Who are the proteolytic culprits in vascular disease?

Molecular bases of the acute coronary syndromes. Circulation (1995) 5.23

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science (1996) 4.22

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A (1998) 3.60

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet (1997) 3.40

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest (1998) 3.17

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc Natl Acad Sci U S A (1995) 2.84

Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol (1996) 2.68

The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem (1998) 2.48

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem (1992) 2.13

Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest (1999) 2.03

Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J (1998) 1.85

Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme. J Biol Chem (1993) 1.49

Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. Arterioscler Thromb Vasc Biol (1998) 1.48

Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ Res (1996) 1.44

Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest (1998) 1.44

Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines. J Vasc Surg (1998) 1.21

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice. Circulation (1999) 1.21

Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein. Hum Gene Ther (1998) 1.20

Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro. Biochem Biophys Res Commun (1995) 1.05

The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. J Vasc Surg (1999) 1.04

Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins. Gene Ther (1998) 0.98

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). J Vasc Surg (1999) 0.98

Mature cathepsin L is substantially active in the ionic milieu of the extracellular medium. Arch Biochem Biophys (1995) 0.90

Pathogenesis of aneurysms. Semin Vasc Surg (1995) 0.80