pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.

PubWeight™: 1.83‹?› | Rank: Top 3%

🔗 View Article (PMID 10322110)

Published in Curr Biol on May 06, 1999

Authors

B G Novitch1, D B Spicer, P S Kim, W L Cheung, A B Lassar

Author Affiliations

1: Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School 240 Longwood Avenue, Boston, Massachusetts, 02115, USA.

Articles citing this

Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41

Tailoring to RB: tumour suppressor status and therapeutic response. Nat Rev Cancer (2008) 3.16

p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol (2000) 2.96

Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol (2004) 2.26

A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J (2001) 2.23

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J (2007) 2.21

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. EMBO J (2004) 2.05

Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl Acad Sci U S A (2006) 1.78

IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol (2008) 1.76

Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74

Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev (2006) 1.73

Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol (2007) 1.70

The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev (2000) 1.59

Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. Mol Cell Biol (2005) 1.48

A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol (2000) 1.40

The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development (2005) 1.37

RB1, development, and cancer. Curr Top Dev Biol (2011) 1.37

Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc Natl Acad Sci U S A (2002) 1.36

Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J (2001) 1.34

Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts. Mol Cell Biol (2004) 1.30

Defining the transcriptional signature of skeletal muscle stem cells. J Anim Sci (2007) 1.28

A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells. J Cell Biol (2004) 1.25

p53 regulates myogenesis by triggering the differentiation activity of pRb. J Cell Biol (2000) 1.25

Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts? Cell Div (2007) 1.22

Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol (2005) 1.16

Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift. J Cell Biol (2010) 1.15

MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation. Mol Cell Biol (2006) 1.11

MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. Mol Cell Biol (2003) 1.10

E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev (2009) 1.07

DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06

Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol Cell Biol (2004) 1.06

The retinoblastoma protein is linked to the activation of Ras. Mol Cell Biol (1999) 1.05

Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol (2003) 1.03

G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol (2010) 1.02

Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci (2010) 1.01

pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation. Mol Cell Biol (2007) 0.94

Adult myogenesis in Drosophila melanogaster can proceed independently of myocyte enhancer factor-2. Genetics (2005) 0.93

14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. Nucleic Acids Res (2001) 0.91

A critical role for thrombin in vertebrate lens regeneration. Philos Trans R Soc Lond B Biol Sci (2004) 0.90

Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha. PLoS One (2013) 0.90

Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol (2009) 0.88

Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression. Mol Cell Biol (2009) 0.87

Reflections on lineage potential of skeletal muscle satellite cells: do they sometimes go MAD? Crit Rev Eukaryot Gene Expr (2007) 0.86

Selection of a dominant negative retinoblastoma protein (RB) inhibiting satellite myoblast differentiation implies an indirect interaction between MyoD and RB. Mol Cell Biol (2000) 0.85

Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease. Cell Mol Life Sci (2012) 0.83

Rb1cc1 is critical for myoblast differentiation through Rb1 regulation. Virchows Arch (2005) 0.82

Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. J Biol Chem (2014) 0.82

Cell cycle regulation in hair cell development and regeneration in the mouse cochlea. Cell Cycle (2008) 0.82

CMF1-Rb interaction promotes myogenesis in avian skeletal myoblasts. Dev Dyn (2008) 0.81

Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation. Cell Signal (2012) 0.81

Critical role of the Rb family in myoblast survival and fusion. PLoS One (2011) 0.81

Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. PLoS One (2013) 0.80

Multiple novel functions of lamina associated polypeptide 2α in striated muscle. Nucleus (2011) 0.80

Activation of alpha1A-adrenergic receptor promotes differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype. BMC Cell Biol (2004) 0.79

Signal-dependent fra-2 regulation in skeletal muscle reserve and satellite cells. Cell Death Dis (2013) 0.79

Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program. Biochim Biophys Acta (2009) 0.79

RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling. Plant Cell (2013) 0.78

Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis. EMBO Rep (2015) 0.76

Transcriptional profiling of mesenchymal stromal cells from young and old rats in response to Dexamethasone. BMC Genomics (2006) 0.76

Cell Differentiation and Checkpoint. Int J Cancer Res Mol Mech (2015) 0.75

SWI/SNF-directed stem cell lineage specification: dynamic composition regulates specific stages of skeletal myogenesis. Cell Mol Life Sci (2016) 0.75

Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun (2015) 0.75

Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway. J Virol (2016) 0.75

Articles by these authors

Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17

Core structure of gp41 from the HIV envelope glycoprotein. Cell (1997) 16.18

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell (1989) 14.24

X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science (1991) 10.81

A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science (1993) 10.16

HIV entry and its inhibition. Cell (1998) 9.42

Mechanisms of viral membrane fusion and its inhibition. Annu Rev Biochem (2001) 8.96

A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell (1993) 8.26

Evidence that the leucine zipper is a coiled coil. Science (1989) 8.00

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell (1990) 7.94

A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nat Struct Biol (1995) 7.30

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A (1989) 7.19

Transcription of class III genes: formation of preinitiation complexes. Science (1983) 6.79

MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science (1988) 6.78

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev (2001) 6.28

Predicting coiled coils by use of pairwise residue correlations. Proc Natl Acad Sci U S A (1995) 5.94

MultiCoil: a program for predicting two- and three-stranded coiled coils. Protein Sci (1997) 5.92

Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79

Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding. Annu Rev Biochem (1982) 5.45

Retrovirus envelope domain at 1.7 angstrom resolution. Nat Struct Biol (1996) 4.49

Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev (2001) 4.41

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proc Natl Acad Sci U S A (1998) 4.34

Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28

Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science (1989) 4.23

Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science (1995) 4.06

Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions. Science (1990) 3.93

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2000) 3.92

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell (1992) 3.83

Reexamination of the folding of BPTI: predominance of native intermediates. Science (1991) 3.63

Influenza hemagglutinin is spring-loaded by a metastable native conformation. Proc Natl Acad Sci U S A (1997) 3.57

High-resolution protein design with backbone freedom. Science (1998) 3.54

Protein design of an HIV-1 entry inhibitor. Science (2001) 3.38

Measurement of the beta-sheet-forming propensities of amino acids. Nature (1994) 3.36

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature (1997) 3.35

Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell (1986) 3.34

Peptide 'Velcro': design of a heterodimeric coiled coil. Curr Biol (1993) 3.32

Crystal structure of an isoleucine-zipper trimer. Nature (1994) 3.30

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket. Cell (1999) 3.29

Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A (1999) 3.23

Tests of the helix dipole model for stabilization of alpha-helices. Nature (1987) 3.19

A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev (1997) 3.18

Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution. Science (1997) 3.13

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev (1998) 3.01

Squamous cell carcinoma of the renal pelvis. J Urol (1987) 2.86

Modular structure of transcription factors: implications for gene regulation. Cell (1991) 2.80

A salt bridge stabilizes the helix formed by isolated C-peptide of RNase A. Proc Natl Acad Sci U S A (1982) 2.71

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol (1996) 2.71

A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil. Biochemistry (1995) 2.63

Structural characterization of the human respiratory syncytial virus fusion protein core. Proc Natl Acad Sci U S A (2000) 2.58

A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry (1995) 2.57

Context is a major determinant of beta-sheet propensity. Nature (1994) 2.53

Measurement of interhelical electrostatic interactions in the GCN4 leucine zipper. Science (1995) 2.53

Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proc Natl Acad Sci U S A (1998) 2.46

Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science (1996) 2.42

Context-dependent secondary structure formation of a designed protein sequence. Nature (1996) 2.42

Sequence-specific DNA binding by a short peptide dimer. Science (1990) 2.39

Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev (1999) 2.34

NMR structure of the 35-residue villin headpiece subdomain. Nat Struct Biol (1997) 2.27

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev (1995) 2.22

Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region. Proc Natl Acad Sci U S A (2001) 2.20

A thermostable 35-residue subdomain within villin headpiece. J Mol Biol (1996) 2.17

Subdomain folding of the coiled coil leucine zipper from the bZIP transcriptional activator GCN4. Biochemistry (1994) 2.16

Identification of D-peptide ligands through mirror-image phage display. Science (1996) 2.12

Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci U S A (2000) 2.11

Nature of the charged-group effect on the stability of the C-peptide helix. Proc Natl Acad Sci U S A (1985) 2.09

Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev (1999) 2.08

MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc Natl Acad Sci U S A (1990) 2.07

A trimeric structural subdomain of the HIV-1 transmembrane glycoprotein. J Biomol Struct Dyn (1997) 2.04

A conditional lethal mutant of Escherichia coli which affects the processing of ribosomal RNA. J Biol Chem (1978) 2.00

Electrostatic screening of charge and dipole interactions with the helix backbone. Science (1993) 1.95

Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. Biochemistry (1990) 1.86

Induction of avian cardiac myogenesis by anterior endoderm. Development (1995) 1.85

Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system. Blood (1985) 1.79

Wnt signals from the neural tube block ectopic cardiogenesis. Genes Dev (2001) 1.79

Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell (1997) 1.79

LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins. J Mol Biol (1999) 1.78

Internal stark effect measurement of the electric field at the amino terminus of an alpha helix. Science (1992) 1.78

Radiofrequency sacroiliac joint denervation for sacroiliac syndrome. Reg Anesth Pain Med (2001) 1.77

A residue-specific NMR view of the non-cooperative unfolding of a molten globule. Nat Struct Biol (1997) 1.76

A buried polar interaction can direct the relative orientation of helices in a coiled coil. Biochemistry (1998) 1.74

A peptide model of a protein folding intermediate. Nature (1988) 1.68

Construction of a Z-DNA-specific restriction endonuclease. Proc Natl Acad Sci U S A (1997) 1.67

Repacking protein cores with backbone freedom: structure prediction for coiled coils. Proc Natl Acad Sci U S A (1995) 1.64

Bleeding peptic ulcer: a prospective evaluation of risk factors for rebleeding and mortality. World J Surg (1990) 1.63

Buried polar residues in coiled-coil interfaces. Biochemistry (2001) 1.62

Dissection of a retrovirus envelope protein reveals structural similarity to influenza hemagglutinin. Curr Biol (1995) 1.60

A helix stop signal in the isolated S-peptide of ribonuclease A. Nature (1984) 1.58

A novel myoblast enhancer element mediates MyoD transcription. Mol Cell Biol (1992) 1.58

Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain. Science (1996) 1.56

Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B. J Biol Chem (1992) 1.56

Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol (1996) 1.56

X-ray scattering indicates that the leucine zipper is a coiled coil. Proc Natl Acad Sci U S A (1991) 1.51

Potassium permanganate poisoning--a rare cause of fatal self poisoning. J Accid Emerg Med (1997) 1.51

Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor. Nat Struct Biol (1996) 1.47

Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase. Nature (1993) 1.47