IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production.

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Published in J Pathol on February 01, 1999

Authors

L Wei1, R Debets, J J Hegmans, R Benner, E P Prens

Author Affiliations

1: Department of Dermatology, General Hospital of the Air Force, Beijing, P.R. China.

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