Published in Mol Med Today on October 01, 1999
Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med (2002) 2.83
Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J Virol (2002) 2.41
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. J Biol Chem (2001) 2.03
Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res (2009) 2.00
Molecular pathways in virus-induced cytokine production. Microbiol Mol Biol Rev (2001) 1.97
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut (2002) 1.96
LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. J Exp Med (2005) 1.72
siRNA-based therapy ameliorates glomerulonephritis. J Am Soc Nephrol (2010) 1.58
A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation. PLoS One (2011) 1.34
On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chem Biol Drug Des (2009) 1.30
Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. Biochem J (2002) 1.27
Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol (2005) 1.22
Clinical practice in the new era. A fusion of molecular biology and classical medicine is transforming the way we look at and treat diseases. EMBO Rep (2001) 1.15
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol (2001) 1.12
Redox/ROS regulation of lipopolysaccharide-induced mitogen-activated protein kinase (MAPK) activation and MAPK-mediated TNF-alpha biosynthesis. Br J Pharmacol (2002) 1.11
Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition. Biochem J (2004) 1.08
Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages. Mol Immunol (2007) 1.08
Role of p38 MAPK and NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clin Exp Immunol (2005) 1.07
Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. Br J Pharmacol (2003) 1.06
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc (2016) 1.06
Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis. Bioorg Med Chem (2010) 1.05
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci U S A (2002) 1.04
Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J Extracell Vesicles (2015) 1.02
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem (2012) 0.98
Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. J Clin Endocrinol Metab (2007) 0.97
The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. Br J Pharmacol (2004) 0.96
Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis. Dev Biol (2007) 0.92
Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem J (2002) 0.92
Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets. Pathol Res Pract (2008) 0.89
IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice. Br J Pharmacol (2002) 0.89
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques. Mol Metab (2013) 0.88
p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci Rep (2014) 0.86
Using the one-lung method to link p38 to pro-inflammatory gene expression during overventilation in C57BL/6 and BALB/c mice. PLoS One (2012) 0.86
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific. Br J Pharmacol (2004) 0.86
A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility. Front Genet (2013) 0.86
Tumour necrosis factor-alpha potentiates CR3-induced respiratory burst by activating p38 MAP kinase in human neutrophils. Immunology (2001) 0.86
Over-expression of caveolin-1 aggravate LPS-induced inflammatory response in AT-1 cells via up-regulation of cPLA2/p38 MAPK. Inflamm Res (2010) 0.85
Coronavirus virulence genes with main focus on SARS-CoV envelope gene. Virus Res (2014) 0.84
Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway. Am J Pathol (2004) 0.84
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol (2003) 0.82
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mediates p38 mitogen-activated protein kinase activation and signal transduction in peripheral blood mononuclear cells from patients with lupus nephritis. Inflammation (2012) 0.82
Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-κB and MAP Kinase. Nutr Res Pract (2014) 0.82
Transcriptome analysis on the inflammatory cell infiltration of nonalcoholic steatohepatitis in bama minipigs induced by a long-term high-fat, high-sucrose diet. PLoS One (2014) 0.82
Molecular interaction study of N1-p-fluorobenzyl-cymserine with TNF-α , p38 kinase and JNK kinase. Antiinflamm Antiallergy Agents Med Chem (2013) 0.82
p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene. Drug Metab Dispos (2013) 0.81
The proinflammatory cytokine, IL-6, and its interference with bFGF signaling and PSMA in prostate cancer cells. Inflammation (2013) 0.81
Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Br J Cancer (2003) 0.81
Preferential expression of PAPPA in human preadipocytes from omental fat. J Endocrinol (2014) 0.81
Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expression in CCRF-CEM lymphoblastic cells: evidence for the involvement of cAMP and p38 MAPK. Mediators Inflamm (2003) 0.81
Plasma membrane receptor mediated MAPK signaling pathways are activated in human uterine cervix at parturition. Reprod Biol Endocrinol (2007) 0.79
Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide. J Cardiovasc Magn Reson (2015) 0.79
Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice. J Mol Neurosci (2012) 0.79
The effect of mechanical strain on soft (cardiovascular) and hard (bone) tissues: common pathways for different biological outcomes. Cell Adh Migr (2013) 0.78
Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients (2016) 0.78
Phlorofucofuroeckol A suppresses expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines via inhibition of nuclear factor-κB, c-Jun NH2-terminal kinases, and Akt in microglial cells. Inflammation (2013) 0.77
Strain-specific viral distribution and neuropathology of feline immunodeficiency virus. Vet Immunol Immunopathol (2011) 0.77
Porphyromonas gingivalis lipopolysaccharide activates canonical Wnt/β-catenin and p38 MAPK signalling in stem cells from the apical papilla. Inflammation (2013) 0.77
Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways. Sci Rep (2017) 0.77
Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation. Antimicrob Agents Chemother (2015) 0.76
CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br J Pharmacol (2005) 0.76
A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil. Evid Based Complement Alternat Med (2013) 0.75
Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status. Redox Biol (2016) 0.75
LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR 4 signaling pathway. Acta Pharmacol Sin (2017) 0.75
Surgical site infection after colorectal surgery according to the main anesthetic agent: a retrospective comparison between volatile anesthetics and propofol. Korean J Anesthesiol (2016) 0.75
Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice. J Neurosci (2017) 0.75
Diffuse Large B Cell Lymphoma Cell Line U-2946: Model for MCL1 Inhibitor Testing. PLoS One (2016) 0.75
Leaves of Raphanus sativus L. Shows Anti-Inflammatory Activity in LPS-Stimulated Macrophages via Suppression of COX-2 and iNOS Expression. Prev Nutr Food Sci (2017) 0.75
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B (2017) 0.75
Anti-inflammatory effects of sargachromenol-rich ethanolic extract of Myagropsis myagroides on lipopolysaccharide-stimulated BV-2 cells. BMC Complement Altern Med (2014) 0.75
The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling. Cell Immunol (2015) 0.75
αVβ3 Integrin Regulation of Respiratory Burst in Fibrinogen Adherent Human Neutrophils. Cell Mol Bioeng (2014) 0.75
4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One (2017) 0.75
IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC. Oncotarget (2017) 0.75
Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women. JAMA (1994) 2.03
Recurrent genital herpes simplex virus infection in pregnancy: infant outcome and frequency of asymptomatic recurrences. Am J Obstet Gynecol (1982) 1.61
Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N Engl J Med (1988) 1.50
Vaginal colonization by Escherichia coli as a risk factor for very low birth weight delivery and other perinatal complications. J Infect Dis (1997) 1.23
Human peritoneal mesothelial cells synthesize interleukin-8. Synergistic induction by interleukin-1 beta and tumor necrosis factor-alpha. Am J Pathol (1993) 1.21
FK-506 and haemolytic uraemic syndrome. Lancet (1990) 1.14
Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29. Br J Pharmacol (1995) 1.08
Long-term developmental follow-up of infants of diabetic mothers. J Pediatr (1994) 1.02
Prevention of preeclampsia: a randomized trial of atenolol in hyperdynamic patients before onset of hypertension. Obstet Gynecol (1999) 1.00
Declining insulin requirement in the late first trimester of diabetic pregnancy. Diabetes Care (2001) 0.95
Increased factor VIII as an index of vascular injury in cyclosporine nephrotoxicity. Transplantation (1986) 0.94
SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Br J Pharmacol (2009) 0.92
Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol (1999) 0.91
Cocaine exposure during pregnancy: improving assessment with radioimmunoassay of maternal hair. Obstet Gynecol (1994) 0.88
Genital herpes during pregnancy: inability to distinguish primary and recurrent infections clinically. Obstet Gynecol (1997) 0.87
Effect of Cyclosporin A on prostacyclin synthesis by vascular tissue. Thromb Res (1983) 0.86
Long-term impairment of suppressor-cell function by cyclophosphamide in minimal-change nephropathy and its association with therapeutic response. Lancet (1981) 0.85
Herpes simplex virus-2 (HSV-2) type-specific antibody correlates of protection in infants exposed to HSV-2 at birth. J Clin Invest (1992) 0.84
Prevention of neonatal herpes. BJOG (2011) 0.83
Cervical antibodies to herpes simplex virus proteins in pregnancy and puerperium: a pilot study. Infect Dis Obstet Gynecol (1996) 0.80
Stress induced suppression of maintenance but not of acquisition of ethanol consumption in rats. Pharmacol Biochem Behav (1983) 0.80
Effect of insulin-dependent diabetes on plasma lipoproteins in diabetic pregnancy. J Reprod Med (1993) 0.78
Depression of normal lymphocyte transformation by sera of patients with minimal change nephropathy and other forms of nephrotic syndrome. Clin Nephrol (1981) 0.78
First trimester serum zinc concentrations in human pregnancy. Am J Clin Nutr (1983) 0.77
Impaired lymphocyte transformation in minimal change nephropathy in remission. Clin Nephrol (1982) 0.77
Impaired lymphocyte and suppressor cell function in minimal change nephropathy, membranous nephropathy and focal glomerulosclerosis. Clin Nephrol (1984) 0.76
Nucleotide levels in peripheral blood mononuclear cells of immunodeficient children: problems of measurement. Adv Exp Med Biol (1984) 0.75
Maternal genital herpes and gender of offspring. Am J Obstet Gynecol (1991) 0.75
Interleukin-1-induced IL-8 and IL-6 gene expression and production in human mesangial cells is differentially regulated by cAMP. Kidney Int (1995) 0.75
Prostacyclin deficiency in a young woman with recurrent thrombosis. Br Med J (Clin Res Ed) (1986) 0.75
Tactual-kinesthetic discrimination shifts in retarded children. J Exp Child Psychol (1967) 0.75
Reversibility of the analgesic effect of meptazinol in volunteers. Postgrad Med J (1983) 0.75
The Diabetes in Early Pregnancy Study: changes in cholesterol, triglycerides, body weight, and blood pressure. The National Institute of Child Health and Human Development--the Diabetes in Early Pregnancy Study. Am J Obstet Gynecol (1992) 0.75
Acyclovir suppression to prevent cesarean delivery after first-episode genital herpes. Obstet Gynecol (1996) 0.75
Effects of catecholamine manipulations on three different self-stimulation behaviors. Pharmacol Biochem Behav (1978) 0.75
Effects of catecholamine manipulations on three different self-stimulation behaviors. Pharmacol Biochem Behav (1978) 0.75
Drug ingestion during pregnancy: infrequent exposure in a contemporary United States sample. National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study Group. Am J Perinatol (1989) 0.75
Combined degree course in mental handicap nursing. There will always be someone who cannot be cared for at home. Nurs Times (1981) 0.75
Eight-and-a-half syndrome: an unusual presentation of brainstem infarction. QJM (2011) 0.75
Consumer-oriented care. Womens Health Issues (1993) 0.75
Endothelium and glomerular growth. Am J Kidney Dis (1991) 0.75
Cyclophosphamide and suppressor cell function. Lancet (1981) 0.75