Published in J Physiol on June 01, 1999
The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science (2009) 2.49
Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl) (2004) 1.66
Pharmacology and therapeutic potential of sigma(1) receptor ligands. Curr Neuropharmacol (2008) 1.55
The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus. J Physiol (2006) 1.40
Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol (2000) 1.26
The sigma receptor: evolution of the concept in neuropsychopharmacology. Curr Neuropharmacol (2005) 1.16
Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems. Am J Physiol Cell Physiol (2009) 1.13
Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells. J Mol Signal (2007) 1.01
Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol (2010) 0.97
Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands. Brain Res (2012) 0.91
The oligomeric states of the purified sigma-1 receptor are stabilized by ligands. J Biol Chem (2014) 0.89
Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. J Pharmacol Exp Ther (2014) 0.83
Sigma receptors [σRs]: biology in normal and diseased states. J Recept Signal Transduct Res (2015) 0.78
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels. PLoS One (2012) 0.76
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther (1976) 9.13
Neuroactive steroids. FASEB J (1992) 3.41
Differential signal transduction by five splice variants of the PACAP receptor. Nature (1993) 3.38
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science (1988) 3.01
A proposal for the classification of sigma binding sites. Trends Pharmacol Sci (1992) 2.65
Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron (1997) 2.20
Presynaptic inhibition in the hippocampus. Trends Neurosci (1993) 2.20
Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals. Proc Natl Acad Sci U S A (1991) 2.12
Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J Pharmacol Exp Ther (1982) 1.97
Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol (1993) 1.89
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell (1997) 1.83
Two types of calcium channels coexist in peptide-releasing vertebrate nerve terminals. Neuron (1989) 1.71
Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun (1997) 1.66
Rapid exocytosis and endocytosis in nerve terminals of the rat posterior pituitary. J Physiol (1996) 1.32
Phosphorylation and dephosphorylation modulate a Ca(2+)-activated K+ channel in rat peptidergic nerve terminals. J Physiol (1994) 1.29
Reversible fatigue of stimulus-secretion coupling in the rat neurohypophysis. J Physiol (1984) 1.29
Intraterminal recordings from the rat neurohypophysis in vitro. J Physiol (1990) 1.27
Action potentials and frequency-dependent secretion in the mouse neurohypophysis. Neuroendocrinology (1986) 1.25
Three potassium channels in rat posterior pituitary nerve terminals. J Physiol (1992) 1.23
The effect of dopamine on neurohypophysial hormone release in vivo and from the rat neural lobe and hypothalamus in vitro. J Physiol (1976) 1.20
A calcium-activated potassium channel causes frequency-dependent action-potential failures in a mammalian nerve terminal. J Neurophysiol (1993) 1.17
Molecular neurobiology of dopaminergic receptors. Int Rev Neurobiol (1993) 1.11
Effects of stimulus frequency and potassium channel blockade on the secretion of vasopressin and oxytocin from the neurohypophysis. Neuroendocrinology (1987) 1.08
A three-state receptor model of agonist action. Trends Pharmacol Sci (1997) 1.07
Neurochemical regulation of oxytocin secretion in lactation. Endocr Rev (1992) 1.04
Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci (1994) 1.02
Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary. Endocrinology (1989) 1.01
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist. J Med Chem (1996) 1.01
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther (1997) 0.99
Delineating biochemical and functional properties of sigma receptors: emerging concepts. Crit Rev Neurobiol (1993) 0.98
Organization and ultrastructural identification of the catecholamine nerve terminals in the neural lobe and pars intermedia of the rat pituitary. Z Zellforsch Mikrosk Anat (1972) 0.95
Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors. Mol Pharmacol (1997) 0.94
Passive current flow and morphology in the terminal arborizations of the posterior pituitary. J Neurophysiol (1993) 0.94
Excitatory and inhibitory dopaminergic regulation of oxytocin secretion in the lactating rat: evidence for respective mediation by D-1 and D-2 dopamine receptor subtypes. Neuroendocrinology (1991) 0.90
Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. Endocrinology (1995) 0.89
Coexisting peptides in hypothalamic neuroendocrine systems: some functional implications. Cell Mol Neurobiol (1989) 0.85
Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors. J Neurochem (1994) 0.85
Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells. Br J Pharmacol (1995) 0.84
Neuroactive steroids modulate GABAA receptors in peptidergic nerve terminals. J Neuroendocrinol (1994) 0.84
Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor. J Pharmacol Exp Ther (1991) 0.83
Presynaptic excitability. Int Rev Neurobiol (1995) 0.83
Dopamine D4 receptor mediated inhibition of potassium current in neurohypophysial nerve terminals. J Pharmacol Exp Ther (1998) 0.83
Modulation of [3H]Dopamine release from rat nucleus accumbens by neuropeptide Y may involve a sigma1-like receptor. J Pharmacol Exp Ther (1998) 0.82
Neuropeptide Y and JO 1784, a selective sigma ligand, alter intestinal ion transport through a common, haloperidol-sensitive site. Eur J Pharmacol (1990) 0.81
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. J Neuropsychiatry Clin Neurosci (1996) 0.81
The dopaminergic innervation of the intermediate lobe and of the neural lobe of the pituitary gland. Med Biol (1985) 0.80
Haloperidol-induced syndrome of inappropriate secretion of antidiuretic hormone. Clin Pharmacol Ther (1979) 0.80
D2L, D2S, and D3 dopamine receptors stably transfected into NG108-15 cells couple to a voltage-dependent potassium current via distinct G protein mechanisms. Synapse (1996) 0.78
Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats. Eur J Pharmacol (1990) 0.77
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature (2001) 8.95
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science (1995) 5.74
Successive openings of the same acetylcholine receptor channel are correlated in open time. Biophys J (1983) 3.98
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol (1994) 3.88
Cloning and expression of a rat D2 dopamine receptor cDNA. Nature (1989) 3.59
Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg (1986) 3.54
Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity (1999) 3.43
Spontaneous openings of the acetylcholine receptor channel. Proc Natl Acad Sci U S A (1984) 3.34
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J (1998) 3.13
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
Interferon-dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells. Proc Natl Acad Sci U S A (1982) 3.11
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol (2001) 3.11
Modulation of insulin activities by leptin. Science (1996) 2.92
Kinetics of unliganded acetylcholine receptor channel gating. Biophys J (1986) 2.83
Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles. Science (2001) 2.73
The human interferon alpha/beta receptor: characterization and molecular cloning. Cell (1994) 2.63
A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet (1998) 2.44
A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity. J Biol Chem (1989) 2.35
Soluble cytokine receptors are present in normal human urine. J Exp Med (1989) 2.24
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A (1993) 2.24
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet (2000) 2.24
Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron (1997) 2.20
Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. FEBS Lett (1994) 2.17
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord (2001) 2.08
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A (2000) 2.03
Human leukocyte interferon: production, purification to homogeneity, and initial characterization. Proc Natl Acad Sci U S A (1979) 2.03
Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol (1998) 2.00
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood (1996) 1.99
In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. J Histochem Cytochem (1994) 1.95
5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Neuron (1988) 1.95
Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons. J Neurosci (1982) 1.92
Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci (1998) 1.91
Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell (1997) 1.91
Unexpected power-law stress relaxation of entangled ring polymers. Nat Mater (2008) 1.91
Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol (1993) 1.89
IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc Natl Acad Sci U S A (2000) 1.86
Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin. Proc Natl Acad Sci U S A (1977) 1.86
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell (1997) 1.83
Single cholinergic receptor channel currents in cultured human muscle. J Neurosci (1982) 1.79
Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons. J Neurosci (1987) 1.70
Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proc Natl Acad Sci U S A (1996) 1.70
Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci (1999) 1.69
Phase transitions of the purple membranes of Halobacterium halobium. Biochemistry (1978) 1.66
Cloning and expression of human and rat D1 dopamine receptors. Nature (1990) 1.65
Trace amine-associated receptors and their ligands. Br J Pharmacol (2006) 1.63
A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms. J Physiol (1994) 1.62
Adaptation of Ca(2+)-triggered exocytosis in presynaptic terminals. Neuron (1996) 1.60
Single postsynaptic channel currents in tissue cultured muscle. Nature (1980) 1.58
Characterisation of programmed cell death during aerenchyma formation induced by ethylene or hypoxia in roots of maize (Zea mays L.). Planta (2001) 1.57
A novel alpha subunit in rat brain GABAA receptors. Neuron (1989) 1.51
Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest (2001) 1.51
Physiological properties of abscission accelerator from senescent leaves. Nat New Biol (1972) 1.49
Orphanin FQ is a functional anti-opioid peptide. Neuroscience (1996) 1.48
Adenosine-activated potassium conductance in cultured striatal neurons. Proc Natl Acad Sci U S A (1985) 1.48
Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin. Proc Natl Acad Sci U S A (1977) 1.47
The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6. Blood (1988) 1.47
Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell (1985) 1.44
Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. J Neurochem (1999) 1.43
Two distinct pituitary cell lines from mouse intermediate lobe tumors: a cell that produces prolactin-regulating factor and a melanotroph [seecomments]. Endocrinology (1997) 1.43
Stochastic behavior of a many-channel membrane system. Biophys J (1985) 1.43
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation. Biochemistry (1993) 1.42
GABA-activated chloride channels in secretory nerve endings. Science (1993) 1.42
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem (1991) 1.41
A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine (2001) 1.41
Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat Neurosci (1998) 1.39
Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics (1991) 1.38
Human leukocyte interferon: isolation and characterization of several molecular forms. Arch Biochem Biophys (1981) 1.38
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.37
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more. Trends Neurosci (1998) 1.34
3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation. J Comp Physiol B (2007) 1.33
Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. J Neurosci (1986) 1.33
Rapid exocytosis and endocytosis in nerve terminals of the rat posterior pituitary. J Physiol (1996) 1.32
The secreted tumor-associated antigen 90K is a potent immune stimulator. J Biol Chem (1994) 1.32
Monoclonal antibodies to human interferon-gamma: production, affinity purification and radioimmunoassay. EMBO J (1983) 1.31
D2 dopamine receptor gene and obesity. Int J Eat Disord (1994) 1.30
Dynamic aspects of alcoholic fermentation of rice seedlings in response to anaerobiosis and to complete submergence: relationship to submergence tolerance. Ann Bot (2003) 1.30
Complete nucleotide sequence of a chicken H2b histone gene. J Biol Chem (1982) 1.30
Monoclonal antibodies to human alpha-interferon and their use for affinity chromatography. J Immunol (1982) 1.30
Amino acid sequence of a human leukocyte interferon. Proc Natl Acad Sci U S A (1981) 1.29
Phosphorylation and dephosphorylation modulate a Ca(2+)-activated K+ channel in rat peptidergic nerve terminals. J Physiol (1994) 1.29
Binding assay for opioid peptides with neuroblastoma x glioma hybrid cells: specificity of the receptor site. Brain Res (1978) 1.29
Ethylene-promoted adventitious rooting and development of cortical air spaces (aerenchyma) in roots may be adaptive responses to flooding in Zea mays L. Planta (1979) 1.28
Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol (1997) 1.28
Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J Biol Chem (1995) 1.27
Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol (2000) 1.26