PubRank

M G Cherian

Author PubWeight™ 128.65‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Methallothioneins and their role in the metabolism and toxicity of metals. Life Sci 1978 2.03
2 The secretory pathways of rat serum glycoproteins and albumin. Localization of newly formed proteins within the endoplasmic reticulum. J Cell Biol 1972 1.60
3 Cadmium-metallothionein-induced nephropathy. Toxicol Appl Pharmacol 1976 1.48
4 Clearance of mercury (HG-197, HG-203) vapor inhaled by human subjects. Arch Environ Health 1977 1.31
5 Radioactive mercury distribution in biological fluids and excretion in human subjects after inhalation of mercury vapor. Arch Environ Health 1978 1.24
6 Isolation and purification of cadmium binding proteins from rat liver. Biochem Biophys Res Commun 1974 1.24
7 Biliary excretion of cadmium in rat. I. Dose-dependent biliary excretion and the form of cadmium in the bile. J Toxicol Environ Health 1977 1.18
8 Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development. Dev Biol 1983 1.16
9 The induced synthesis of metallothionein in various tissues of rat in response to metals. I. Effect of repeated injection of cadmium salts. Toxicology 1981 1.14
10 Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. Methods Enzymol 1991 1.14
11 Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney. Toxicology 1982 1.10
12 Metabolism of intravenously injected cadmium-binding protein. Biochem Biophys Res Commun 1975 1.10
13 Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells. Apoptosis 2005 1.07
14 Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development. Pathology 1987 1.05
15 The induced synthesis of metallothionein in various tissues of rats in response to metals. II. Influence of zinc status and specific effect on pancreatic metallothionein. Toxicology 1982 1.03
16 Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice. J Pharmacol Exp Ther 1996 1.02
17 Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation. Cancer 1993 1.01
18 Binding of manganese in human and rat plasma. Biochim Biophys Acta 1985 1.01
19 Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals. Environ Health Perspect 1995 1.00
20 Comparison of tissue distribution of cadmium in mice intravenously injected with metallothionein and a polymer of metallothionein. Toxicology 1983 1.00
21 Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats. Toxicol Sci 2000 0.98
22 Metallothionein in radiation exposure: its induction and protective role. Toxicology 1999 0.98
23 Hepatic copper and metallothionein distribution in Wilson's disease (hepatolenticular degeneration). Lab Invest 1987 0.97
24 Preparation and properties of six rat hemoglobins. Nonuniform biosynthesis in marrow erythroid cells. J Biol Chem 1971 0.97
25 Biliary excretion of cadmium in rat. III. Effects of chelating agents and change in intracellular thiol content on biliary transport and tissue distribution of cadmium. J Toxicol Environ Health 1980 0.95
26 Cellular adaptation in metal toxicology and metallothionein. Toxicology 1983 0.95
27 Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells. Lab Invest 2000 0.95
28 Metallothioneins in brain--the role in physiology and pathology. Toxicol Appl Pharmacol 1997 0.95
29 Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology 1992 0.94
30 Potential role of p53 on metallothionein induction in human epithelial breast cancer cells. Br J Cancer 2002 0.93
31 Metallothionein expression in renal cancer. Urology 1998 0.92
32 Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from northern China. Anticancer Res 1999 0.92
33 Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells. Virchows Arch A Pathol Anat Histopathol 1989 0.92
34 Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder. J Urol 1991 0.92
35 Formation of lead-induced inclusion bodies in primary rat kidney epithelial cell cultures: effect of actinomycin D and cycloheximide. Toxicol Appl Pharmacol 1980 0.92
36 Quantification of metallothioneins by a silver-saturation method. Toxicol Appl Pharmacol 1986 0.92
37 A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation. Biochem J 1993 0.91
38 Hepatic metallothionein as a source of zinc and cysteine during the first year of life. Pediatr Res 1988 0.91
39 Arsenic induces and enhances rat hepatic metallothionein production in vivo. Chem Biol Interact 1992 0.91
40 Cadmium-induced enteropathy: comparative toxicity of cadmium chloride and cadmium-thionein. J Toxicol Environ Health 1977 0.90
41 Absorption and tissue distribution of cadmium in mice after chronic feeding with cadmium chloride and cadmium-metallothionein. Bull Environ Contam Toxicol 1983 0.90
42 Immunohistochemical localization of metallothionein in human thyroid tumors. Am J Pathol 1987 0.90
43 Toxicological significance of metallothionein. Methods Enzymol 1991 0.90
44 Metabolism and potential toxic effects of metallothionein. Experientia Suppl 1979 0.90
45 Regulation of the ontogeny of rat liver metallothionein mRNA by zinc. Eur J Biochem 1987 0.90
46 Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation. Can J Biochem Cell Biol 1985 0.89
47 Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis. Cancer Res 1994 0.89
48 Effects of cadmium and zinc on tissue levels of metallothionein. Environ Health Perspect 1984 0.88
49 Biochemical changes in rat kidney on exposure to elemental mercury vapor: effect on biosynthesis of metallothionein. Chem Biol Interact 1976 0.88
50 Metallothionein and apoptosis during differentiation of myoblasts to myotubes: protection against free radical toxicity. Toxicol Appl Pharmacol 1999 0.88
51 The interactions of cis-diamminedichloroplatinum with metallothionein and glutathione in rat liver and kidney. Toxicology 1990 0.88
52 Ascorbic acid and EDTA treatment of lead toxicity in rats. Life Sci 1979 0.88
53 Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein. J Pharmacol Exp Ther 1993 0.87
54 Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Am J Respir Cell Mol Biol 1994 0.87
55 Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper. Chem Biol Interact 2001 0.86
56 Comparison of metallothionein determination by polarographic and cadmium-saturation methods. Toxicol Appl Pharmacol 1982 0.86
57 Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium-metallothionein in mice. J Toxicol Environ Health 1979 0.85
58 Metallothionein expression in prostatic carcinoma: correlation with Gleason grade, pathologic stage, DNA content and serum level of prostate-specific antigen. Clin Invest Med 1997 0.85
59 Isolation & characterization of a new glycopeptide containing hydroxyproline from human urine. Indian J Biochem 1966 0.85
60 The influence of manganese on the distribution of essential trace elements. II. The tissue distribution of manganese, magnesium, zinc, iron, and copper in rats after chronic manganese exposure. J Toxicol Environ Health 1984 0.85
61 Chelation of cadmium with BAL and DTPA in rats. Nature 1980 0.85
62 Biliary excretion of cadmium in rat. II. The role of metallothionein in the hepatobiliary transport of cadmium. J Toxicol Environ Health 1977 0.85
63 Rat kidney epithelial cell culture for metal toxicity studies. In Vitro Cell Dev Biol 1985 0.85
64 Exposure to different forms of cadmium in mice: differences in metallothionein and alphafetoprotein mRNA induction in liver and kidney. J Biochem Toxicol 1988 0.85
65 Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro. Chem Biol Interact 1995 0.85
66 Chemical modifications of metallothionein. Preparation and characterization of polymers. Biochem J 1984 0.84
67 Metallothionein levels in liver and kidney of Canadians--a potential indicator of environmental exposure to cadmium. Arch Environ Health 1987 0.84
68 Protective effects of metallothionein on streptozotocin-induced diabetes in rats. Life Sci 1994 0.84
69 Metallothionein and apoptosis in the toxic milk mutant mouse. Lab Invest 1998 0.84
70 Metallothionein expression in patients with small cell carcinoma of the lung: correlation with other molecular markers and clinical outcome. Cancer 2001 0.84
71 Quantification of metallothionein by silver saturation. Methods Enzymol 1991 0.83
72 Metallothionein induction in human CNS in vitro: neuroprotection from ionizing radiation. Int J Radiat Biol 2000 0.83
73 Protective role of zinc-metallothionein on DNA damage in vitro by ferric nitrilotriacetate (Fe-NTA) and ferric salts. Chem Biol Interact 1998 0.82
74 Regional distribution of metallothionein, zinc, and copper in the brain of different strains of rats. Biol Trace Elem Res 1999 0.82
75 Cellular localization of metallothionein in the lung following repeated cadmium inhalation. Toxicology 1985 0.82
76 The search for chelate antagonists for chronic cadmium intoxication. Toxicology 1990 0.82
77 Markers of chemoresistance in ovarian carcinomas: an immunohistochemical study of 86 cases. Int J Gynecol Pathol 1996 0.82
78 Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol Appl Pharmacol 1993 0.82
79 Characterization studies on the cadmium-binding proteins from two species of New Zealand oysters. Environ Health Perspect 1986 0.82
80 Immunohistochemical evidence of high concentrations of metallothionein in pancreatic hepatocytes induced by cadmium in rats. Toxicol Pathol 1992 0.82
81 Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma. Histopathology 1998 0.82
82 Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide. Toxicology 2000 0.81
83 High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism. Am J Physiol Cell Physiol 2001 0.81
84 Metabolism of orally administered cadmium-metallothionein in mice. Environ Health Perspect 1979 0.81
85 Chemical modifications of metallothionein, II. Metabolic fate of cadmium bound to metallothionein polymers. Toxicol Lett 1985 0.81
86 Cellular localization of metallothionein in human term placenta. Placenta 1992 0.81
87 Effects of heavy metal cations, sulfhydryl reagents and other chemical agents on striatal D2 dopamine receptors. Biochem Pharmacol 1985 0.81
88 Role of metallothionein in human placenta and rats exposed to cadmium. IARC Sci Publ 1992 0.80
89 Heterogeneity of antibodies to metallothionein isomers and development of a simple enzyme-linked immunosorbent assay. J Biochem Toxicol 1992 0.80
90 The synthesis of metallothionein and cellular adaptation to metal toxicity in primary rat kidney epithelial cell cultures. Toxicology 1980 0.80
91 Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts. Biochem Cell Biol 2000 0.80
92 The influence of manganese on the distribution of essential trace elements. I. Regional distribution of Mn, Na, K, Mg, Zn, Fe, and Cu in rat brain after chronic Mn exposure. Toxicol Appl Pharmacol 1981 0.80
93 Studies on the synthesis and metabolism of zinc-thionein in rats. J Nutr 1977 0.80
94 Ocular copper deposition associated with benign monoclonal gammopathy and hypercupremia. Cornea 1996 0.80
95 Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice. Toxicology 1997 0.79
96 Induction of metallothionein synthesis with preservation of testicular function in rats following long term renal transplantation. Urol Res 2000 0.79
97 Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line. J Pharmacol Exp Ther 1995 0.79
98 Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. Arch Biochem Biophys 2004 0.79
99 Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism. Toxicology 1992 0.79
100 Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Toxicology 1998 0.79
101 Biliary excretion of cadmium in rat. V. Effects of structurally related mercaptans on chelation of cadmium from metallothionein. J Toxicol Environ Health 1982 0.79
102 Correlation between cadmium-induced pulmonary carcinogenicity, metallothionein expression, and inflammatory processes: a species comparison. Environ Health Perspect 1994 0.79
103 Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: effect of pre-exposure to zinc, and copper salts. Mutat Res 1996 0.79
104 Influence of maternal mineral deficiency on the hepatic metallothionein and zinc in newborn rats. Biochem Cell Biol 1986 0.79
105 Immunohistochemical localization of metallothionein. Methods Enzymol 1991 0.79
106 The regional distribution of lead in normal rat brain. Neurotoxicology 1982 0.78
107 Environmental exposure to cadmium and factors affecting trace-element metabolism and metal toxicity. Biol Trace Elem Res 1986 0.78
108 Effects of inhibition of cystathionase activity on glutathione and metallothionein levels in the adult rat. J Biochem Toxicol 1991 0.78
109 Chelation of lead by dimercaptopropane sulfonate and a possible diagnostic use. Toxicol Appl Pharmacol 1984 0.78
110 Radioimmunoassay of metallothionein in rabbit, rat, mouse, Chinese hamster, and human cells. Biol Trace Elem Res 1991 0.78
111 Metallothionein induction and pulmonary responses to inhaled cadmium chloride in rats and mice. Fundam Appl Toxicol 1996 0.78
112 Age dependent changes in metallothionein and accumulation of cadmium in horses. Comp Biochem Physiol C 1989 0.78
113 Chelation of cadmium from metallothionein in vivo and its excretion in rats repeatedly injected with cadmium chloride. J Pharmacol Exp Ther 1982 0.78
114 Metallothionein does not protect mouse endocrine cells from damage induced by alloxan injection. Toxicology 1999 0.78
115 Metabolic changes in glutathione and metallothionein in newborn rat liver. J Pharmacol Exp Ther 1989 0.78
116 A comparative study of the influence of vicinal dithiols and a dithiocarbamate on the biliary excretion of cadmium in rat. Toxicol Appl Pharmacol 1991 0.78
117 Organ-specific metallothionein induction in mice by X irradiation. Radiat Res 1989 0.78
118 Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice. Radiat Res 1998 0.77
119 Nephrotoxicity of repeated injections of cadmium-metallothionein in rats. Toxicol Appl Pharmacol 1993 0.77
120 Metabolism of parenterally administered zinc and cadmium in livers of newborn rats. Chem Biol Interact 1983 0.77
121 Quantification of metallothionein isoforms using an enzyme-linked immunosorbent assay (ELISA) with two specific antisera. Toxicol Appl Pharmacol 1992 0.77
122 Studies on toxicity of metallothionein in rat kidney epithelial cell culture. Dev Toxicol Environ Sci 1982 0.77
123 Liver transplantation induces cytochrome P450 1A1 dependent monooxygenase activity in rat lung and kidney. Can J Physiol Pharmacol 1995 0.77
124 A new glycopeptide containing hydroxyproline and sarcosine in human urine. Biochim Biophys Acta 1965 0.77
125 Gastrointestinal absorption of cadmium and metallothionein. Toxicol Appl Pharmacol 1991 0.77
126 Renal metallothionein metabolism after a reduction of renal mass. II. Effect of zinc pretreatment on the renal toxicity and intrarenal accumulation of inorganic mercury. Toxicology 1992 0.77
127 Induction of metallothionein synthesis by zinc in cadmium pretreated rats. Toxicology 1990 0.77
128 Induction of hepatic metallothionein I in tumour-bearing mice. Br J Cancer 1995 0.77
129 Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis. Cancer Res 1993 0.77
130 Delay of M-phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3-L1 fibroblasts. J Cell Physiol 2000 0.77
131 Chelation of cadmium without increased renal cadmium deposition. Environ Health Perspect 1984 0.77
132 Site of synthesis of metallothionein in rat liver. Can J Biochem 1981 0.77
133 The distribution and excretion of manganese: the effects of manganese dose, L-dopa, and pretreatment with zinc. Toxicol Appl Pharmacol 1982 0.77
134 Metallothionein: a potential marker for differentiating benign and neoplastic gastrointestinal lymphoid infiltrates. Pathology 1997 0.76
135 Induction of renal metallothionein synthesis by parenteral cadmium-thionein in rats. Biochem Pharmacol 1978 0.76
136 Influence of chronic MnCl2 and EDTA treatment on tissue levels and urinary excretion of trace metals in rats. Arch Environ Contam Toxicol 1982 0.76
137 Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration. Can J Physiol Pharmacol 1995 0.76
138 Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney. Chem Biol Interact 1993 0.76
139 Renal effects of repeated administration of calcium disodium ethylenediaminetetraacetate during excessive exposure to lead in rats. J Environ Pathol Toxicol 1979 0.76
140 Mobilization of hepatic cadmium in pregnant rats. Toxicol Appl Pharmacol 1993 0.76
141 Endothelins and their receptors in cirrhotic and neoplastic livers of Canadian and Chinese populations. Anticancer Res 1999 0.76
142 Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry. Mod Pathol 1993 0.76
143 Metallothionein in human gingival amalgam tattoos. Arch Oral Biol 2001 0.75
144 The influence of nutritional deficiencies on gastrointestinal uptake of cadmium and cadmium-metallothionein in rats. Toxicology 1995 0.75
145 Exogenous metallothionein and renal toxicity of cadmium and mercury in rats. Toxicology 1992 0.75
146 The reaction of metallothionein with mercuribenzoate. A dialysis and 113Cd-n.m.r. study. Biochem J 1986 0.75
147 Physicochemical and metabolic properties of modified metallothioneins. Environ Health Perspect 1984 0.75
148 Metallothionein protein and mRNA in the toxic milk mouse. Biochem J 1994 0.75
149 Shifts in the dose-effect relationship for the nephropathy induced by cadmium-metallothionein in rats after a reduction in renal mass. J Pharmacol Exp Ther 1992 0.75
150 Mercury-metallothionein and the renal accumulation and handling of mercury. Toxicology 1993 0.75
151 Correlation of parameters of cadmium exposure with onset of cadmium-induced nephropathy in rats. J Environ Pathol Toxicol Oncol 1984 0.75
152 Pregnancy-associated changes in plasma metallothionein concentration and renal cadmium accumulation in rats. Proc Soc Exp Biol Med 1993 0.75
153 Urinary excretion of hydroxyproline in leprosy. Clin Chim Acta 1969 0.75
154 Uptake of cadmium and metallothionein by rat everted intestinal sacs. Toxicol Appl Pharmacol 1989 0.75
155 The interaction of zinc and cadmium in the synthesis of hepatic metallothionein in rats. Toxicology 1985 0.75
156 Immunohistochemical localization of metallothionein in the developing teeth of cadmium-injected rats. Arch Oral Biol 1999 0.75
157 Isolation and partial characterization of a mercury-binding nonhistone protein component from rat kidney nuclei. Biochem Biophys Res Commun 1973 0.75
158 Effects of cadmium-metallothionein on renal organic ion transport and lipid peroxidation in rats. J Biochem Toxicol 1988 0.75
159 Sensitivity to radiation treatment and changes in metallothionein synthesis in a transplanted murine tumor. Radiat Res 1997 0.75
160 The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats. Chem Biol Interact 1992 0.75
161 Effects of dexamethasone injection on body retention and hepatic distribution of zinc, cadmium and metallothionein in newborn rats. Toxicology 1986 0.75
162 Metal complexes of dietary flavonoids: evaluation of radical scavenger properties and protective activity against oxidative stress in vivo. Cell Mol Biol (Noisy-le-grand) 2007 0.75
163 Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats. Biochem Cell Biol 1993 0.75
164 Importance of species differences in experimental pulmonary carcinogenicity of inhaled cadmium for extrapolation to humans. Toxicol Lett 1994 0.75
165 Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide. Toxicol Appl Pharmacol 1994 0.75
166 Ontogenic changes in hepatic glutathione and metallothionein in rats and the effect of a low-sulphur-containing diet. Br J Nutr 1990 0.75
167 Turnover of parenterally administered zinc and cadmium and the redistribution of metallothionein bound zinc in newborn rats. Toxicology 1985 0.75
168 Chelation of lead with DMPS and BAL in rats injected with lead. Bull Environ Contam Toxicol 1983 0.75
169 Radiation exposure does not alter metallothionein III isoform expression in mouse brain. Biol Trace Elem Res 2000 0.75
170 Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats. Toxicol Appl Pharmacol 1989 0.75
171 Effect of ethanol on brain metallothionein in transgenic mice. Alcohol Clin Exp Res 2000 0.75
172 Renal toxicity of cadmium-metallothionein and enzymuria in rats. J Pharmacol Exp Ther 1987 0.75
173 Changes in dietary zinc result in specific alterations of metallothionein concentrations in newborn rat liver. J Nutr 1987 0.75
174 Role of metallothioneins in disease. Ann Clin Lab Sci 1978 0.75
175 Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice. Biochem Cell Biol 1998 0.75
176 Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein. Toxicology 1999 0.75
177 Lack of luminal or basolateral uptake and transepithelial transport of mercury in isolated perfused proximal tubules exposed to mercury-metallothionein. J Toxicol Environ Health 1995 0.75
178 Effects of zinc deficiency on pre-existing cadmium-metallothionein in the pancreas. Toxicology 1984 0.75
179 Biliary excretion of cadmium in rat. VI. Mobilization of cadmium from metallothionein by 2,3-dimercaptopropanol. J Toxicol Environ Health 1980 0.75
180 A spectroscopic study of rat liver and Scylla serrata crab metallothioneins. Biochim Biophys Acta 1984 0.75
181 Changes in brain metallothionen and zinc during development in transgenic mice. Biol Trace Elem Res 1998 0.75