PubRank

J M Briggs

Author PubWeight™ 25.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Simulation of enzyme-substrate encounter with gated active sites. Nat Struct Biol 1994 1.93
2 Developing a dynamic pharmacophore model for HIV-1 integrase. J Med Chem 2000 1.71
3 Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge. Biopolymers 1998 1.33
4 Orientational steering in enzyme-substrate association: ionic strength dependence of hydrodynamic torque effects. Eur Biophys J 1996 1.13
5 Correlation between rate of enzyme-substrate diffusional encounter and average Boltzmann factor around active site. Biopolymers 1998 1.10
6 Molecular modeling of the intrastrand guanine-guanine DNA adducts produced by cisplatin and oxaliplatin. Mol Pharmacol 1999 1.08
7 Molecular dynamics studies on the HIV-1 integrase catalytic domain. Biophys J 1999 1.06
8 Mycobacterium celatum infection in a patient with AIDS. Clin Infect Dis 1998 1.03
9 Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA. J Mol Biol 1997 1.02
10 Electrostatic effects in homeodomain-DNA interactions. J Mol Biol 1997 0.96
11 Brownian dynamics simulations of interaction between scorpion toxin Lq2 and potassium ion channel. Biophys J 2001 0.95
12 Calculation of the pKa values for the ligands and side chains of Escherichia coli D-alanine:D-alanine ligase. J Med Chem 1999 0.94
13 Structure-based drug design: computational advances. Annu Rev Pharmacol Toxicol 1997 0.90
14 Brownian and essential dynamics studies of the HIV-1 integrase catalytic domain. J Biomol Struct Dyn 1998 0.89
15 Investigations on human immunodeficiency virus type 1 integrase/DNA binding interactions via molecular dynamics and electrostatics calculations. Pharmacol Ther 2000 0.88
16 Effects of pore mutations and permeant ion concentration on the spontaneous gating activity of OmpC porin. Protein Eng 2000 0.88
17 A model for enzyme-substrate interaction in alanine racemase. J Am Chem Soc 2001 0.88
18 Binding of tacrine and 6-chlorotacrine by acetylcholinesterase. Biopolymers 1996 0.87
19 Poisson-Boltzmann model studies of molecular electrostatic properties of the cAMP-dependent protein kinase. Eur Biophys J 1999 0.86
20 Similarities in the HIV-1 and ASV integrase active sites upon metal cofactor binding. Biopolymers 2000 0.85
21 Ionization state and molecular docking studies for the macrophage migration inhibitory factor: the role of lysine 32 in the catalytic mechanism. J Mol Recognit 2000 0.83
22 Docking of 4-oxalocrotonate tautomerase substrates: implications for the catalytic mechanism. Biopolymers 1999 0.79
23 Internal dynamics and ionization states of the macrophage migration inhibitory factor: comparison between wild-type and mutant forms. Biopolymers 2002 0.78
24 Comparative molecular field analysis (coMFA) study of epothilones-tubulin depolymerization inhibitors: pharmacophore development using 3D QSAR methods. J Comput Aided Mol Des 2001 0.78
25 Discovery of HIV-1 integrase inhibitors through a novel combination of ligand and structure-based drug design. Med Chem 2005 0.76
26 Conservative and nonconservative mutations in proteins: anomalous mutations in a transport receptor analyzed by free energy and quantum chemical calculations. Protein Sci 1995 0.75
27 Pollution in Poullaouen. Technol Cult 1997 0.75
28 Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J Med Chem 1996 0.75