Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.

A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97

Endovascular treatment for acute ischemic stroke. N Engl J Med (2013) 8.45

Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet (2012) 7.89

Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology (2009) 3.45

Methodology of the Interventional Management of Stroke III Trial. Int J Stroke (2008) 2.88

Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.55

Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke (2013) 2.50

Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology (2008) 2.48

Current status of endovascular stroke treatment. Circulation (2011) 2.42

The safety and efficacy of thrombolysis for strokes after cardiac catheterization. J Am Coll Cardiol (2008) 2.38

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: design, methods, and rationale. Neurocrit Care (2011) 2.23

Standardized prehospital treatment of stroke. Dtsch Arztebl Int (2011) 2.21

Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the National Institute of Neurological Disorders and Stroke tissue-type plasminogen activator trials. Stroke (2014) 2.19

Solitaire FR thrombectomy system: immediate results in 56 consecutive acute ischemic stroke patients. J Neurointerv Surg (2011) 2.14

The Ischemic Stroke Genetics Study (ISGS) Protocol. BMC Neurol (2003) 1.98

Prospective, multicenter, single-arm study of mechanical thrombectomy using Solitaire Flow Restoration in acute ischemic stroke. Stroke (2013) 1.94

Equipoise among recanalization strategies. Neurology (2010) 1.77

Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev (2014) 1.76

Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial. Lancet Neurol (2015) 1.74

Management of thrombolysis-associated symptomatic intracerebral hemorrhage. Arch Neurol (2010) 1.74

The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusion. Stroke (2010) 1.66

Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med (2007) 1.63

Ischaemic stroke in young adults: predictors of outcome and recurrence. J Neurol Neurosurg Psychiatry (2005) 1.58

Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIA. Stroke (2009) 1.56

Treating the acute stroke patient as an emergency: current practices and future opportunities. Int J Clin Pract (2006) 1.55

MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial. Trials (2014) 1.51

Manual aspiration thrombectomy through balloon-tipped guide catheter for rapid clot burden reduction in endovascular therapy for ICA L/T occlusion. Neuroradiology (2012) 1.49

Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke (2009) 1.48

Greater effect of stroke thrombolysis in the presence of arterial obstruction. Ann Neurol (2011) 1.44

Safety and efficacy of mechanical thrombectomy with solitaire stent retrieval for acute ischemic stroke: a systematic review. Neurointervention (2012) 1.29

Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol Disord Drug Targets (2008) 1.24

Alberta Stroke Program early computed tomography score to select patients for endovascular treatment: Interventional Management of Stroke (IMS)-III Trial. Stroke (2013) 1.24

Who will participate in acute stroke trials? Neurology (2009) 1.23

Radiation dose from multidetector row CT imaging for acute stroke. Neuroradiology (2009) 1.22

Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab (2010) 1.19

The MRA-DWI mismatch identifies patients with stroke who are likely to benefit from reperfusion. Stroke (2008) 1.18

Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. J Neurotrauma (2010) 1.17

Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatry (2003) 1.17

Identifying patients at high risk for poor outcome after intra-arterial therapy for acute ischemic stroke. Stroke (2009) 1.15

Ischemic stroke in the elderly: an overview of evidence. Nat Rev Neurol (2010) 1.15

Hemorrhagic transformation of ischemic stroke in diabetics on sulfonylureas. Ann Neurol (2012) 1.14

Imaging-based treatment selection for intravenous and intra-arterial stroke therapies: a comprehensive review. Expert Rev Cardiovasc Ther (2011) 1.14

Evolution of Endovascular Therapy in Acute Stroke: Implications of Device Development. J Stroke (2015) 1.13

Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature. Med Gas Res (2015) 1.12

Neuroprotection in experimental stroke with targeted neurotrophins. NeuroRx (2005) 1.10

Comparative in vitro study of five mechanical embolectomy systems: effectiveness of clot removal and risk of distal embolization. Neuroradiology (2007) 1.09

Endovascular therapy for ischemic stroke. J Clin Neurol (2015) 1.09

Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke. Stroke (2013) 1.07

The Basilar Artery International Cooperation Study (BASICS): study protocol for a randomised controlled trial. Trials (2013) 1.06

Initial experience with a self-expanding retrievable stent for recanalization of large vessel occlusions in acute ischemic stroke. Neuroradiology (2011) 1.05

Intracranial thrombectomy using the Solitaire stent: a historical vignette. J Neurointerv Surg (2011) 1.05

Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase. J Neurol Neurosurg Psychiatry (2007) 1.03

Effectiveness of Thrombolytic Therapy in Acute Embolic Stroke due to Infective Endocarditis. Stroke Res Treat (2009) 1.03

Update on intravenous tissue plasminogen activator for acute stroke: from clinical trials to clinical practice. CMAJ (2001) 1.02

Hemorrhagic transformation: a review of the rate of hemorrhage in the major clinical trials of acute ischemic stroke. Front Neurol (2013) 1.02

Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator. J Neurol Neurosurg Psychiatry (2005) 1.01

Endovascular Recanalization Therapy in Acute Ischemic Stroke: Updated Meta-analysis of Randomized Controlled Trials. J Stroke (2015) 1.01

Mitochondrial targets for stroke: focusing basic science research toward development of clinically translatable therapeutics. Stroke (2009) 1.01

Thrombus burden is associated with clinical outcome after intra-arterial therapy for acute ischemic stroke. Stroke (2008) 1.00

Adjuvant revascularization of intracranial artery occlusion with angioplasty and/or stenting. Neuroradiology (2008) 0.99

Low-pressure balloon angioplasty with adjuvant pharmacological therapy in patients with acute ischemic stroke caused by intracranial arterial occlusions. Neuroradiology (2008) 0.99

Is intra-arterial thrombolysis beneficial for M2 occlusions? Subgroup analysis of the PROACT-II trial. Stroke (2012) 0.99

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence. J Cereb Blood Flow Metab (2011) 0.99

Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag (2009) 0.98

Cost-effectiveness analysis of mechanical thrombectomy in acute ischemic stroke. J Neurosurg (2009) 0.98

Review of stroke thrombolytics. J Stroke (2013) 0.98

Is general anaesthesia preferable to conscious sedation in the treatment of acute ischaemic stroke with intra-arterial mechanical thrombectomy? A review of the literature. Neuroradiology (2012) 0.98

Evolution of endovascular mechanical thrombectomy for acute ischemic stroke. World J Clin Cases (2014) 0.98

Predictive factors of outcome and hemorrhage after acute ischemic stroke treated by mechanical thrombectomy with a stent-retriever. Neuroradiology (2013) 0.97

Ischemic posterior circulation stroke: a review of anatomy, clinical presentations, diagnosis, and current management. Front Neurol (2014) 0.97

Management of ischaemic stroke in the acute setting: review of the current status. Cardiovasc J Afr (2013) 0.97

Penumbra Stroke System as an "add-on" for the treatment of large vessel occlusive disease following thrombolysis: first results. Eur Radiol (2009) 0.96

Thrombolysis with plasmin: implications for stroke treatment. Stroke (2010) 0.96

Tissue-type plasminogen activator as a therapeutic target in stroke. Expert Opin Ther Targets (2008) 0.95

Door-to-puncture: a practical metric for capturing and enhancing system processes associated with endovascular stroke care, preliminary results from the rapid reperfusion registry. J Am Heart Assoc (2014) 0.95

Magnetic resonance imaging in acute ischemic stroke treatment. J Stroke (2014) 0.95

Plasticity of adult sensorimotor system in severe brain infarcts: challenges and opportunities. Neural Plast (2012) 0.94

Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery. Br J Pharmacol (2007) 0.94

Imaging of the ischemic penumbra in acute stroke. Korean J Radiol (2005) 0.94

Machine learning for outcome prediction of acute ischemic stroke post intra-arterial therapy. PLoS One (2014) 0.94

Low awareness of transient ischemic attacks and risk factors of stroke in a Swiss urban community. J Neurol (2007) 0.94

Comparison of susceptibility weighted imaging and TOF-angiography for the detection of Thrombi in acute stroke. PLoS One (2013) 0.93

Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials. Curr Control Trials Cardiovasc Med (2001) 0.93

Imaging in Endovascular Stroke Trials. J Neuroimaging (2015) 0.93

Use of the New Solitaire (TM) AB Device for Mechanical Thrombectomy when Merci Clot Retriever Has Failed to Remove the Clot. A Case Report. Interv Neuroradiol (2009) 0.93

Intra-arterial thrombolysis using double devices: mechanicomechanical or chemicomechanical techniques. J Korean Neurosurg Soc (2012) 0.92

Combined interventional stroke therapy using intracranial stent and local intraarterial thrombolysis (LIT). Neuroradiology (2010) 0.92

Randomized comparison of intra-arterial and intravenous thrombolysis in a canine model of acute basilar artery thrombosis. Neuroradiology (2004) 0.92

Pregnancy and stroke risk in women. Womens Health (Lond Engl) (2011) 0.91

Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes. Stroke (2014) 0.91

Perfusion CT helps decision making for thrombolysis when there is no clear time of onset. J Neurol Neurosurg Psychiatry (2006) 0.91

Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. Interv Neuroradiol (2011) 0.91

Periprocedural arterial spin labeling and dynamic susceptibility contrast perfusion in detection of cerebral blood flow in patients with acute ischemic syndrome. Stroke (2013) 0.91

The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg (2013) 0.90

Anesthesia and Sedation Practices Among Neurointerventionalists during Acute Ischemic Stroke Endovascular Therapy. Front Neurol (2010) 0.90

Thrombolytic Therapy in Acute Ischemic Stroke. Curr Treat Options Cardiovasc Med (2003) 0.90

Impact of acute ischemic stroke treatment in patients >80 years of age: the specialized program of translational research in acute stroke (SPOTRIAS) consortium experience. Stroke (2012) 0.90

2C or not 2C: defining an improved revascularization grading scale and the need for standardization of angiography outcomes in stroke trials. J Neurointerv Surg (2013) 0.90

Revascularization grading in endovascular acute ischemic stroke therapy. Neurology (2012) 0.90

Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke. Neuroradiology (2010) 0.89

The Growth of Certain Bacteria in Media of Different Hydrogen Ion Concentrations. J Bacteriol (1919) 47.74

The Burlington randomized trial of the nurse practitioner. N Engl J Med (1974) 17.02

COLON BACTERIA AND STREPTOCOCCI AND THEIR SIGNIFICANCE IN MILK. Am J Public Health (N Y) (1916) 13.94

The Characteristics of Bacteria of the Colon Type Occurring in Human Feces. J Bacteriol (1918) 8.50

Controversy in counting and attributing events in clinical trials. N Engl J Med (1979) 7.25

Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med (1995) 6.86

Canadian Atrial Fibrillation Anticoagulation (CAFA) Study. J Am Coll Cardiol (1991) 6.55

SOME CONDITIONS AFFECTING THE PRODUCTION OF GELATINASE BY PROTEUS BACTERIA. J Bacteriol (1928) 6.01

A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med (1999) 5.14

Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost (2000) 4.81

A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med (1996) 4.70

PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke (1998) 4.52

A NOTE ON PENFOLD'S MODIFICATION OF BACILLUS COLI COMMUNIS. Science (1913) 4.45

The Burlington randomized trial of the nurse practitioner: health outcomes of patients. Ann Intern Med (1974) 4.37

Urease Activity as Influenced by Oxidation and Reduction. Proc Natl Acad Sci U S A (1933) 4.28

Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation (2000) 4.12

Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med (2003) 3.94

Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs Implantable Defibrillator study. Cardiac Arrest Study Hamburg . Canadian Implantable Defibrillator Study. Eur Heart J (2000) 3.71

A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement. N Engl J Med (1993) 3.67

Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet (1994) 3.51

Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial. Lancet (2000) 3.50

Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol (1992) 3.49

Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science (1984) 3.47

Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators. Lancet (1997) 3.40

Transplantation of cultured human neuronal cells for patients with stroke. Neurology (2000) 3.38

Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases. Lancet (1969) 3.34

Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol (2009) 3.33

Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators. N Engl J Med (2000) 3.32

The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) trial. Neurology (2007) 3.24

Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study. JAMA (2000) 3.17

Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. N Engl J Med (1982) 3.16

Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial. N Engl J Med (1985) 2.99

Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis. N Engl J Med (1979) 2.91

Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group. AJNR Am J Neuroradiol (1993) 2.91

Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke (1999) 2.90

Significance testing to establish equivalence between treatments, with special reference to data in the form of 2X2 tables. Biometrics (1977) 2.87

Global experience in cervical carotid artery stent placement. Catheter Cardiovasc Interv (2000) 2.77

Prognostic importance of myocardial ischemia detected by ambulatory monitoring early after acute myocardial infarction. N Engl J Med (1996) 2.69

Effects of somatostatin on renal function in cirrhosis. Gastroenterology (1992) 2.68

Reversible MRI abnormalities following seizures. Neurology (1995) 2.62

Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med (1998) 2.49

The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope. J Am Coll Cardiol (1999) 2.44

Randomised comparison of two intensities of oral anticoagulant therapy after tissue heart valve replacement. Lancet (1988) 2.44

Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis. J Clin Oncol (2000) 2.35

Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial. Ann Intern Med (1997) 2.28

Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med (1989) 2.28

Selective paralysis of voluntary but not limbically influenced automatic respiration. Arch Neurol (1991) 2.27

Platelet-active drugs : the relationships among dose, effectiveness, and side effects. Chest (2001) 2.25

Spontaneous early improvement following ischemic stroke. Stroke (1995) 2.13

Is Canada falling behind international standards for stroke care? CMAJ (1998) 2.09

How should results from completed studies influence ongoing clinical trials? The CAFA Study experience. Ann Intern Med (1991) 2.06

Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study. Circulation (2000) 2.05

Current global status of carotid artery stent placement. Cathet Cardiovasc Diagn (1998) 1.99

Quality of life in stage II breast cancer: an instrument for clinical trials. J Clin Oncol (1988) 1.93

Circulating levels of endothelin in cirrhosis. Gastroenterology (1993) 1.91

Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement. J Bone Joint Surg Br (2009) 1.91

A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. Ann Oncol (2009) 1.81

Prevention of deep vein thrombosis after elective hip surgery. A randomized trial comparing low molecular weight heparin with standard unfractionated heparin. Ann Intern Med (1991) 1.81

Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue. Psychosom Med (2000) 1.80

Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results. Stroke (2002) 1.80

Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology (1993) 1.79

Prognostic value of arterial pressure, endogenous vasoactive systems, and renal function in cirrhotic patients admitted to the hospital for the treatment of ascites. Gastroenterology (1988) 1.76

Atrial natriuretic factor in cirrhosis with ascites: plasma levels, cardiac release and splanchnic extraction. Hepatology (1988) 1.74

Imaging recommendations for acute stroke and transient ischemic attack patients: A joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery. AJNR Am J Neuroradiol (2013) 1.71

Ardeparin sodium for extended out-of-hospital prophylaxis against venous thromboembolism after total hip or knee replacement. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (2000) 1.71

A Potentiometric Study of Epinephrine. Proc Natl Acad Sci U S A (1931) 1.70

Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS). Circulation (2001) 1.70

Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation (1991) 1.68

Expectorant action of bromhexine in chronic obstructive bronchitis. Br Med J (1970) 1.67

A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. N Engl J Med (1986) 1.67

A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura. J Pediatr (1993) 1.64

Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis. N Engl J Med (1982) 1.64

Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study. Ann Oncol (2010) 1.64

Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo. Am Heart J (2001) 1.62

BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study. J Thromb Haemost (2005) 1.60

Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations. AJNR Am J Neuroradiol (2006) 1.59

Fibrinolytic variables in patients with recurrent venous thrombosis: a prospective cohort study. Thromb Haemost (2001) 1.58

The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization. J Clin Invest (1977) 1.58

Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis. Lancet (1990) 1.56

Dual-chamber versus ventricular pacing. Critical appraisal of current data. Circulation (1996) 1.55

Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trial. Neurology (2001) 1.55

Emergency department use at two Hamilton hospitals. Can Med Assoc J (1975) 1.55

Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement. JAMA (1990) 1.55

Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology (1994) 1.54

Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. The Columbus Investigators. N Engl J Med (1997) 1.54

Intermittent compression units for severe post-phlebitic syndrome: a randomized crossover study. CMAJ (1999) 1.52

Molecular basis of human mitochondrial very-long-chain acyl-CoA dehydrogenase deficiency causing cardiomyopathy and sudden death in childhood. Proc Natl Acad Sci U S A (1995) 1.50

Cyclophosphamide and plasma exchange in multiple sclerosis. Lancet (1991) 1.50

The occurrence of subsequent malignancy in patients presenting with deep vein thrombosis: results from a historical cohort study. Thromb Haemost (1998) 1.49

Rotational vertebral artery occlusion: a mechanism of vertebrobasilar insufficiency. Neurosurgery (1997) 1.47

Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events. Drug Saf (1999) 1.46

Relationship between acute respiratory illness and air pollution levels in an industrial city. Am Rev Respir Dis (1977) 1.46

Use of transcranial Doppler ultrasound to predict outcome in patients with intracranial large-artery occlusive disease. Stroke (2000) 1.46

Coronary patency, infarct size and left ventricular function after thrombolytic therapy for acute myocardial infarction: results from the tissue plasminogen activator: Toronto (TPAT) placebo-controlled trial. TPAT Study Group. J Am Coll Cardiol (1991) 1.45

Mineralocorticoid escape in patients with compensated cirrhosis and portal hypertension. Gastroenterology (1992) 1.45

Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis. Thromb Haemost (1995) 1.44

Approach to blood donors with microcytosis. Transfus Med (2009) 1.41

Improving treatment of chemotherapy-induced neutropenic fever by administration of colony-stimulating factors. J Natl Cancer Inst (1995) 1.40

Poor adherence to placebo or amiodarone therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial. Psychosom Med (1999) 1.40

Impaired response of atrial natriuretic factor to blood volume expansion in acute right ventricular infarction. Am J Cardiol (1991) 1.40