PubRank

R D Cone

Author PubWeight™ 114.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997 11.35
2 Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001 8.95
3 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997 6.80
4 High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range. Proc Natl Acad Sci U S A 1984 5.89
5 The cloning of a family of genes that encode the melanocortin receptors. Science 1992 4.64
6 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994 3.88
7 Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 1993 3.84
8 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 1999 3.26
9 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000 2.90
10 Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector. Mol Cell Biol 1987 2.77
11 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 2001 2.32
12 Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A 1993 2.24
13 Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. J Biol Chem 1992 2.23
14 The central melanocortin system can directly regulate serum insulin levels. Endocrinology 2000 2.09
15 Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 1995 1.92
16 Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997 1.91
17 A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes. Nat Genet 1997 1.81
18 The melanocortin receptors: lessons from knockout models. Neuropeptides 2002 1.61
19 Role of the central melanocortin system in cachexia. Cancer Res 2001 1.60
20 Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 1996 1.52
21 Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses. Science 1986 1.38
22 Genetic models of obesity and energy balance in the mouse. Annu Rev Genet 2000 1.37
23 Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 1997 1.34
24 Molecular and pharmacological characterization of dominant black coat color in sheep. Mamm Genome 1999 1.34
25 Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997 1.31
26 Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology 1999 1.31
27 Small nuclear ribonucleoprotein complexes of Drosophila melanogaster. Proc Natl Acad Sci U S A 1982 1.30
28 Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol 1995 1.29
29 A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways. Anal Biochem 1995 1.26
30 Differentiation of Clostridium botulinum types A, B, and E by pyrolysis-gas-liquid chromatography. Appl Microbiol 1970 1.25
31 Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones. J Neurosci 1996 1.22
32 Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen. Mol Cell Biol 1988 1.20
33 Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Biochemistry 2001 1.19
34 Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 1996 1.12
35 ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines. Mol Cell Endocrinol 1994 1.11
36 Leptin and inflammation-associated cachexia in chronic kidney disease. Kidney Int 2006 1.09
37 Agouti and agouti-related protein: analogies and contrasts. J Biol Chem 2000 1.08
38 Identification of common polymorphisms in the coding sequence of the human MSH receptor (MCIR) with possible biological effects. Hum Mutat 1997 1.05
39 Central melanocortins and the regulation of weight during acute and chronic disease. Recent Prog Horm Res 2001 1.03
40 Tissue-specific expression of functionally rearranged lambda 1 Ig gene through a retrovirus vector. Science 1987 1.00
41 Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note. Neuroendocrinology 2000 0.99
42 Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol Endocrinol 1990 0.98
43 A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor. Mol Endocrinol 1998 0.98
44 Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line. Neuroendocrinology 2001 0.94
45 Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology 1999 0.93
46 3',5'-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line. Mol Endocrinol 1992 0.92
47 Thyrotropin receptor messenger ribonucleic acid is expressed in most brown and white adipose tissues in the guinea pig. Endocrinology 1992 0.90
48 Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides 2000 0.90
49 Differential effects of melanocortin peptides on neural melanocortin receptors. Mol Pharmacol 1994 0.90
50 Knockout models resulting in the development of obesity. Trends Genet 2001 0.89
51 Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mamm Genome 1994 0.89
52 Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci U S A 1998 0.89
53 Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. Am J Physiol 1998 0.89
54 Energy expenditure in obese children with pseudohypoparathyroidism type 1a. Int J Obes (Lond) 2012 0.89
55 High efficiency gene transfer into murine T cell clones using a retroviral vector. J Immunol 1986 0.85
56 Transcriptional induction of the melanocyte-stimulating hormone receptor in brain metastases of murine K-1735 melanoma. Cancer Res 1995 0.83
57 Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn. J Med Chem 1999 0.82
58 The corticotropin-releasing hormone system and feeding behavior--a complex web begins to unravel. Endocrinology 2000 0.82
59 Melanocortin pathway: animal models of obesity and disease. Ann Endocrinol (Paris) 2002 0.81
60 Cloning and expression of a 5HT7 receptor from Xenopus laevis. Receptors Channels 1995 0.80
61 Retroviral-mediated transfer and expression of human beta-globin genes in cultured murine and human erythroid cells. J Biol Chem 1988 0.77
62 The ups and downs of leptin action. Endocrinology 1999 0.75
63 Evidence for aggregation center induction by the ionophore A23187 in the cellular slime mold Polysphondylium violaceum. Exp Cell Res 1980 0.75
64 High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range. 1984. Biotechnology 1992 0.75
65 The interaction of signal transduction pathways in FRTL5 thyroid follicular cells: studies with stable expression of beta 2-adrenergic receptors. Endocrinology 1991 0.75