Published in Biochim Biophys Acta on December 06, 1999
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol (2010) 3.21
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Peroxisome proliferator-activated receptor alpha target genes. PPAR Res (2010) 2.09
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A (2000) 1.83
Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.71
Mechanisms and insights into drug resistance in cancer. Front Pharmacol (2013) 1.70
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J (2006) 1.67
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J (2003) 1.57
The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement. EMBO J (2001) 1.53
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet (2004) 1.51
A class of plant glycosyltransferases involved in cellular homeostasis. EMBO J (2004) 1.45
Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. J Hepatol (2015) 1.44
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS J (2011) 1.41
The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch (2006) 1.40
Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. J Virol (2006) 1.32
Bile formation and secretion. Compr Physiol (2013) 1.32
Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA. Eur Radiol (2012) 1.22
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol Aspects Med (2008) 1.21
The blood-brain barrier in neurodegenerative disease: a rhetorical perspective. J Neurochem (2009) 1.20
Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell (2004) 1.08
Multidrug resistance associated proteins in multidrug resistance. Chin J Cancer (2011) 1.08
Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharm Res (2008) 1.07
MicroRNA-mediated drug resistance in breast cancer. Clin Epigenetics (2011) 1.06
Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci (2010) 1.05
The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol (2000) 1.04
Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia (2010) 1.04
Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis. Biochim Biophys Acta (2013) 1.03
Fanconi's Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient. Gut Liver (2010) 1.02
Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles. J Physiol (2003) 1.02
Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal. Biochem J (2000) 1.00
Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter. Eukaryot Cell (2002) 0.99
Chronopharmacokinetics of drugs in toxicological aspects: A short review for pharmacy practitioners. J Res Pharm Pract (2012) 0.98
Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation. Br J Haematol (2013) 0.96
Modeling kinetics of subcellular disposition of chemicals. Chem Rev (2009) 0.96
Requirement of the N-terminal extension for vacuolar trafficking and transport activity of yeast Ycf1p, an ATP-binding cassette transporter. Mol Biol Cell (2002) 0.93
Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia (2011) 0.93
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proc Natl Acad Sci U S A (2001) 0.93
Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci (2008) 0.92
In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm Res (2006) 0.92
Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis. Am J Pathol (2009) 0.92
Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents. World J Gastroenterol (2008) 0.90
Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Am J Pathol (2003) 0.90
Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). Drug Metab Dispos (2008) 0.90
Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem (2012) 0.90
Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. Antimicrob Agents Chemother (2004) 0.89
Differential Induction of Proteins in Anopheles gambiae sensu stricto (Diptera: Cullicidae) Larvae in Response to Heavy Metal Selection. Int J Trop Insect Sci (2006) 0.86
L-Rhamnose transport is sugar kinase (RhaK) dependent in Rhizobium leguminosarum bv. trifolii. J Bacteriol (2007) 0.86
The impact of farnesoid X receptor activation on intestinal permeability in inflammatory bowel disease. Can J Gastroenterol (2012) 0.86
Excretion of biliary compounds during intrauterine life. World J Gastroenterol (2009) 0.85
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp. Cancer Cell Int (2015) 0.84
Glycyrrhizic acid in the treatment of liver diseases: literature review. Biomed Res Int (2014) 0.84
Associations between ABCC2 polymorphisms and cisplatin disposition and efficacy. Clin Pharmacol Ther (2012) 0.83
Impact of genetic polymorphisms in transmembrane carrier-systems on drug and xenobiotic distribution. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.81
Membrane drug transporters and chemoresistance in human pancreatic carcinoma. Cancers (Basel) (2010) 0.81
Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei. Malar J (2009) 0.81
Glia and methylmercury neurotoxicity. J Toxicol Environ Health A (2012) 0.81
Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity. Toxicol Appl Pharmacol (2007) 0.81
Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression. Am J Physiol Gastrointest Liver Physiol (2007) 0.81
Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor. Drug Metab Dispos (2012) 0.80
A short update on cancer chemoresistance. Wien Med Wochenschr (2014) 0.79
Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicol Sci (2011) 0.79
Rafts as missing link between multidrug resistance and sphingolipid metabolism. J Membr Biol (2005) 0.79
The role of transporters in toxicity and disease. Drug Metab Dispos (2014) 0.79
Polymorphic transporters and platinum pharmacodynamics. Drug Metab Pharmacokinet (2012) 0.78
Advancement of structure-activity relationship of multidrug resistance-associated protein 2 interactions. AAPS J (2009) 0.78
Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. Chin Med (2011) 0.78
Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.77
Identification and expression analysis of ABC genes in Plasmodium yoelii and P. berghei. Parasitol Res (2003) 0.77
Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. Br J Pharmacol (2001) 0.77
The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea. Biomed Res Int (2015) 0.76
Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother (2006) 0.76
Physiologically realistic and validated mathematical liver model reveals [corrected] hepatobiliary transfer rates for Gd-EOB-DTPA using human DCE-MRI data. PLoS One (2014) 0.76
Kinetic Interpretation of the Importance of OATP1B3 and MRP2 in Docetaxel-Induced Hematopoietic Toxicity. CPT Pharmacometrics Syst Pharmacol (2014) 0.76
Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease. J Biochem Mol Toxicol (2016) 0.75
N-glycoprotein surfaceome of human induced pluripotent stem cell derived hepatic endoderm. Proteomics (2016) 0.75
Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. J Biomed Biotechnol (2009) 0.75
Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer. Tissue Eng Part A (2016) 0.75
The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs. Pharmaceuticals (Basel) (2014) 0.75
A structure-activity relationship study of ABCC2 inhibitors. Eur J Pharm Sci (2017) 0.75
Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules. Science (1996) 18.53
Indium phosphide nanowires as building blocks for nanoscale electronic and optoelectronic devices. Nature (2001) 5.09
Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect Immun (1986) 3.42
Logic gates and computation from assembled nanowire building blocks. Science (2001) 3.14
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem (1994) 2.82
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol (1974) 2.76
Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol (1968) 2.47
Highly polarized photoluminescence and photodetection from single indium phosphide nanowires. Science (2001) 2.35
Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system. Gene Ther (1999) 2.34
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol (2000) 2.21
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem (2000) 2.06
Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells. J Bone Miner Res (1994) 1.98
Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation/cell density-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone. Appl Environ Microbiol (1995) 1.94
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A (2001) 1.87
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem (2000) 1.85
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol (1999) 1.84
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology (1997) 1.83
Characterization of a novel RNA regulator of Erwinia carotovora ssp. carotovora that controls production of extracellular enzymes and secondary metabolites. Mol Microbiol (1998) 1.78
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem (2000) 1.76
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res (1994) 1.73
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res (1996) 1.69
Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc Natl Acad Sci U S A (2001) 1.67
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem (1996) 1.66
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development (2000) 1.66
Oral health behavior and metabolic syndrome and its components in adults. J Dent Res (2012) 1.64
GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proc Natl Acad Sci U S A (2000) 1.60
Ascorbic acid-dependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol (1997) 1.58
Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology (1993) 1.58
Thermodynamic properties of the kinesin neck-region docking to the catalytic core. Biophys J (2003) 1.54
Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node. Cardiovasc Res (2000) 1.50
Chemokine receptor (CCR5) expression in human kidneys and in the HIV infected macaque. Kidney Int (1998) 1.50
Localization of fibroblast growth factor-2 (basic FGF) and FGF receptor-1 in adult human kidney. Kidney Int (1999) 1.49
Cryoglobulinemic glomerulonephritis in thymic stromal lymphopoietin transgenic mice. Am J Pathol (2001) 1.45
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J (1997) 1.44
Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther (2013) 1.42
Expression of chemokines and chemokine receptors during human renal transplant rejection. Am J Kidney Dis (2001) 1.42
One novel and two recurrent mutations in the keratin 5 gene identified in Chinese patients with epidermolysis bullosa simplex. Clin Exp Dermatol (2009) 1.40
Early clinical characteristics and pregnancy outcomes of patients with influenza A (H1N1) infection requiring mechanical ventilation during pregnancy. J Obstet Gynaecol (2013) 1.38
Progressive symmetrical erythrokeratoderma: report of two Chinese families and evaluation for mutations in the loricrin, connexin 30.3 and connexin 31 genes. Clin Exp Dermatol (2013) 1.38
Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology (1996) 1.36
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet (1998) 1.36
Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C. Hepatology (2011) 1.35
Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology (1999) 1.33
ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem (1990) 1.32
Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics (2001) 1.30
Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience (2004) 1.30
Enzymic determination of uracil nucleotides in tissues. Anal Biochem (1970) 1.30
ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J (1996) 1.29
Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome-proliferators-activated receptor (PPAR). Eur J Biochem (1996) 1.28
Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular mass. Eur J Biochem (1999) 1.27
Messenger functions of phosphatidic acid. Chem Phys Lipids (1996) 1.27
Identification of a homeodomain binding element in the bone sialoprotein gene promoter that is required for its osteoblast-selective expression. J Biol Chem (2000) 1.26
TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. Lupus (2010) 1.25
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer (2001) 1.23
Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology (2001) 1.22
Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene. Hypertension (1999) 1.22
Studies on the mechanism of galactosamine-1-phosphate and its inhibition of UDP-glucose pyrophosphorylase. Eur J Biochem (1969) 1.22
Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol (1999) 1.21
Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol Chem (1997) 1.21
Mortality risks of oesophageal cancer associated with hot tea, alcohol, tobacco and diet in Japan. J Epidemiol (1998) 1.21
Global regulation in Erwinia species by Erwinia carotovora rsmA, a homologue of Escherichia coli csrA: repression of secondary metabolites, pathogenicity and hypersensitive reaction. Microbiology (1996) 1.20
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology (1999) 1.20
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol (1995) 1.20
Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology (1987) 1.19
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. Eur J Biochem (1994) 1.19
RpoS (sigma-S) controls expression of rsmA, a global regulator of secondary metabolites, harpin, and extracellular proteins in Erwinia carotovora. J Bacteriol (1998) 1.19
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology (2001) 1.18
ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt. J Biol Chem (1991) 1.18
hexA of Erwinia carotovora ssp. carotovora strain Ecc71 negatively regulates production of RpoS and rsmB RNA, a global regulator of extracellular proteins, plant virulence and the quorum-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone. Environ Microbiol (2000) 1.17
Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol (1997) 1.17
Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster. J Clin Invest (1991) 1.17
Refined localization of a punctate palmoplantar keratoderma gene to a 5.06-cM region at 15q22.2-15q22.31. Br J Dermatol (2005) 1.17
Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci (1998) 1.16
Unconventional Josephson effect in hybrid superconductor-topological insulator devices. Phys Rev Lett (2012) 1.15
Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates: the role of endogenous cysteinyl leukotrienes. Int Arch Allergy Appl Immunol (1987) 1.14
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol (2001) 1.14
Molecular characterization and expression of the Erwinia carotovora hrpNEcc gene, which encodes an elicitor of the hypersensitive reaction. Mol Plant Microbe Interact (1997) 1.12
Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes. FEBS Lett (2000) 1.12
Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter. Leukemia (2006) 1.12
Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis. Diabetes Obes Metab (2007) 1.11
Cigarette smoking, alcohol consumption, and screening mammography among women ages 50 and older. Prev Med (1999) 1.11
Reversed-phase liquid chromatographic determination of cryptotanshinone and its active metabolite in pig plasma and urine. J Pharm Biomed Anal (1999) 1.10
Galactosamine induced liver injury. Prog Liver Dis (1972) 1.10
kdgREcc negatively regulates genes for pectinases, cellulase, protease, HarpinEcc, and a global RNA regulator in Erwinia carotovora subsp. carotovora. J Bacteriol (1999) 1.09
The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. J Neurochem (2001) 1.09
Regulation of BMP/Dpp signaling during embryonic development. Cell Mol Life Sci (2000) 1.08
Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis (2006) 1.08
Metabolism and analysis of cysteinyl leukotrienes in the monkey. J Biol Chem (1986) 1.07