Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
|
Cell
|
1996
|
7.46
|
2
|
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
|
Nature
|
1999
|
3.57
|
3
|
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.
|
Nature
|
1990
|
3.11
|
4
|
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
|
Leukemia
|
2012
|
3.04
|
5
|
Characterization of the human cysteinyl leukotriene 2 receptor.
|
J Biol Chem
|
2000
|
2.89
|
6
|
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.
|
Cancer Res
|
1995
|
2.74
|
7
|
5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.
|
J Exp Med
|
1993
|
1.95
|
8
|
Identification of receptors for neuromedin U and its role in feeding.
|
Nature
|
2000
|
1.60
|
9
|
Discovery and mapping of ten novel G protein-coupled receptor genes.
|
Gene
|
2001
|
1.60
|
10
|
Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis.
|
J Biol Chem
|
1990
|
1.54
|
11
|
Helping patients travel by air.
|
CMAJ
|
1991
|
1.50
|
12
|
Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor.
|
Cancer Res
|
2001
|
1.49
|
13
|
Polycistronic mRNAs code for polypeptides of the Vibrio harveyi luminescence system.
|
J Bacteriol
|
1985
|
1.39
|
14
|
Mode of action of phenformin plus ethyloestrenol on fibrinolysis.
|
Lancet
|
1971
|
1.39
|
15
|
Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.
|
Am J Respir Crit Care Med
|
2001
|
1.37
|
16
|
Methodological study and a recommended technique for determining the euglobulin lysis time.
|
J Clin Pathol
|
1968
|
1.33
|
17
|
Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.
|
Biochem Biophys Res Commun
|
1999
|
1.32
|
18
|
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
|
Bioorg Med Chem Lett
|
1999
|
1.30
|
19
|
A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model.
|
Br J Pharmacol
|
2010
|
1.27
|
20
|
Normal development following in vitro fertilization in the cow.
|
Biol Reprod
|
1982
|
1.21
|
21
|
Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis.
|
Clin Exp Allergy
|
2003
|
1.18
|
22
|
Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2.
|
Rheumatology (Oxford)
|
1999
|
1.16
|
23
|
Effect of ethyloestrenol combined with phenformin or with metformin on platelet stickiness and serum-cholesterol in patients with occlusive vascular disease.
|
Lancet
|
1968
|
1.13
|
24
|
Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo.
|
Lancet
|
1969
|
1.13
|
25
|
Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.
|
J Biol Chem
|
1999
|
1.10
|
26
|
Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.
|
Can J Physiol Pharmacol
|
1992
|
1.08
|
27
|
Orphan G protein-coupled receptors in the CNS.
|
Curr Opin Pharmacol
|
2001
|
1.06
|
28
|
Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.
|
J Biol Chem
|
1985
|
1.06
|
29
|
Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist.
|
J Pharmacol Exp Ther
|
2010
|
1.04
|
30
|
Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition.
|
Mol Pharmacol
|
1992
|
0.98
|
31
|
Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.
|
Cancer Res
|
2001
|
0.97
|
32
|
Leukotriene A5 is a substrate and an inhibitor of rat and human neutrophil LTA4 hydrolase.
|
Biochem Biophys Res Commun
|
1985
|
0.96
|
33
|
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.
|
Biochem Pharmacol
|
1996
|
0.96
|
34
|
A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.
|
J Cell Biol
|
1992
|
0.96
|
35
|
5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors.
|
Mol Pharmacol
|
1992
|
0.95
|
36
|
Epidermoid carcinoma of the palate.
|
Am J Surg
|
1981
|
0.91
|
37
|
Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils.
|
Biochim Biophys Acta
|
1985
|
0.90
|
38
|
Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors.
|
Mol Pharmacol
|
1992
|
0.89
|
39
|
Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.
|
J Biol Chem
|
1991
|
0.89
|
40
|
In vitro synthesis of subunits of bacterial luciferase in an Escherichia coli system.
|
J Bacteriol
|
1983
|
0.88
|
41
|
Stage III carcinoma of the breast. A detailed analysis.
|
Ann Surg
|
1980
|
0.88
|
42
|
Activation of leukocyte movement and displacement of [3H]leukotriene B4 from leukocyte membrane preparations by (12R)- and (12S)-hydroxyeicosatetraenoic acid.
|
Biochim Biophys Acta
|
1987
|
0.86
|
43
|
Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP).
|
Clin Pharmacol Ther
|
2010
|
0.83
|
44
|
Effect of hypophysectomy on the proliferation and differentiation of rat bone marrow stromal cells.
|
Am J Physiol
|
1999
|
0.83
|
45
|
Cloning and characterization of the human leukotriene A4 hydrolase gene.
|
Eur J Biochem
|
1995
|
0.83
|
46
|
The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
|
Can J Physiol Pharmacol
|
1989
|
0.83
|
47
|
Leukotriene B3, leukotriene B4 and leukotriene B5; binding to leukotriene B4 receptors on rat and human leukocyte membranes.
|
Prostaglandins
|
1986
|
0.82
|
48
|
Analogs of leukotriene B4: effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors.
|
Prostaglandins
|
1987
|
0.82
|
49
|
Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells.
|
Mol Pharmacol
|
1994
|
0.82
|
50
|
Antibody response in the bovine genital tract to intrauterine infusion of Actinomyces pyogenes.
|
Res Vet Sci
|
1990
|
0.82
|
51
|
A new class of leukotriene biosynthesis inhibitor: the development of MK-0591.
|
J Lipid Mediat
|
1993
|
0.81
|
52
|
Effects of clofibrate on fibrinolysis, platelet stickiness, plasma-fibrinogen, and serum-cholesterol.
|
Lancet
|
1968
|
0.81
|
53
|
Effects on platelet stickiness and fibrinolysis of phenformin combined with ethyloestrenol or stanozolol.
|
Lancet
|
1970
|
0.80
|
54
|
Characterization of monoclonal antibodies against human leukocyte 5-lipoxygenase.
|
Prostaglandins Leukot Essent Fatty Acids
|
1992
|
0.80
|
55
|
Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein.
|
Eur J Pharmacol
|
1994
|
0.80
|
56
|
Coupling of recombinant 5-lipoxygenase and leukotriene A4 hydrolase activities and transcellular metabolism of leukotriene A4 in Sf9 insect cells.
|
Eur J Biochem
|
1993
|
0.80
|
57
|
Malignant melanoma and its precursors. The growing need for early identification.
|
Postgrad Med
|
1986
|
0.79
|
58
|
Dorsomedial hypothalamic lesions alter intake of an imbalanced amino acid diet in rats.
|
J Nutr
|
1998
|
0.79
|
59
|
Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2.
|
J Clin Pharmacol
|
2011
|
0.78
|
60
|
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
|
J Med Chem
|
1995
|
0.78
|
61
|
In vitro fertilization of cow ova.
|
Theriogenology
|
1978
|
0.77
|
62
|
Effects of dorsomedial hypothalamic nuclei lesions on intake of an imbalanced amino acid diet.
|
Am J Physiol
|
1999
|
0.77
|
63
|
Fertilization and early development of cow ova.
|
Biol Reprod
|
1980
|
0.77
|
64
|
Effect of circular motion exercise on bone modeling and bone mass in young rats: an animal model of isometric exercise.
|
J Musculoskelet Neuronal Interact
|
2001
|
0.77
|
65
|
Neutrophil aggregation and chemokinesis assays.
|
Methods Enzymol
|
1988
|
0.77
|
66
|
Creating instructional media to meet the needs of preschool hearing-impaired children with developmental disabilities.
|
Am Ann Deaf
|
1981
|
0.75
|
67
|
In utero conversion of supraventricular tachycardia with digoxin and procainamide at 17 weeks' gestation.
|
Am J Perinatol
|
1992
|
0.75
|
68
|
A Note on the Pathology of Kala-Azar or Beri-Beri of Assam.
|
Ind Med Gaz
|
1892
|
0.75
|
69
|
A Note on the Condition of the Blood in Malaria.
|
Br Med J
|
1888
|
0.75
|
70
|
Regional perinatal care: Kansas/1979.
|
J Kans Med Soc
|
1980
|
0.75
|
71
|
Leukotriene B4 receptors on rat and human neutrophil membranes.
|
Methods Enzymol
|
1988
|
0.75
|
72
|
The lipoxins. Stereochemical identification and determination of their biosynthesis.
|
J Biol Chem
|
1985
|
0.75
|
73
|
The lipoxins: determination of their biosynthesis.
|
Pharmacol Res Commun
|
1986
|
0.75
|
74
|
Radiation absorbed doses to the walls of hollow organs.
|
J Nucl Med
|
1998
|
0.75
|
75
|
Aerobic fitness and emotional arousal: a reply to Zimmerman and Fulton.
|
Percept Mot Skills
|
1982
|
0.75
|
76
|
Studies of retention and stability of a horizontally polymerized bonded phase for reversed-phase liquid chromatography.
|
J Chromatogr A
|
2000
|
0.75
|
77
|
Aerobic fitness and emotional arousal: a further response to Zimmerman and Fulton.
|
Percept Mot Skills
|
1983
|
0.75
|
78
|
Erie, PA, hospital achieves 'productivity without trauma'.
|
Hospitals
|
1984
|
0.75
|
79
|
Structural characterization of the covalent attachment of leukotriene A3 to leukotriene A4 hydrolase.
|
Arch Biochem Biophys
|
1998
|
0.75
|
80
|
Chemical and enzymatic syntheses of lipoxin A: stereochemical assignment of natural lipoxin A and its possible biosynthesis.
|
Adv Prostaglandin Thromboxane Leukot Res
|
1985
|
0.75
|
81
|
Inflammatory effector mechanisms in asthma.
|
Am J Respir Crit Care Med
|
1995
|
0.75
|
82
|
A Note on the Pathology of Kala-Azar, or Beri-Beri, of Assam.
|
Ind Med Gaz
|
1892
|
0.75
|