PubRank

P Polakis

Author PubWeight™ 112.62‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996 9.12
2 Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997 8.99
3 Association of the APC gene product with beta-catenin. Science 1993 8.20
4 Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 1995 7.31
5 Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus. Science 2000 7.25
6 Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 1998 5.78
7 The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 1996 4.56
8 The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 1999 4.06
9 The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 1999 3.95
10 Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol Cell Biol 1996 3.76
11 The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 1994 3.57
12 IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J 1996 2.90
13 The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem 1995 2.62
14 Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol 1991 2.40
15 Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell 1992 2.32
16 Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell 1991 2.26
17 Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol 1990 2.25
18 GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents. Science 1992 2.09
19 Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol Cell Biol 1996 1.94
20 Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res 1997 1.91
21 A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett 1999 1.88
22 Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene 1997 1.83
23 ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. Cell 1990 1.67
24 Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J Biol Chem 1996 1.50
25 Structural basis of the Axin-adenomatous polyposis coli interaction. EMBO J 2000 1.42
26 Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res 2001 1.40
27 Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J Biol Chem 2001 1.39
28 Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene 2006 1.35
29 A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo. Proc Natl Acad Sci U S A 1997 1.30
30 Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol Cell Biol 1992 1.29
31 Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage. Cell Growth Differ 1997 1.29
32 Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J Cell Biol 1997 1.25
33 The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling. J Biol Chem 1999 1.10
34 The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein. Cell 1996 1.03
35 Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk. J Biol Chem 1999 0.98
36 Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1. J Biol Chem 1996 0.97
37 Regulation of ras p21 by GTPase activating proteins. Cold Spring Harb Symp Quant Biol 1991 0.87
38 Regulation of the GTPase activity of the ras-related rap2 protein. Biochem Biophys Res Commun 1992 0.85
39 Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae. Mol Cell Biol 1992 0.85
40 Association of a tyrosine kinase activity with GAP complexes in v-src transformed fibroblasts. Oncogene 1992 0.83
41 Phosphorylation of Rap1GAP during the cell cycle. Biochem Biophys Res Commun 1994 0.83
42 Purification of baculovirus-produced Rap1 GTPase-activating protein. Methods Enzymol 1995 0.81
43 Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. Oncogene 1999 0.81
44 A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange. Int J Pept Protein Res 1991 0.79