Published in Development on October 01, 1999
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev (2002) 2.55
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol (2010) 2.47
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci U S A (2005) 2.02
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
The Hedgehog signal transduction network. Sci Signal (2012) 1.80
The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev (2000) 1.75
Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev Cell (2007) 1.58
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol (2008) 1.48
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development (2011) 1.48
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev (2003) 1.44
Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep (2013) 1.18
A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics (2005) 1.14
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol (2002) 1.14
At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells. Bioessays (2011) 1.11
Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res (2013) 1.06
Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development (2012) 1.03
Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol (2004) 1.02
Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J (2014) 1.01
Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell (2011) 0.97
Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. J Biol Chem (2006) 0.96
TIE-DYE: a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster. Development (2013) 0.91
A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation. Mol Cell Biol (2008) 0.90
Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila. Genetics (2001) 0.90
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Dev Dyn (2013) 0.83
The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics (2006) 0.83
Distinct posttranscriptional mechanisms regulate the activity of the Zn finger transcription factor lame duck during Drosophila myogenesis. Mol Cell Biol (2006) 0.83
Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing. Dev Biol (2010) 0.82
Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila. Mech Dev (2012) 0.81
CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responses. Nat Commun (2011) 0.80
Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development (2014) 0.79
A quantification of pathway components supports a novel model of Hedgehog signal transduction. J Biol Chem (2009) 0.79
Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient. Development (2013) 0.79
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO Rep (2016) 0.77
Localized JNK signaling regulates organ size during development. Elife (2016) 0.76
Coordinated niche-associated signals promote germline homeostasis in the Drosophila ovary. J Cell Biol (2015) 0.76
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A (2014) 0.76
dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis. PLoS Genet (2016) 0.75
The emerging roles of phosphatases in Hedgehog pathway. Cell Commun Signal (2017) 0.75
Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A. Sci Rep (2017) 0.75
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature (1984) 10.52
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology (1984) 3.50
Tripartite mushroom body architecture revealed by antigenic markers. Learn Mem (1999) 2.22
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell (1995) 2.15
The nuclear location signal. Proc R Soc Lond B Biol Sci (1985) 2.14
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature (1999) 2.11
Deletion loop mutagenesis: a novel method for the construction of point mutations using deletion mutants. Nucleic Acids Res (1982) 1.90
Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature (2001) 1.89
Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory. Neuron (1993) 1.88
Simian virus 40 origin DNA-binding domain on large T antigen. J Virol (1986) 1.80
Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens. Virology (1990) 1.77
Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. FEBS Lett (1989) 1.39
Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes Dev (1993) 1.38
Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development (2000) 1.37
Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains. J Virol (1991) 1.23
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev (1997) 1.18
RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization. Genes Dev (1994) 1.13
Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen. Virology (1988) 1.10
Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function. Mol Cell Biol (1997) 1.09
Effects of a conditional Drosophila PKA mutant on olfactory learning and memory. Learn Mem (1999) 1.08
Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics (1995) 1.00
Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants. J Virol (1988) 0.98
The abnormal location of cytoplasmic SV40 large T is not caused by failure to bind to DNA or to p53. EMBO J (1985) 0.96
Nucleotide sequence of the dihydrofolate reductase gene of methotrexate-resistant Lactobacillus casei. Gene (1985) 0.93
Generation of a novel A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog from a single gene. J Biol Chem (1999) 0.85
Localization and functions of protein kinase A during Drosophila oogenesis. Mech Dev (1995) 0.83