Significantly lower incidence of cancer among patients with Huntington disease: An apoptotic effect of an expanded polyglutamine tract?

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMID 10506723)

Published in Cancer on October 01, 1999

Authors

S A Sørensen1, K Fenger, J H Olsen

Author Affiliations

1: Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

Articles citing this

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01

Cancer risk among patients with myotonic muscular dystrophy. JAMA (2011) 1.38

Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet (2010) 1.21

Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest (2002) 1.17

Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat Rev Neurosci (2013) 1.11

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles. BMC Med Genet (2011) 1.00

The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling. EMBO Mol Med (2013) 0.91

Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology. Evol Med Public Health (2015) 0.85

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers. PLoS Comput Biol (2015) 0.83

Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases: an update. ScientificWorldJournal (2012) 0.81

Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice. BMC Cell Biol (2005) 0.78

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. PLoS One (2016) 0.77

An Effective Method to Identify Shared Pathways and Common Factors among Neurodegenerative Diseases. PLoS One (2015) 0.76

Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. BMC Neurol (2016) 0.75

Pleomorphic Invasive Ductal Carcinoma of the Breast in a Patient with Huntington's Disease. Case Rep Pathol (2014) 0.75

CAG repeat size in Huntingtin alleles is associated with cancer prognosis. Eur J Hum Genet (2016) 0.75

Comment on Eskenazi et al. Med Hypotheses (2008) 0.75

Articles by these authors

(truncated to the top 100)

The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull (1999) 14.29

Prognosis of cancers associated with venous thromboembolism. N Engl J Med (2000) 4.51

The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med (1998) 4.41

Induced abortion and the risk of breast cancer. N Engl J Med (1997) 4.04

Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst (1997) 3.57

A pooled analysis of magnetic fields and childhood leukaemia. Br J Cancer (2000) 3.49

Risk for subsequent cancer after diagnosis of basal-cell carcinoma. A population-based, epidemiologic study. Ann Intern Med (1996) 3.18

Decreasing late mortality among five-year survivors of cancer in childhood and adolescence: a population-based study in the Nordic countries. J Clin Oncol (2001) 2.48

Rheumatoid arthritis and cancer risk. Eur J Cancer (1996) 2.44

Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. Hum Mutat (1994) 2.44

Appendectomy and subsequent risk of inflammatory bowel diseases. Surgery (2001) 2.35

Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer (1994) 2.33

Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population. Cephalalgia (1996) 2.29

Risk of liver and other types of cancer in patients with cirrhosis: a nationwide cohort study in Denmark. Hepatology (1998) 2.19

Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin. Am J Gastroenterol (2000) 2.18

Malignant tumours and psoriasis: climatotherapy at the Dead Sea. Br J Dermatol (1999) 2.06

A population-based cohort study of the risk of colorectal and other cancers among users of low-dose aspirin. Br J Cancer (2003) 1.88

Risk of cancer among offspring of childhood-cancer survivors. Association of the Nordic Cancer Registries and the Nordic Society of Paediatric Haematology and Oncology. N Engl J Med (1998) 1.87

Autoimmune disease and risk for Parkinson disease: a population-based case-control study. Neurology (2009) 1.86

Non-neoplastic mortality of European workers who produce man made vitreous fibres. Occup Environ Med (1999) 1.83

Air pollution from traffic at the residence of children with cancer. Am J Epidemiol (2001) 1.79

Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol (2002) 1.74

Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ (2000) 1.73

Benign anal lesions and the risk of anal cancer. N Engl J Med (1994) 1.67

Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark. Br J Cancer (2002) 1.59

Incidence of childhood cancer in Denmark 1943-1984. Int J Epidemiol (1989) 1.54

Cancer following breast reduction surgery in Denmark. Cancer Causes Control (1997) 1.50

Crime in Huntington's disease: a study of registered offences among patients, relatives, and controls. J Neurol Neurosurg Psychiatry (1998) 1.49

Non-Hodgkin's lymphoma and other cancers among a cohort of patients with systemic lupus erythematosus. Arthritis Rheum (1997) 1.49

Cancer risk following polymyositis and dermatomyositis: a nationwide cohort study in Denmark. Cancer Causes Control (1995) 1.47

Second malignant neoplasms after cancer in childhood and adolescence: a population-based case-control study in the 5 Nordic countries. The Nordic Society for Pediatric Hematology and Oncology. The Association of the Nordic Cancer Registries. Int J Cancer (2000) 1.46

Effect of omeprazole and cimetidine on prepyloric gastric ulcer: double blind comparative trial. Gut (1988) 1.42

A genetic study of ulcerative colitis. Scand J Gastroenterol (1966) 1.42

Malignant melanoma among lithographers. Scand J Work Environ Health (1996) 1.40

Birth characteristics, sibling patterns, and acute leukemia risk in childhood: a population-based cohort study. J Natl Cancer Inst (1997) 1.39

[Pernicious anemia and risk of cancer in Denmark]. Ugeskr Laeger (1997) 1.39

Risk of breast cancer in men with liver cirrhosis. Am J Gastroenterol (1998) 1.39

Cancer risk and mortality in users of calcium channel blockers. A cohort study. Cancer (2000) 1.36

Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population-based study. Int J Cancer (1996) 1.33

Relationship between cumulative anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. J Clin Oncol (1998) 1.33

Spatial temporal patterns in childhood leukaemia: further evidence for an infectious origin. EUROCLUS project. Br J Cancer (1998) 1.31

Gallstones, cholecystectomy and risk of cancers of the liver, biliary tract and pancreas. Br J Cancer (1999) 1.29

Cancer in patients with ulcerative colitis. Int J Cancer (1995) 1.28

An air pollution model for use in epidemiological studies: evaluation with measured levels of nitrogen dioxide and benzene. J Expo Anal Environ Epidemiol (2000) 1.27

Connective tissue disease and other rheumatic conditions following breast implants in Denmark. Ann Plast Surg (1997) 1.24

Causes of death in patients with Huntington's disease and in unaffected first degree relatives. J Med Genet (1992) 1.24

Acromegaly and cancer risk: a cohort study in Sweden and Denmark. Cancer Causes Control (2002) 1.23

Occurrence of different cancers in patients with Parkinson's disease. BMJ (1995) 1.23

Summary: multiple primary cancers in Denmark, 1943-80. Natl Cancer Inst Monogr (1985) 1.23

Population-based risk estimates of Wilms tumor in sporadic aniridia. A comprehensive mutation screening procedure of PAX6 identifies 80% of mutations in aniridia. Hum Genet (2001) 1.22

Hormone use for menopausal symptoms and risk of breast cancer. A Danish cohort study. Br J Cancer (2005) 1.22

Angiotensin-converting enzyme inhibitors and the risk of cancer: a population-based cohort study in Denmark. Cancer (2001) 1.21

Occupational formaldehyde exposure and increased nasal cancer risk in man. Int J Cancer (1984) 1.20

Cancer and non-cancer mortality of chimney sweeps in Copenhagen. Int J Epidemiol (1982) 1.18

Risk of hospitalization resulting from upper gastrointestinal bleeding among patients taking corticosteroids: a register-based cohort study. Am J Med (2001) 1.18

Cancer risk after splenectomy. Cancer (1995) 1.18

Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families. Hum Mol Genet (1993) 1.15

Mortality from amyotrophic lateral sclerosis, other chronic disorders, and electric shocks among utility workers. Am J Epidemiol (1998) 1.14

Malignant tumours and psoriasis: a follow-up study. Br J Dermatol (1999) 1.13

Formaldehyde induced symptoms in day care centers. Am Ind Hyg Assoc J (1982) 1.13

The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study. Br J Cancer (2004) 1.13

Incidence of intracranial tumors following hospitalization for head injuries (Denmark). Cancer Causes Control (1998) 1.12

The pancreatic function following subtotal pancreatectomy for cancer. Scand J Gastroenterol Suppl (1971) 1.12

Mortality, pathological findings and causes of death in the de Lange syndrome. Acta Paediatr Scand (1985) 1.11

Radiotherapy for childhood cancer and risk for congenital malformations in offspring: a population-based cohort study. Clin Genet (2008) 1.11

Incidence of vestibular schwannoma in Denmark, 1977-1995. Am J Otol (2000) 1.11

Risk factors for renal-cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors. Int J Cancer (1994) 1.11

Cancer incidence among Danish workers exposed to trichloroethylene. J Occup Environ Med (2001) 1.09

Risk of colorectal cancer and other cancers in patients with gall stones. Gut (1996) 1.09

Health outcomes in offspring of mothers with breast implants. Pediatrics (1998) 1.09

Risk of subsequent malignant neoplasms among 1,641 Hodgkin's disease patients diagnosed in childhood and adolescence: a population-based cohort study in the five Nordic countries. Association of the Nordic Cancer Registries and the Nordic Society of Pediatric Hematology and Oncology. J Clin Oncol (1996) 1.08

Risk of colorectal cancer in relatives of patients with inflammatory bowel disease (Denmark) Cancer Causes Control (1998) 1.07

[Screening for lung cancer. Promising results with low-dose CT]. Ugeskr Laeger (2000) 1.07

Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia. Hum Mutat (2000) 1.07

Neurologic disease among women with breast implants. Neurology (1998) 1.06

Formaldehyde and cancer morbidity among male employees in Denmark. Cancer Causes Control (1995) 1.05

Occupational risk factors for renal-cell carcinoma in Denmark. Scand J Work Environ Health (1994) 1.05

Psychological stress, cancer incidence and mortality from non-malignant diseases. Br J Cancer (1997) 1.04

Molecular and behavioral analysis of the R6/1 Huntington's disease transgenic mouse. Neuroscience (2003) 1.04

Clinically overt hereditary hemochromatosis in Denmark 1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients. Ann Hematol (2001) 1.03

Admission for and mortality from primary venous thromboembolism in women of fertile age in Denmark, 1977-95. BMJ (1999) 1.03

Sex ratio among offspring of childhood cancer survivors treated with radiotherapy. Br J Cancer (2003) 1.02

Trends in childhood leukaemia in the Nordic countries in relation to fallout from atmospheric nuclear weapons testing. BMJ (1992) 1.02

Malignancies that occur before and after anal cancer: clues to their etiology. Am J Epidemiol (1994) 1.02

A study of psychiatric morbidity in patients with Huntington's disease, their relatives, and controls. Admissions to psychiatric hospitals in Denmark from 1969 to 1991. Br J Psychiatry (1993) 1.02

Birth order, sibship size and risk of Hodgkin's disease in children and young adults: a population-based study of 31 million person-years. Int J Cancer (1997) 1.01

Cancer in siblings of children with cancer in the Nordic countries: a population-based cohort study. Lancet (2001) 1.01

Risk of cancer among Danish utility workers--a nationwide cohort study. Am J Epidemiol (1998) 1.01

Outcome-oriented cutpoints in analysis of quantitative exposures. Am J Epidemiol (1994) 1.01

ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer. Br J Cancer (2003) 1.00

G(2) chromosomal radiosensitivity in Danish survivors of childhood and adolescent cancer and their offspring. Br J Cancer (2005) 1.00

Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J Cancer (1995) 1.00

Collagenous colitis. Acta Med Scand (1984) 0.99

Testicular cancer risk and maternal parity: a population-based cohort study. Br J Cancer (1998) 0.99

Sex ratios, HLA markers, and rheumatic diseases. Ann Rheum Dis (1992) 0.98

Risk factors for renal cell carcinoma in Denmark. I. Role of socioeconomic status, tobacco use, beverages, and family history. Cancer Causes Control (1994) 0.97

Prevalence of silicone breast implant rupture among Danish women. Plast Reconstr Surg (2001) 0.97

Risk factors for renal cell carcinoma in Denmark: role of medication and medical history. Int J Epidemiol (1994) 0.96

Gender differences in the healthy worker effect among synthetic vitreous fiber workers. Am J Epidemiol (1999) 0.96

Evidence of decreased risk of cancer in individuals with fragile X. Am J Med Genet (2001) 0.96