PubRank

K Kirschner

Author PubWeight™ 64.20‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural conservation in parallel beta/alpha-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis. Biochemistry 1991 2.06
2 2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability. Structure 1995 1.83
3 Multifunctional proteins. Annu Rev Biochem 1976 1.78
4 Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo. Science 1989 1.76
5 Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli. Proc Natl Acad Sci U S A 1987 1.49
6 A fully active variant of dihydrofolate reductase with a circularly permuted sequence. Biochemistry 1992 1.48
7 Prediction of secondary structure by evolutionary comparison: application to the alpha subunit of tryptophan synthase. Proteins 1987 1.29
8 The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc Natl Acad Sci U S A 1999 1.26
9 Protein-decorated micelle structure of sodium-dodecyl-sulfate--protein complexes as determined by neutron scattering. Eur J Biochem 1990 1.24
10 Reversible dissociation and unfolding of aspartate aminotransferase from Escherichia coli: characterization of a monomeric intermediate. Biochemistry 1990 1.18
11 Improving the catalytic activity of a thermophilic enzyme at low temperatures. Biochemistry 2000 1.15
12 The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol 2002 1.15
13 X-ray small-angle scattering of yeast glyceraldehyde-3-phosphate dehydrogenase as a function of saturation with nicotinamide-adenine-dinucleotide. Eur J Biochem 1971 1.08
14 Phosphoribosyl anthranilate isomerase from Thermotoga maritima is an extremely stable and active homodimer. Protein Sci 1996 1.06
15 Phosphoribosyl anthranilate isomerase catalyzes a reversible amadori reaction. Biochemistry 1995 1.03
16 (Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima. EMBO J 1995 1.03
17 Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability. Biochemistry 1997 1.01
18 Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase. I. Equilibrium and temperature-jump studies at pH 8-5 and 40 degrees C. J Mol Biol 1971 1.01
19 Limited proteolysis of N-(5'-phosphoribosyl)anthranilate isomerase: indoleglycerol phosphate synthase from Escherichia coli yields two different enzymically active, functional domains. J Mol Biol 1980 1.00
20 The importance of surface loops for stabilizing an eightfold beta alpha barrel protein. Protein Sci 1992 0.98
21 The hyperthermostable indoleglycerol phosphate synthase from Thermotoga maritima is destabilized by mutational disruption of two solvent-exposed salt bridges. J Mol Biol 1999 0.96
22 Stable substructures of eightfold beta alpha-barrel proteins: fragment complementation of phosphoribosylanthranilate isomerase. Biochemistry 1992 0.95
23 The mechanism of binding of L-serine to tryptophan synthase from Escherichia coli. Eur J Biochem 1983 0.94
24 An 8-fold beta alpha barrel protein with redundant folding possibilities. Protein Eng 1990 0.94
25 The tryptophan synthase from Escherichia coli. An improved purification procedure for the alpha-subunit and binding studies with substrate analogues. Eur J Biochem 1975 0.93
26 Significant improvement to the catalytic properties of aspartate aminotransferase: role of hydrophobic and charged residues in the substrate binding pocket. Biochemistry 1994 0.93
27 The catalytic mechanism of tryptophan synthase from Escherichia coli. Kinetics of the reaction of indole with the enzyme--L-serine complexes. Eur J Biochem 1983 0.92
28 Calibration of stopped-flow spectrophotometers using a two-step disulfide exchange reaction. Anal Biochem 1980 0.92
29 Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima. Structure 2000 0.92
30 Purification and characterization of the indole-3-glycerolphosphate synthase/anthranilate synthase complex of Saccharomyces cerevisiae. Eur J Biochem 1985 0.91
31 Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase. II. Stopped-flow studies at pH 8-5 and 40 degrees C. J Mol Biol 1971 0.90
32 The binding of oxidized and reduced nicotinamide adenine-dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase. Eur J Biochem 1972 0.90
33 Phosphoribosylanthranilate isomerase-indoleglycerol-phosphate synthase from Escherichia coli. Methods Enzymol 1987 0.89
34 N-(5-Phosphoribosyl)anthranilate isomerase-indoleglycerol-phosphate synthase. 1. A substrate analogue binds to two different binding sites on the bifunctional enzyme from Escherichia coli. Biochemistry 1979 0.88
35 Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli. Protein Sci 1998 0.88
36 Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains. Biochemistry 1995 0.88
37 [Purity criteria for the crystallizable isoenzyme of D-glyceraldehyde-3-phosphate dehydrogenase from baker's yeast]. Hoppe Seylers Z Physiol Chem 1968 0.88
38 Tryptophan synthase from Saccharomyces cerevisiae is a dimer of two polypeptide chains of Mr 76000 each. Eur J Biochem 1979 0.87
39 Modification of a catalytically important residue of indoleglycerol-phosphate synthase from Escherichia coli. FEBS Lett 1989 0.87
40 The mechanism of tryptophan binding to tryptophan synthase from Escherichia coli. Eur J Biochem 1981 0.86
41 Purification, characterization and crystallization of thermostable anthranilate phosphoribosyltransferase from Sulfolobus solfataricus. Eur J Biochem 2001 0.86
42 Autonomous folding and coenzyme binding of the excised pyridoxal 5'-phosphate binding domain of aspartate aminotransferase from Escherichia coli. Biochemistry 1991 0.85
43 Mechanism of the physiological reaction catalyzed by tryptophan synthase from Escherichia coli. Biochemistry 1991 0.85
44 Purification and characterization of yeast anthranilate phosphoribosyltransferase. Eur J Biochem 1989 0.85
45 The role of the TRP1 gene in yeast tryptophan biosynthesis. J Biol Chem 1988 0.84
46 The mechanism of the synthesis of indoleglycerol phosphate catalyzed by tryptophan synthase from Escherichia coli. Steady-state kinetic studies. Eur J Biochem 1976 0.84
47 The crystal structure of indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength. J Mol Biol 1996 0.83
48 N-(5-Phosphoribosyl)anthranilate isomerase-indoleglycerol-phosphate synthase. 2. Fast-reaction studies show that a fluorescent substrate analogue binds independently to two different sites. Biochemistry 1979 0.82
49 Cooperative and noncooperative binding of pyridoxal 5'-phosphate to tryptophan synthase from Escherichia coli. Biochemistry 1976 0.81
50 A histidine gene cluster of the hyperthermophile Thermotoga maritima: sequence analysis and evolutionary significance. Extremophiles 1998 0.81
51 Collapsed intermediates in the reconstitution of dimeric aspartate aminotransferase from Escherichia coli. Eur J Biochem 1992 0.81
52 Steady-state kinetic studies of the synthesis of indoleglycerol phosphate catalyzed by the alpha subunit of tryptophan synthase from Escherichia coli. Comparison with the alpha2 beta2-complex. Eur J Biochem 1976 0.80
53 X-ray small-angle scattering of yeast glyceraldehyde-3-phosphate dehydrogenase as a function of saturation with nicotinamide-adenine-dinucleotide. FEBS Lett 1969 0.80
54 The domain structure of tryptophan synthase. A neutron scattering study. Eur J Biochem 1985 0.79
55 Improving the prediction of secondary structure of 'TIM-barrel' enzymes. Protein Eng 1991 0.78
56 Small-angle X-ray scattering studies of tryptophan synthase from Escherichia coli and its alpha and beta 2 subunits. Eur J Biochem 1982 0.78
57 Use of homologous sequences to improve protein secondary structure prediction. Methods Enzymol 1991 0.78
58 The binding of indole to the alpha-subunit and beta2-subunit and to the alpha2beta2-complex of tryptophan synthase from Escherichia coli. Identification of a second indole-binding site on the alpha-subunit. Eur J Biochem 1976 0.77
59 Comparison of monovalent and trivalent live attenuated influenza vaccines in young children. J Infect Dis 1993 0.77
60 Identification of three sites of proteolytic cleavage in the hinge region between the two domains of the beta 2 subunit of tryptophan synthase of Escherichia coli or Salmonella typhimurium. Biochemistry 1986 0.77
61 Mechanism of reconstitution of the apo beta 2 subunit and the alpha 2 apo beta 2 complex of tryptophan synthase with pyridoxal 5'-Phosphate: kinetic studies. Biochemistry 1980 0.77
62 Subunit interactions of tryptophan synthase from Escherichia coli as revealed by binding studies with pyridoxal phosphate analogues. Biochemistry 1980 0.77
63 Deletion mutagenesis as a test of evolutionary relatedness of indoleglycerol phosphate synthase with other TIM barrel enzymes. FEBS Lett 1997 0.77
64 Recombinant human erythropoietin: effect on the functional performance of anemic orthopedic patients. Arch Phys Med Rehabil 1996 0.76
65 The quaternary structure of tryptophan synthase from Escherichia coli. Fluorescence and hydrodynamic studies. Eur J Biochem 1983 0.76
66 Autonomous folding of the excised coenzyme-binding domain of D-glyceraldehyde 3-phosphate dehydrogenase from Thermotoga maritima. Protein Sci 1994 0.75
67 The mechanism of self-assembly of the multi-enzyme complex tryptophan synthase from Escherichia coli. EMBO J 1984 0.75
68 [Structural flexibility and enzyme function]. Naturwissenschaften 1969 0.75
69 Effectiveness of the Humphrey Vision Analyzer low vision slide on the partially sighted. Am J Optom Physiol Opt 1983 0.75
70 [Delayed balloon dilatation of the coronary arteries after thrombolytic therapy in acute myocardial infarct: a comparison with thrombolytic therapy]. Ter Arkh 1991 0.75
71 Socially-assisted dying and people with disabilities: some emerging legal, medical, and policy implications. Ment Phys Disabil Law Rep 1997 0.75
72 The predicted secondary structure of the G-type glutamine amidotransferase is compatible with TIM-barrel topology. Protein Eng 1995 0.75
73 Allosteric regulation of enzyme activity. An introduction to the molecular basis of and the experimental approaches to the problem. Curr Top Microbiol Immunol 1968 0.75
74 Introduction to conference transcript: Socially-Assisted Dying: Media, Money & Meaning. Cornell J Law Public Policy 1998 0.75
75 Phosphoribosylanthranilate isomerase and indoleglycerol-phosphate synthase: tryptophan biosynthetic enzymes from Thermotoga maritima. Methods Enzymol 2001 0.75
76 [Regulation of enzyme activity]. Arzneimittelforschung 1967 0.75
77 Kinetics of cooperative ligand binding to the apo beta 2 subunit of tryptophan synthase and its modulation by the alp ha subunit. Biochemistry 1980 0.75
78 [Assembly and function of organized enzymes (author's transl)]. Arzneimittelforschung 1977 0.75
79 Affinity chromatography of tryptophan synthase from Escherichia coli. Systematic studies with immobilized tryptophanol phosphate. Eur J Biochem 1979 0.75
80 Crystallization and preliminary X-ray studies of an aspartate aminotransferase mutant from Escherichia coli. J Mol Biol 1989 0.75
81 [Deficiencies in health care. Health services research--bridge between medical quality assurance and financing crisis]. Herz 2001 0.75