R Gussio

Author PubWeight™ 13.73^‹?›

Top papers

Rank	Title	Journal	Year	PubWeight™‹?›
1	A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.	Proc Natl Acad Sci U S A	2000	2.20
2	Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.	Eur J Biochem	2000	1.93
3	Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.	J Med Chem	1999	1.47
4	Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.	Cancer Res	1999	1.41
5	Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.	Bioorg Med Chem Lett	2009	1.18
6	A posttranslational modification of beta-actin contributes to the slow dissociation of the spectrin-protein 4.1-actin complex of irreversibly sickled cells.	J Cell Biol	1995	0.94
7	Chemical synthesis and biological properties of pyridine epothilones.	Chem Biol	2000	0.93
8	Biochemical genetic analysis of indanocine resistance in human leukemia.	Cancer Res	2001	0.83
9	Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target.	Pharmacol Ther	1999	0.83
10	2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.	Bioorg Med Chem Lett	2000	0.81
11	Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones.	Chembiochem	2001	0.77
12	Cortical EEG changes during the self-administration of phencyclinoids.	Neuropharmacology	1989	0.76
13	Cross-resistance analysis and molecular modeling of nonnucleoside reverse transcriptase inhibitors targeting drug-resistance mutations in the reverse transcriptase of human immunodeficiency virus.	Leukemia	1997	0.75