Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 10229623)

Published in J Med Chem on May 06, 1999

Authors

E J Jacobsen1, M A Mitchell, S K Hendges, K L Belonga, L L Skaletzky, L S Stelzer, T J Lindberg, E L Fritzen, H J Schostarez, T J O'Sullivan, L L Maggiora, C W Stuchly, A L Laborde, M F Kubicek, R A Poorman, J M Beck, H R Miller, G L Petzold, P S Scott, S E Truesdell, T L Wallace, J W Wilks, C Fisher, L V Goodman, P S Kaytes

Author Affiliations

1: Department of Structural, Analytical and Medicinal Chemistry, Michigan 49007, USA.

Articles by these authors

(truncated to the top 100)

Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med (1995) 6.71

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci U S A (1999) 4.52

Metabolism of dibenzothiophene by a Beijerinckia species. Appl Environ Microbiol (1977) 4.30

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor". Proc Natl Acad Sci U S A (1972) 4.03

Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology (1980) 4.02

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature (1990) 3.81

Oxidation of naphthalene by a multicomponent enzyme system from Pseudomonas sp. strain NCIB 9816. J Bacteriol (1982) 3.68

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res (1994) 3.65

Effects of teacher attention on attending behavior of two boys at adjacent desks. J Appl Behav Anal (1970) 3.59

Drip breast milk: it's composition, collection and pasteurization. Early Hum Dev (1977) 3.47

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab (1995) 3.34

Identification of specific binding proteins for a nuclear location sequence. Nature (1989) 3.11

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene (2006) 3.09

A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes. J Clin Invest (1990) 3.03

Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J Med Chem (1996) 2.82

Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat. Immunology (1971) 2.78

Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet (1995) 2.74

Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol (2000) 2.67

The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation. EMBO J (1990) 2.57

Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol (1992) 2.54

Natural history of stage IV epithelial ovarian cancer. J Clin Oncol (1999) 2.52

Production and activities of IgE in helminth infection. Prog Allergy (1982) 2.47

Imaging features of retroperitoneal and pelvic schwannomas. Clin Radiol (2005) 2.32

Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital. BJU Int (2003) 2.29

A breakdown of symmetry in the folding transition state of protein L. J Mol Biol (2000) 2.26

Modified staging system for extremity soft tissue sarcomas. Ann Surg Oncol (1999) 2.16

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J (1995) 2.14

Human intestinal mucosal mast cells: evaluation of fixation and staining techniques. J Clin Pathol (1981) 2.11

Management of metastatic melanoma during pregnancy. BMJ (1998) 2.10

Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat Med (1999) 2.07

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene (1994) 2.05

Generation of mucosal mast cells is stimulated in vitro by factors derived from T cells of helminth-infected rats. Nature (1982) 2.02

Pharmacological regulation of calmodulin. Ann N Y Acad Sci (1980) 2.02

Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J Exp Med (2000) 1.98

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol (1988) 1.94

The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype. J Exp Med (1991) 1.89

Immune reactions in mucous membranes. IV. Histochemistry of intestinal mast cells during helminth expulsion in the rat. Am J Pathol (1972) 1.86

Curcumin is an in vivo inhibitor of angiogenesis. Mol Med (1998) 1.81

Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet (1992) 1.81

Protection against Nippostrongylus brasiliensis by adoptive immunization with immune thoracic duct lymphocytes. Cell Immunol (1978) 1.80

Natural history and prognosis of untreated stage I epithelial ovarian carcinoma. J Clin Oncol (1996) 1.78

Reduction of nonspecific fluorescence in respiratory specimens by pretreatment with N-acetylcysteine. J Clin Microbiol (1986) 1.77

Adoptive transfer of the intestinal mast cell response in rats infected with Nippostrongylus brasiliensis. Cell Immunol (1979) 1.77

Diffusion-weighted magnetic resonance imaging: a potential non-invasive marker of tumour aggressiveness in localized prostate cancer. Clin Radiol (2008) 1.76

Surgical management of primary and recurrent retroperitoneal liposarcoma. Br J Surg (2005) 1.71

Aggressive angiomyxoma. A report of four cases occurring in men. Am J Surg Pathol (1992) 1.69

A genetic association for cigarette smoking behavior. Health Psychol (1999) 1.69

Breast diseases: color Doppler US in differential diagnosis. Radiology (1993) 1.67

Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer (1993) 1.67

Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells. J Invest Dermatol (1993) 1.66

Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital. Ann Oncol (2005) 1.66

Detection of point mutations in N-ras and K-ras genes of human embryonal rhabdomyosarcomas using oligonucleotide probes and the polymerase chain reaction. Cancer Res (1989) 1.64

Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs. Proc Natl Acad Sci U S A (1974) 1.63

Identification and characterization of dppA, an Escherichia coli gene encoding a periplasmic dipeptide transport protein. J Bacteriol (1991) 1.63

Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rat. Nature (1985) 1.63

Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype. Br J Cancer (2008) 1.62

Specific inhibition of endothelial cell proliferation by thrombospondin. Biochem Biophys Res Commun (1990) 1.62

Systemic release of mucosal mast-cell protease in primed rats challenged with Nippostrongylus brasiliensis. Immunology (1983) 1.61

Inhibition of lung surfactant protein B expression during Pneumocystis carinii pneumonia in mice. J Lab Clin Med (1999) 1.58

Quantitative analysis of mucosal mast cell protease in the intestines of Nippostrongylus-infected rats. Immunology (1982) 1.58

Use and effectiveness of hypothermia blankets for febrile patients in the intensive care unit. Clin Infect Dis (1997) 1.57

Immune exclusion and mucus trapping during the rapid expulsion of Nippostrongylus brasiliensis from primed rats. Immunology (1981) 1.56

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. Oncogene (1990) 1.56

Interstitial collagenase is required for angiogenesis in vitro. Dev Biol (1994) 1.55

The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for P- and E-selectins. J Biol Chem (1995) 1.55

Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem (1996) 1.54

Myofibrosarcoma: a clinicopathologic study. Am J Surg Pathol (2001) 1.54

Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract. Am J Surg Pathol (1998) 1.53

Gastric carcinoma presenting with testicular metastasis. Br J Urol (1994) 1.52

Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice. J Immunol (2000) 1.52

Evolution of phosphofructokinase--gene duplication and creation of new effector sites. Nature (1984) 1.52

Prognostic index for extremity soft tissue sarcomas with isolated local recurrence. Ann Surg Oncol (2001) 1.52

Nipple confusion--who is confused? J Pediatr (1996) 1.50

Clinical outcomes of extra-thoracic solitary fibrous tumours. Eur J Surg Oncol (2009) 1.50

Combination carboplatin and radiotherapy in the management of stage II testicular seminoma: comparison with radiotherapy treatment alone. Radiother Oncol (2001) 1.49

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer. Cancer Lett (1995) 1.48

Concomitant detection of mucosal mast cells and eosinophils in the intestines of normal and Nippostrongylus-immune rats. A re-evaluation of histochemical and immunocytochemical techniques. Histochemistry (1984) 1.47

Head and neck liposarcoma. Cancer (1995) 1.45

Mast cell subsets in the rat distinguished immunohistochemically by their content of serine proteinases. Immunology (1986) 1.45

In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes. Hum Gene Ther (1996) 1.45

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity. Science (1984) 1.44

Real-time DNA binding measurements of the ETS1 recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms. Protein Sci (1994) 1.44

Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults. Eur J Endocrinol (1997) 1.43

Comparison of two porcine (Sus scrofa domestica) skin models for in vivo near-infrared laser exposure. Comp Med (2000) 1.43

Interaction of drugs with calmodulin. Biochemical, pharmacological and clinical implications. Biochem Pharmacol (1982) 1.43

Reducing time in bed after cardiac catheterization (TIBS II) Am J Crit Care (1996) 1.43

Anaphylactic release of mucosal mast cell protease and its relationship to gut permeability in Nippostrongylus-primed rats. Immunology (1984) 1.43

Modern vaccines. Parasitic diseases. Lancet (1990) 1.41

FDA, off-label use, and informed consent: debunking myths and misconceptions. Food Drug Law J (1998) 1.40

Amplification, storage, and replication of libraries. Methods Enzymol (1987) 1.39

Amino acid sequence of a mouse mucosal mast cell protease. Biochemistry (1989) 1.39

Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis. Science (1980) 1.39

Hormone-sensitive adenyl cyclase: cytochemical localization in rat liver. Science (1970) 1.39

Primary hyperparathyroidism: an unusual cause of cervical myelopathy. A case report. J Bone Joint Surg Am (2001) 1.38

Outpatient vulval biopsy--a note of caution. Br J Obstet Gynaecol (1995) 1.38

Molecular basis for sequence-specific DNA alkylation by CC-1065. Biochemistry (1988) 1.37

Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J Exp Med (1995) 1.37

Limitations of surgery in the treatment of retroperitoneal sarcoma. Br J Surg (1991) 1.36

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta. J Cell Biol (1990) 1.35

A psychophysiological study of nightmares and night terrors. The suppression of stage 4 night terrors with diazepam. Arch Gen Psychiatry (1973) 1.35