The mitotic machinery as a source of genetic instability in cancer.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMID 10448116)

Published in Semin Cancer Biol on August 01, 1999

Authors

G A Pihan1, S J Doxsey

Author Affiliations

1: Department of Pathology and Program in Molecu-$blar Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA, 01605, USA.

Articles citing this

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54

Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization. J Cell Biol (1999) 2.49

Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes. Mol Biol Cell (2000) 2.30

Human chromokinesin KIF4A functions in chromosome condensation and segregation. J Cell Biol (2004) 1.81

Epidermal growth factor receptor expression and gene copy number in the risk of oral cancer. Cancer Prev Res (Phila) (2010) 1.80

Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Mol Biol Cell (2004) 1.73

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc Natl Acad Sci U S A (2003) 1.69

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts. Mol Cancer (2006) 1.44

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol Cell Biol (2003) 1.43

Centrosome amplification causes microcephaly. Nat Cell Biol (2013) 1.33

Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction. Cancer Res (2005) 1.28

Inactivation of E2F3 results in centrosome amplification. Cancer Cell (2003) 1.24

Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Mol Cell Biol (2006) 1.21

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. Breast Cancer Res (2005) 1.20

Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol Cell Biol (2008) 1.20

RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation. BMC Cell Biol (2009) 1.15

Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis. Neoplasia (2001) 1.02

The mammalian centrosome and its functional significance. Histochem Cell Biol (2008) 1.01

Aneuploidy and malignancy: an unsolved equation. J Clin Pathol (2004) 1.00

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer (2007) 0.97

Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer. Front Oncol (2013) 0.96

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer (2011) 0.96

Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death. Cell Oncol (2009) 0.94

Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation. Am J Pathol (2001) 0.93

Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer. Neoplasia (2008) 0.91

PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing. Cell Death Dis (2012) 0.90

Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer. Oncogene (2007) 0.83

Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells. Cell Div (2012) 0.83

Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer. Crit Rev Oncol Hematol (2009) 0.83

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers. J Gastroenterol (2012) 0.80

Imaging genome abnormalities in cancer research. Cell Chromosome (2004) 0.80

Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. Environ Mol Mutagen (2009) 0.80

Immunohistochemical Assessment of Expression of Centromere Protein-A (CENPA) in Human Invasive Breast Cancer. Cancers (Basel) (2011) 0.78

Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy. Chem Res Toxicol (2010) 0.77

DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy. Oncotarget (2016) 0.76

A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis. Math Biosci (2005) 0.75

Growth, progression and chromosome instability of Neuroblastoma: a new scenario of tumorigenesis? BMC Cancer (2017) 0.75

Anaphase-Promoting Complex 7 is a Prognostic Factor in Human Colorectal Cancer. Ann Coloproctol (2017) 0.75

Articles by these authors

Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J Cell Biol (1998) 4.23

Centrosome defects and genetic instability in malignant tumors. Cancer Res (1998) 3.32

Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res (2001) 2.66

An efficient method for introducing macromolecules into living cells. J Cell Biol (1985) 2.60

Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization. J Cell Biol (1999) 2.49

Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle. J Cell Biol (1990) 2.48

Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes. Mol Biol Cell (2000) 2.30

Inhibition of endocytosis by anti-clathrin antibodies. Cell (1987) 2.17

Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem (2000) 1.82

Amorphous no longer: the centrosome comes into focus. Curr Opin Cell Biol (1999) 1.64

Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr Biol (2000) 1.64

Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila. J Cell Biol (1997) 1.63

Centrosomes as command centres for cellular control. Nat Cell Biol (2001) 1.27

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes. J Cell Physiol (1994) 1.27

Heat shock causes protein aggregation and reduced protein solubility at the centrosome and other cytoplasmic locations. Int J Hyperthermia (1997) 1.25

Centrosomal deployment of gamma-tubulin and pericentrin: evidence for a microtubule-nucleating domain and a minus-end docking domain in certain mouse epithelial cells. Cell Motil Cytoskeleton (1997) 1.24

Molecular chaperones and the centrosome. A role for TCP-1 in microtubule nucleation. J Biol Chem (1996) 1.21

Rapid isolation of centrosomes. Methods Enzymol (1998) 1.18

Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles. Traffic (2000) 1.14

Phosphorylation of NUMA occurs during nuclear breakdown and not mitotic spindle assembly. J Cell Sci (1995) 1.08

Heat shock alters centrosome organization leading to mitotic dysfunction and cell death. J Cell Physiol (1993) 0.99

Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc Natl Acad Sci U S A (1997) 0.99

Purification of nuclei from a flagellate protozoan, Trypanosoma brucei. Anal Biochem (1982) 0.95

Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment. J Biol Chem (1996) 0.91

Nucleation and capture of large cell surface-associated microtubule arrays that are not located near centrosomes in certain cochlear epithelial cells. J Anat (1998) 0.90

Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. Eur J Cell Biol (1995) 0.87

Centrosome dynamics in living cells. Methods Cell Biol (1999) 0.87

Thermotolerant cells possess an enhanced capacity to repair heat-induced alterations to centrosome structure and function. J Cell Physiol (1995) 0.83

Methods for the study of pericentrin in centrosome assembly and function. Methods Cell Biol (2001) 0.79