Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMID 10515868)

Published in Blood on October 15, 1999

Authors

P C Res1, F Couwenberg, F A Vyth-Dreese, H Spits

Author Affiliations

1: Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands.

Articles citing this

BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 3.40

Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J Exp Med (2000) 2.25

Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin Immunopathol (2004) 1.72

Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells. J Exp Med (2000) 1.68

The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J Exp Med (2003) 1.63

Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells. J Clin Invest (2001) 1.61

The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol (2015) 1.52

Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients. Clin Cancer Res (2012) 1.44

Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations. J Exp Med (2004) 1.29

CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions. J Immunol (2009) 1.23

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood (2007) 1.05

Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries? J Exp Med (2000) 0.87

Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro. Retrovirology (2011) 0.87

Stimulated plasmacytoid dendritic cells impair human T-cell development. Blood (2006) 0.85

IFN-α is constitutively expressed in the human thymus, but not in peripheral lymphoid organs. PLoS One (2011) 0.81

The Role of Dendritic Cells in Central Tolerance. Immune Netw (2015) 0.77

BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells. Eur J Immunol (2014) 0.75

Articles by these authors

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med (1991) 9.27

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A (1988) 5.03

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol (1986) 4.30

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods (1984) 3.97

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science (1990) 3.70

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol (1988) 3.65

Selection of a human T helper type 1-like T cell subset by mycobacteria. J Exp Med (1991) 3.41

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A (1997) 3.20

Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol (2001) 2.85

Interleukin-10. Curr Opin Immunol (1992) 2.85

Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen. J Immunol (1985) 2.70

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol (1992) 2.67

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest (1984) 2.46

CD40 is functionally expressed on human thymic epithelial cells. J Immunol (1992) 2.29

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med (1991) 2.27

Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J Exp Med (2000) 2.25

Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3. Eur J Immunol (1985) 2.23

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity. Int Immunol (1992) 2.20

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. J Immunol (1988) 2.16

Recombinant interleukin 4 promotes the growth of human T cells. J Immunol (1987) 2.13

Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med (1997) 2.11

Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments. EMBO J (1988) 2.05

Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med (1993) 1.98

Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev (1988) 1.84

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. J Exp Med (1992) 1.81

Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma (1983) 1.79

Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4. J Immunol (1990) 1.79

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature (1992) 1.76

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity (1999) 1.75

HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol (1984) 1.73

Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95. Eur J Immunol (1985) 1.64

A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Exp Med (1997) 1.59

The developmental relationship between NK cells and T cells. Immunol Today (1992) 1.55

Phase I trial of combined immunotherapy with subcutaneous granulocyte macrophage colony-stimulating factor, low-dose interleukin 2, and interferon alpha in progressive metastatic melanoma and renal cell carcinoma. Clin Cancer Res (2000) 1.53

Both Fc receptors and lymphocyte-function-associated antigen 1 on human T gamma lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity). Eur J Immunol (1984) 1.48

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol (2000) 1.45

A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J Exp Med (1990) 1.41

Genomic organization of the human T-cell antigen-receptor alpha/delta locus. Proc Natl Acad Sci U S A (1988) 1.41

Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones. Nature (1988) 1.41

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model. Gene Ther (2008) 1.40

T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity. Eur J Immunol (1986) 1.40

Characterization of a third form of the human T cell receptor gamma/delta. J Exp Med (1988) 1.38

Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol (1986) 1.35

Antigen recognition by MHC-incompatible cells of a human mismatched chimera. J Exp Med (1988) 1.35

Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells. Science (1986) 1.34

Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. J Immunol (1993) 1.33

Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J Exp Med (1993) 1.32

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells. Blood (1996) 1.31

The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens. J Exp Med (1988) 1.29

Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity. J Immunol (1984) 1.29

The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens. J Immunol (1982) 1.29

Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. J Immunol (1992) 1.29

Natural killer cell clones can efficiently process and present protein antigens. J Immunol (1991) 1.28

Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses. J Immunol (2001) 1.27

Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol (1991) 1.26

IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells. J Immunol (1991) 1.24

Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy. Int Immunol (1991) 1.24

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J (1996) 1.24

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. Leukemia (2007) 1.24

Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development. J Exp Med (1997) 1.23

Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3. Blood (1999) 1.23

TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation. Blood (1999) 1.22

Functionally distinct subsets of human gamma/delta T cells. Eur J Immunol (1991) 1.21

Diversity and organization of human T cell receptor delta variable gene segments. J Exp Med (1989) 1.21

Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. J Immunol (1985) 1.18

Human natural killer cell committed thymocytes and their relation to the T cell lineage. J Exp Med (1993) 1.16

Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera. J Exp Med (1988) 1.16

In situ detection of virus- and tumor-specific T-cell immunity. Nat Med (2000) 1.14

PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice. J Exp Med (1999) 1.13

Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development. Blood (1993) 1.13

CD70 represents the human ligand for CD27. Int Immunol (1994) 1.12

Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells. J Immunol (1989) 1.12

Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset. J Immunol (1991) 1.11

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J (1999) 1.09

Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. J Immunol (1982) 1.08

Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells. J Immunol (1989) 1.07

Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4. Eur J Immunol (1992) 1.07

NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells. Blood (2000) 1.06

Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci. J Immunol (1983) 1.06

Particle-bound enzymes in the bloodstream form of Trypanosoma brucei. Eur J Biochem (1977) 1.05

Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells. Int J Cancer (1986) 1.05

The replacement of monocytes and interleukin-1 by phorbol ester in lectin-induced proliferation of human thymocytes and T cells. Immunobiology (1982) 1.04

IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions. J Immunol (1989) 1.03

A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity. Cell Immunol (1981) 1.02

CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes. Eur J Immunol (1993) 1.01

The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens. J Immunol (1985) 1.01

Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage. J Immunol (1997) 0.99

Developmental stages in the human thymus. Semin Immunol (1999) 0.99

Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A (1991) 0.98

Regulation by anti-CD2 monoclonal antibody of the activation of a human T cell clone induced by anti-CD3 or anti-T cell receptor antibodies. J Immunol (1987) 0.97

A family of T-cell receptor molecules expressed on T-cell clones with different specificities for allomajor histocompatibility antigens. Hum Immunol (1986) 0.97

Comparison of target antigens of monoclonal reagents OKT5, OKT8, and Leu2A, which inhibit effector function of human cytotoxic T lymphocytes. Hybridoma (1983) 0.97

Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol (1999) 0.97

Complexity of T cell receptor recognition sites for defined alloantigens. J Immunol (1987) 0.96

HLA class-II-restricted Mycobacterium leprae-reactive T-cell clones from leprosy patients established with a minimal requirement for autologous mononuclear cells. Scand J Immunol (1986) 0.96

Use of bicistronic retroviral vectors encoding the LacZ gene together with a gene of interest: a method to select producer cells and follow transduced target cells. Cancer Gene Ther (1997) 0.95

Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones. Eur J Immunol (1986) 0.95