates with late kidney allograft loss. Am J Transplant (2014) 2.09
Regulation of sulfate transport in Salmonella typhimurium. J Bacteriol (1966) 2.06
A permeable animal cell preparation for studying macromolecular synthesis. DNA synthesis and the role of deoxyribonucleotides in S phase initiation. Biochemistry (1978) 2.05
Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science (1998) 1.97
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res (1996) 1.97
Changes in the synthesis of actin and other cell proteins after stimulation of serum-arrested cells. Proc Natl Acad Sci U S A (1979) 1.95
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci U S A (2000) 1.94
Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells. Proc Natl Acad Sci U S A (1982) 1.93
Evidence for a sulfate-binding site external to the cell membrane of Salmonella typhimurium. Biochim Biophys Acta (1965) 1.93
Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res (1997) 1.92
Genetics of sulfate transport by Salmonella typhimurium. J Bacteriol (1971) 1.92
Cell-free activity of a sulfate binding site involved in active transport. Proc Natl Acad Sci U S A (1966) 1.92
Deoxyribonucleic acid synthesis during the division cycle of Escherichia coli: a comparison of strains B-r, K-12, 15, and 15T- under conditions of slow growth. J Bacteriol (1974) 1.90
A biosynthetic ornithine decarboxylase in Escherichia coli. Biochem Biophys Res Commun (1965) 1.87
Control of thymidine kinase mRNA during the cell cycle. Mol Cell Biol (1987) 1.86
Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci U S A (1982) 1.86
Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci U S A (1998) 1.86
Differential display using one-base anchored oligo-dT primers. Nucleic Acids Res (1994) 1.85
Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans. J Biol Chem (1998) 1.84
Cyclin E, a potential prognostic marker for breast cancer. Cancer Res (1994) 1.82
Nosocomial pneumonia caused by carbapenem-resistant Raoultella planticola: a case report and literature review. Infection (2015) 1.82
Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res (2000) 1.80
Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells. Blood (1991) 1.80
Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell (1983) 1.76
Recent advances in differential display. Curr Opin Immunol (1995) 1.75
Cell division in Escherichia coli: evidence for regulation of septation by effector molecules. J Mol Biol (1972) 1.74
Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase. J Biol Chem (1971) 1.73
Energy requirement for degradation of tumor-associated protein p53. Mol Cell Biol (1984) 1.73
American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12. Gastroenterology (1998) 1.71
Accumulation of a protein required for division during the cell cycle of Escherichia coli. J Bacteriol (1970) 1.71
Are right- and left-sided colon neoplasms distinct tumors? Dig Dis (1997) 1.70
Enzyme synthesis in synchronous cultures of bacteria. Biochem Biophys Res Commun (1964) 1.68
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
Modulation of interactions of Candida albicans and endothelial cells by fluconazole and amphotericin B. Antimicrob Agents Chemother (1992) 1.67
Loss of epidermal growth factor requirement and malignant transformation. Proc Natl Acad Sci U S A (1979) 1.65
Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. NIAID AIDS Clinical Trials Group. J Acquir Immune Defic Syndr (1993) 1.64
Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells. J Cell Physiol (1984) 1.63
25-hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue. Lancet (2001) 1.61
Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites. Oncogene (2000) 1.58
Cyclin E and cyclin A as candidates for the restriction point protein. Cancer Res (1993) 1.57
Exploiting cancer cell cycling for selective protection of normal cells. Cancer Res (2001) 1.57
Adenosine 5'-diphosphate-glucose pyrophosphorylase from potato tuber. Significance of the N terminus of the small subunit for catalytic properties and heat stability. Plant Physiol (1995) 1.56
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment. Mol Med (2000) 1.56
A general method for permeabilizing monolayer and suspension cultured animal cells. Exp Cell Res (1979) 1.56
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ (2009) 1.55
Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol (1998) 1.52
Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains. J Virol (1998) 1.52
Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. The GUSTO-IIb Investigators. Circulation (1998) 1.52
Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein. J Biol Chem (2000) 1.50
TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. Genomics (1999) 1.49
Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators. Can J Cardiol (2000) 1.47
Measurement of neutrino oscillation with KamLAND: evidence of spectral distortion. Phys Rev Lett (2005) 1.46
Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth. Proc Natl Acad Sci U S A (1983) 1.46
p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res (1994) 1.46
Nuclear posttranscriptional processing of thymidine kinase mRNA at the onset of DNA synthesis. Proc Natl Acad Sci U S A (1988) 1.45