PubRank

M T Keating

Author PubWeight™ 169.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995 11.62
2 A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995 10.18
3 Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 1996 9.77
4 SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995 7.73
5 Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 2000 7.50
6 Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001 7.47
7 Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996 7.35
8 Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998 7.26
9 MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999 5.49
10 Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nat Genet 1993 5.09
11 Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 1995 4.48
12 Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat Genet 1997 3.90
13 Fast inactivation causes rectification of the IKr channel. J Gen Physiol 1996 3.88
14 Elastin is an essential determinant of arterial morphogenesis. Nature 1998 3.56
15 Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. N Engl J Med 1998 3.41
16 Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 1998 3.22
17 The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis. Cell 1993 2.99
18 Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation 2000 2.95
19 Dedifferentiation of mammalian myotubes induced by msx1. Cell 2000 2.72
20 Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A 1996 2.63
21 Molecular basis of the long-QT syndrome associated with deafness. N Engl J Med 1997 2.57
22 LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Cell 1996 2.44
23 Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics 1996 2.44
24 Novel arterial pathology in mice and humans hemizygous for elastin. J Clin Invest 1998 2.41
25 Roles for Fgf signaling during zebrafish fin regeneration. Dev Biol 2000 2.36
26 The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet 2004 2.33
27 Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet 1995 2.30
28 Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res 1996 2.29
29 Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circ Res 1996 2.05
30 Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Genomics 1998 1.93
31 Long QT syndrome associated with syndactyly identified in females. Am J Cardiol 1995 1.93
32 Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. Circulation 1996 1.86
33 Impaired distal airway development in mice lacking elastin. Am J Respir Cell Mol Biol 2000 1.82
34 Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem 1999 1.82
35 Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis. Hum Mol Genet 1997 1.77
36 Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies. J Biol Chem 1987 1.76
37 Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome. Am J Hum Genet 1995 1.68
38 Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. J Clin Invest 1994 1.54
39 Mapping a cardiomyopathy locus to chromosome 3p22-p25. J Clin Invest 1996 1.52
40 Induction of lef1 during zebrafish fin regeneration. Dev Dyn 2000 1.48
41 A novel human gene, WSTF, is deleted in Williams syndrome. Genomics 1998 1.47
42 Assessment of polymorphism in zebrafish mapping strains. Genome Res 1999 1.37
43 Mammalian myotube dedifferentiation induced by newt regeneration extract. Proc Natl Acad Sci U S A 2001 1.37
44 Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. Am J Physiol 1997 1.37
45 Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem 1999 1.33
46 Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation. J Biol Chem 1988 1.31
47 Functional effects of mutations in KvLQT1 that cause long QT syndrome. J Cardiovasc Electrophysiol 1999 1.23
48 A novel human gene FKBP6 is deleted in Williams syndrome. Genomics 1998 1.21
49 ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. J Biol Chem 2000 1.10
50 Relation between outer and luminal diameter in cannulated arteries. Am J Physiol 1999 1.08
51 Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes. Hum Genet 1998 1.06
52 Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. J Neurooncol 1990 0.92
53 Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation 2001 0.90
54 Molecular cloning, characterization, and genomic localization of a human potassium channel gene. Genomics 1992 0.86
55 Dinucleotide repeat polymorphism at the KCNA5 locus. Hum Mol Genet 1993 0.84
56 Hematological status and pregnancy outcomes. Am J Clin Nutr 1981 0.83
57 Negative chemotaxis in cellular slime molds. J Bacteriol 1977 0.82
58 George M. Cober Lecturer: Mark T. Keating. Molecular basis of the long-QT syndrome associated with deafness. Proc Assoc Am Physicians 1997 0.77
59 Isolation of P1 insert ends by direct sequencing. Biotechniques 1994 0.77
60 Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics 1997 0.75
61 Signal transduction by the platelet-derived growth factor receptor. Cold Spring Harb Symp Quant Biol 1988 0.75
62 The platelet-derived growth factor system. Cancer Treat Res 1989 0.75
63 Defining the molecular genetic basis of idiopathic dilated cardiomyopathy. Trends Cardiovasc Med 1997 0.75
64 Molecular characterization and refined genomic localization of three human potassium ion channel genes. Cytogenet Cell Genet 1995 0.75
65 The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. J Cell Physiol Suppl 1987 0.75