PubRank

D Schenk

Author PubWeight™ 79.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000 8.89
2 Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992 7.16
3 A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009 5.94
4 Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999 5.77
5 Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci U S A 1997 4.92
6 Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997 4.10
7 Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 1997 2.91
8 Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 2005 2.79
9 High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 1998 2.77
10 BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet 2001 2.76
11 Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001 2.75
12 Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 1996 2.69
13 The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1995 2.44
14 Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J Biol Chem 1995 1.70
15 Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol 1992 1.61
16 The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol 1989 1.45
17 Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc Natl Acad Sci U S A 1994 1.31
18 Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging. Am J Pathol 1999 1.17
19 A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol 1997 1.08
20 Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo. Biochem Biophys Res Commun 1986 0.97
21 Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J Biol Chem 1996 0.95
22 Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family. Neurosci Lett 1994 0.95
23 Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation. FEBS Lett 1994 0.91
24 Cerebrospinal fluid levels of amyloid precursor protein and amyloid beta-peptide in Alzheimer's disease and major depression - inverse correlation with dementia severity. Eur Neurol 1998 0.90
25 Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42. Ann N Y Acad Sci 2000 0.88
26 Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. Am J Pathol 2001 0.88
27 Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials. J Pharm Sci 2005 0.86
28 Comparison of the antigenicity and tolerance of an influenza aluminium oxide adsorbate vaccine with an aqueous vaccine. Pharmatherapeutica 1982 0.80
29 Alzheimer's disease. A partner for presenilin. Nature 2000 0.80
30 Follow up after middle-ear ventilation tube insertion: what is needed and when? J Laryngol Otol 2007 0.80
31 Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice. Vaccine 2001 0.79
32 Amyloid beta-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation. Neurosci Lett 1995 0.78
33 Parathyroid cyst: medical diagnosis and therapy. South Med J 1982 0.78
34 Recent advances in the understanding of the processing of APP to beta amyloid peptide. Ann N Y Acad Sci 2000 0.77
35 Recombinant expression of a secreted form of the atrial natriuretic peptide clearance receptor. J Biol Chem 1989 0.77
36 [On the question of the synthesis of polycyclic aromatic compounds in bacteria]. Arch Hyg Bakteriol 1968 0.76
37 Effect of the dietary brominated phenol, lanasol, on chemical biotransformation enzymes in the gumboot chiton Cryptochiton stelleri (Middendorf, 1846). Comp Biochem Physiol C Toxicol Pharmacol 2000 0.76
38 [Isolated basaloma of the tympanic membrane in deafness and transitory facial nerve paralysis]. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 1967 0.75
39 [Otologic complications following Kirschner's electrocoagulation of the Gasserian ganglion]. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 1968 0.75
40 [Induction of surfactant formation in the fetal lung using bromhexine metabolite VIII]. Arch Gynakol 1975 0.75
41 [Contribution on Burkitt's sarcoma]. Z Laryngol Rhinol Otol 1967 0.75
42 [Antibodies against A/USSR/90/77 (H1N1) following vaccination with A/New Jersey/76 (Hsw 1 N1)-vaccine]. MMW Munch Med Wochenschr 1978 0.75
43 [Treatment of Candida infections in pregnancy with Miconazol ovules (author's transl)]. Med Klin 1974 0.75
44 Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats. J Neurosci 1995 0.75
45 [Differential diagnostic interesting vestibular findings]. HNO 1966 0.75
46 [Physical and biochemical parameters for differential diagnosis of premature labor]. Arch Gynakol 1975 0.75
47 Comparison of absolute cerebral haemoglobin concentration in neonates measured directly and by the oxygen swing method both based on near infrared spectrophotometry. Adv Exp Med Biol 1998 0.75
48 [Interruption using prostaglandin F2alpha and E2]. Gynakol Rundsch 1974 0.75
49 [Complications in the recovery room]. Anaesthesist 2000 0.75
50 [Orienting instrument for 3-dimensional measurement of dental models]. Fortschr Kieferorthop 1985 0.75
51 [Further observations on a frequent cause for the development of peritonsillar abscesses following tonsillectomy]. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 1966 0.75
52 Evaluating managed care's special telecommunications needs. Healthc Inform 1993 0.75