1
|
Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations.
|
Clin Pharmacol Ther
|
1998
|
2.09
|
2
|
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.
|
Clin Pharmacol Ther
|
1998
|
1.99
|
3
|
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid.
|
Clin Pharmacol Ther
|
1998
|
1.49
|
4
|
Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors.
|
Clin Pharmacol Ther
|
1998
|
1.42
|
5
|
Activated charcoal alone and followed by whole-bowel irrigation in preventing the absorption of sustained-release drugs.
|
Clin Pharmacol Ther
|
2001
|
1.40
|
6
|
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin.
|
Clin Pharmacol Ther
|
1999
|
1.34
|
7
|
The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin.
|
Eur J Clin Pharmacol
|
1998
|
1.33
|
8
|
Interference of dairy products with the absorption of ciprofloxacin.
|
Clin Pharmacol Ther
|
1991
|
1.32
|
9
|
Plasma concentrations of active simvastatin acid are increased by gemfibrozil.
|
Clin Pharmacol Ther
|
2000
|
1.24
|
10
|
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease.
|
Neurology
|
2007
|
1.22
|
11
|
Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide.
|
Clin Pharmacol Ther
|
2001
|
1.19
|
12
|
Effect of itraconazole on the pharmacokinetics of atorvastatin.
|
Clin Pharmacol Ther
|
1998
|
1.13
|
13
|
In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9).
|
Br J Clin Pharmacol
|
2001
|
1.08
|
14
|
Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.
|
Drug Metab Dispos
|
2001
|
1.04
|
15
|
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
|
Drug Metab Dispos
|
2000
|
1.04
|
16
|
Rifampin decreases the plasma concentrations and effects of repaglinide.
|
Clin Pharmacol Ther
|
2000
|
1.04
|
17
|
Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrations.
|
Clin Pharmacol Ther
|
2000
|
1.03
|
18
|
The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.
|
Clin Pharmacol Ther
|
2001
|
1.00
|
19
|
The clinical significance of food-drug interactions: a review.
|
Med J Aust
|
1989
|
1.00
|
20
|
Milk and yoghurt do not impair the absorption of ofloxacin.
|
Br J Clin Pharmacol
|
1992
|
1.00
|
21
|
Grapefruit juice substantially increases plasma concentrations of buspirone.
|
Clin Pharmacol Ther
|
1998
|
0.98
|
22
|
Failure of oral activated charcoal to accelerate the elimination of amiodarone and chloroquine.
|
Hum Exp Toxicol
|
1992
|
0.98
|
23
|
Effect of magnesium hydroxide on the absorption of tolfenamic and mefenamic acids.
|
Eur J Clin Pharmacol
|
1988
|
0.97
|
24
|
Enhanced uptake of doxorubicin into bronchial carcinoma: beta-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site.
|
Cancer Res
|
1997
|
0.95
|
25
|
A prospective study of acute poisonings in Finnish hospital patients.
|
Hum Exp Toxicol
|
1998
|
0.95
|
26
|
Triazolam is ineffective in patients taking rifampin.
|
Clin Pharmacol Ther
|
1997
|
0.94
|
27
|
Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate.
|
Clin Pharmacol Ther
|
2001
|
0.94
|
28
|
Midazolam alpha-hydroxylation by human liver microsomes in vitro: inhibition by calcium channel blockers, itraconazole and ketoconazole.
|
Pharmacol Toxicol
|
1999
|
0.92
|
29
|
Identification of drugs ingested in acute poisoning: correlation of patient history with drug analyses.
|
Ther Drug Monit
|
2000
|
0.92
|
30
|
Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors.
|
Clin Pharmacol Ther
|
1999
|
0.91
|
31
|
Concentrations and effects of buspirone are considerably reduced by rifampicin.
|
Br J Clin Pharmacol
|
1998
|
0.91
|
32
|
Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life.
|
Eur J Clin Pharmacol
|
2000
|
0.90
|
33
|
Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration.
|
Br J Clin Pharmacol
|
1997
|
0.89
|
34
|
Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride.
|
Clin Pharmacol Ther
|
2001
|
0.87
|
35
|
The effect of activated charcoal on the absorption of fluoxetine, with special reference to delayed charcoal administration.
|
Pharmacol Toxicol
|
1996
|
0.87
|
36
|
Effect of sucralfate on absorption of norfloxacin and ofloxacin.
|
Antimicrob Agents Chemother
|
1994
|
0.87
|
37
|
Effect of activated charcoal on the pharmacokinetics of pholcodine, with special reference to delayed charcoal ingestion.
|
Ther Drug Monit
|
1997
|
0.86
|
38
|
Clozapine serum concentrations are lower in smoking than in non-smoking schizophrenic patients.
|
Pharmacol Toxicol
|
1999
|
0.86
|
39
|
The effect of ferrous sulphate on the absorption of norfloxacin, ciprofloxacin and ofloxacin.
|
Br J Clin Pharmacol
|
1994
|
0.86
|
40
|
Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation.
|
Br J Clin Pharmacol
|
2000
|
0.86
|
41
|
Enhancement of drug absorption by antacids. An unrecognised drug interaction.
|
Clin Pharmacokinet
|
1994
|
0.86
|
42
|
Effect of fluconazole on plasma fluvastatin and pravastatin concentrations.
|
Eur J Clin Pharmacol
|
2000
|
0.85
|
43
|
Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of glimepiride.
|
Clin Pharmacol Ther
|
2001
|
0.85
|
44
|
Effect of methylprednisolone on CYP3A4-mediated drug metabolism in vivo.
|
Eur J Clin Pharmacol
|
2001
|
0.84
|
45
|
Efficacy of activated charcoal versus gastric lavage half an hour after ingestion of moclobemide, temazepam, and verapamil.
|
Eur J Clin Pharmacol
|
2000
|
0.84
|
46
|
Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin.
|
Clin Pharmacol Ther
|
2000
|
0.84
|
47
|
The ex-vivo isolated, perfused human lung model: description and potential applications.
|
Thorac Cardiovasc Surg
|
1996
|
0.83
|
48
|
Rifampin reduces plasma concentrations and effects of zolpidem.
|
Clin Pharmacol Ther
|
1997
|
0.83
|
49
|
Different effects of products containing metal ions on the absorption of lomefloxacin.
|
Clin Pharmacol Ther
|
1994
|
0.83
|
50
|
Effect of delayed administration of activated charcoal on the absorption of conventional and slow-release verapamil.
|
J Toxicol Clin Toxicol
|
1997
|
0.82
|
51
|
Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram.
|
Br J Clin Pharmacol
|
1999
|
0.82
|
52
|
Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation.
|
Clin Pharmacol Ther
|
2000
|
0.81
|
53
|
Misleading use of correlation and regression in method-comparison studies of cyclosporine.
|
Clin Chem
|
1993
|
0.81
|
54
|
Effect of rifampicin on the pharmacokinetics and pharmacodynamics of glimepiride.
|
Br J Clin Pharmacol
|
2000
|
0.81
|
55
|
Concentrations and effects of zopiclone are greatly reduced by rifampicin.
|
Br J Clin Pharmacol
|
1997
|
0.80
|
56
|
Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone.
|
Clin Pharmacol Ther
|
2000
|
0.80
|
57
|
Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone.
|
Clin Pharmacol Ther
|
1998
|
0.79
|
58
|
The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone.
|
Eur J Clin Pharmacol
|
1999
|
0.79
|
59
|
The effect of itraconazole on the pharmacokinetics and pharmacodynamics of oral prednisolone.
|
Eur J Clin Pharmacol
|
2000
|
0.79
|
60
|
Pharmacokinetics of diltiazem in massive overdose.
|
Ther Drug Monit
|
1997
|
0.79
|
61
|
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem.
|
Eur J Clin Pharmacol
|
1998
|
0.79
|
62
|
The effect of dexamethasone on the pharmacokinetics of triazolam.
|
Pharmacol Toxicol
|
1998
|
0.78
|
63
|
Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.
|
Pharmacol Toxicol
|
1999
|
0.78
|
64
|
Itraconazole decreases the clearance and enhances the effects of intravenously administered methylprednisolone in healthy volunteers.
|
Pharmacol Toxicol
|
1999
|
0.78
|
65
|
The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations.
|
Br J Clin Pharmacol
|
1991
|
0.77
|
66
|
Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice.
|
Br J Clin Pharmacol
|
2001
|
0.77
|
67
|
Effect of itraconazole on cerivastatin pharmacokinetics.
|
Eur J Clin Pharmacol
|
1999
|
0.77
|
68
|
Lack of effect of terfenadine on the pharmacokinetics of the CYP3A4 substrate buspirone.
|
Pharmacol Toxicol
|
1999
|
0.77
|
69
|
The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect.
|
Clin Pharmacol Ther
|
2000
|
0.77
|
70
|
Prevention of chloroquine absorption by activated charcoal.
|
Hum Exp Toxicol
|
1992
|
0.77
|
71
|
Grapefruit juice can increase the plasma concentrations of oral methylprednisolone.
|
Eur J Clin Pharmacol
|
2000
|
0.77
|
72
|
Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole.
|
Clin Pharmacol Ther
|
1998
|
0.77
|
73
|
Gastric decontamination performed 5 min after the ingestion of temazepam, verapamil and moclobemide: charcoal is superior to lavage.
|
Br J Clin Pharmacol
|
2000
|
0.77
|
74
|
Propafenone for the prevention of atrial tachyarrhythmias after cardiac surgery: a randomized, double-blind placebo-controlled trial.
|
Clin Pharmacol Ther
|
2008
|
0.76
|
75
|
Effects of metronidazole on midazolam metabolism in vitro and in vivo.
|
Eur J Clin Pharmacol
|
2000
|
0.75
|
76
|
Effects of milk and food on the absorption of enoxacin.
|
Br J Clin Pharmacol
|
1995
|
0.75
|
77
|
Activated charcoal for chloroquine poisoning.
|
BMJ
|
1993
|
0.75
|
78
|
Activated charcoal should replace the resins in the treatment of digoxin intoxication!
|
Arch Intern Med
|
1989
|
0.75
|
79
|
Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam.
|
Clin Pharmacol Ther
|
1999
|
0.75
|
80
|
Therapeutic cyclosporine monitoring: comparison of radioimmunoassay and high-performance liquid chromatography methods in organ transplant recipients.
|
Ther Drug Monit
|
1990
|
0.75
|
81
|
The effects of glyceryl trinitrate and nicotinic acid ointments during cold exposure.
|
Pharmacol Toxicol
|
1997
|
0.75
|
82
|
The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron.
|
Clin Pharmacol Ther
|
1999
|
0.75
|
83
|
Quantitative immunohistochemical analysis of the glutathione S-transferase GSTM1: in situ phenotyping in archival material.
|
Xenobiotica
|
1999
|
0.75
|
84
|
Desorption of furosemide from charcoal in vitro and in man.
|
Int J Clin Pharmacol Ther
|
1994
|
0.75
|
85
|
The effect of pH on the in-vitro dissolution of three second-generation sulphonylurea preparations: mechanism of antacid-sulphonylurea interaction.
|
J Pharm Pharmacol
|
1996
|
0.75
|
86
|
The effect of activated charcoal on the absorption and elimination of astemizole.
|
Hum Exp Toxicol
|
1994
|
0.75
|