Published in Am J Pathol on December 01, 1999
Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21
Human hepatic stem cells from fetal and postnatal donors. J Exp Med (2007) 4.15
Stem cells and liver regeneration. Gastroenterology (2009) 3.40
The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A (2003) 2.99
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest (2011) 2.83
Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol (2002) 1.88
Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen. Proc Natl Acad Sci U S A (2000) 1.84
The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell (2009) 1.81
Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell (2014) 1.61
Activation of stem cells in hepatic diseases. Cell Tissue Res (2007) 1.59
Liver regeneration: alternative epithelial pathways. Int J Biochem Cell Biol (2009) 1.55
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice. J Clin Invest (2006) 1.54
Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol (2015) 1.45
Aneuploidy as a mechanism for stress-induced liver adaptation. J Clin Invest (2012) 1.23
Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol (2010) 1.11
Recruitment of host progenitor cells in rat liver transplants. Hepatology (2009) 1.09
The role of stem cells in liver repair and fibrosis. Int J Biochem Cell Biol (2009) 1.09
Chromosomal integration of adenoviral vector DNA in vivo. J Virol (2010) 1.07
Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes. Proc Natl Acad Sci U S A (2004) 1.04
Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol (2001) 1.00
Underlying potential: cellular and molecular determinants of adult liver repair. J Clin Invest (2013) 0.98
Size-dependent in vivo growth potential of adult rat hepatocytes. Am J Pathol (2001) 0.97
Liver repopulation for the treatment of metabolic diseases. J Inherit Metab Dis (2001) 0.95
A new technique for primary hepatocyte expansion in vitro. Biotechnol Bioeng (2008) 0.93
Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology (2011) 0.87
Liver repopulation and regeneration: new approaches to old questions. Curr Opin Organ Transplant (2013) 0.85
Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei. Mamm Genome (2013) 0.85
Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens. Dis Model Mech (2008) 0.83
Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression. Am J Pathol (2004) 0.83
Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World J Gastroenterol (2013) 0.82
Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma. PLoS One (2014) 0.81
WNT5A inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration. Am J Pathol (2015) 0.81
Mosaicism in health and disease - clones picking up speed. Nat Rev Genet (2016) 0.79
Hyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway. BMC Gastroenterol (2014) 0.79
Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis. World J Gastroenterol (2003) 0.78
Rodent animal models for surrogate analysis of cell therapy in acute liver failure. Front Physiol (2012) 0.78
Hepatic progenitors for liver disease: current position. Stem Cells Cloning (2010) 0.78
Therapeutic hepatocyte transplant for inherited metabolic disorders: functional considerations, recent outcomes and future prospects. J Inherit Metab Dis (2013) 0.77
Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture. Sci Rep (2017) 0.75
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev (1991) 13.28
Liver regeneration. Science (1997) 12.80
Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet (1994) 4.33
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet (1996) 4.00
Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86
Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med (1998) 3.77
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell (1991) 3.31
Genetics of retroviral integration. Annu Rev Genet (1992) 3.16
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol (1997) 3.15
Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev (1993) 2.95
Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. J Exp Med (1982) 2.77
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet (1995) 2.62
Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol (1998) 2.62
Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron (1997) 2.20
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A (1991) 2.19
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood (1996) 1.99
THE RATE OF INCORPORATION OF LABELED THYMIDINE INTO THE DEOXYRIBONUCLEIC ACID OF REGENERATING RAT LIVER IN RELATION TO THE AMOUNT OF LIVER EXCISED. Cancer Res (1964) 1.68
Recent advances in the isolation of liver cells. Hepatology (1994) 1.63
THE INFLUENCE OF AGE UPON THE INCORPORATION OF THYMIDINE-2-C14 INTO THE DNA OF REGENERATING RAT LIVER. Cancer Res (1964) 1.63
Self-induced correction of the genetic defect in tyrosinemia type I. J Clin Invest (1994) 1.57
SC-0051, a 2-benzoyl-cyclohexane-1,3-dione bleaching herbicide, is a potent inhibitor of the enzyme p-hydroxyphenylpyruvate dioxygenase. FEBS Lett (1993) 1.49
Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol (1997) 1.47
Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell Dev Biol (1987) 1.22
Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology (1997) 1.21
Retroviral-mediated gene transfer of human ornithine transcarbamylase into primary hepatocytes of spf and spf-ash mice. Hum Gene Ther (1992) 1.19
Principles of therapeutic liver repopulation. Semin Liver Dis (1999) 1.17
Expression of heat shock proteins in mouse skin during wound healing. J Histochem Cytochem (1998) 1.05
Lineage analysis using retrovirus vectors. Methods Enzymol (1993) 1.01
Liver stem cells: when the going gets tough they get going. Int J Exp Pathol (1997) 0.93
Localization of cells in the rat brain expressing fumarylacetoacetate hydrolase, the deficient enzyme in hereditary tyrosinemia type 1. Biochim Biophys Acta (1993) 0.93
Aging is associated with reduced liver regeneration and diminished thymidine kinase mRNA content and enzyme activity in the rat. J Lab Clin Med (1991) 0.83
Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I. Hum Gene Ther (1998) 0.83
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell (2001) 8.99
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature (1991) 8.22
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature (1997) 4.82
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet (1996) 4.00
Characterization of a murine gene expressed from the inactive X chromosome. Nature (1991) 3.21
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol (1997) 3.15
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science (2000) 3.07
Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther (1993) 3.02
Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci U S A (1999) 2.97
In vivo gene therapy of hemophilia B: sustained partial correction in factor IX-deficient dogs. Science (1993) 2.95
Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev (1993) 2.95
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet (1995) 2.62
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev (1999) 2.58
DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links. Mol Cell Biol (2000) 2.33
Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol Cell (2001) 2.33
The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol (1994) 2.22
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci U S A (1991) 2.19
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood (1996) 1.99
Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther (1992) 1.92
Transcriptomes of the major human pancreatic cell types. Diabetologia (2011) 1.90
Medical complications in long-term survivors with X-linked myotubular myopathy. J Pediatr (1999) 1.74
Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl Acad Sci U S A (1992) 1.72
In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci U S A (1994) 1.70
Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J Immunol (1999) 1.61
Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor. Circulation (2001) 1.48
The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase. Mol Genet Metab (2001) 1.46
Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p. Nat Genet (1995) 1.43
A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi Jews. Nat Genet (1993) 1.42
Molecular biology of Fanconi anemia: implications for diagnosis and therapy. Blood (1997) 1.35
Microphthalmia with linear skin defects (MLS) syndrome: clinical, cytogenetic, and molecular characterization. Am J Med Genet (1994) 1.35
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Nat Genet (2001) 1.28
Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood (1997) 1.27
Spontaneous deletion in the FMR1 gene in a patient with fragile X syndrome and cherubism. Hum Mol Genet (1995) 1.27
The clinical picture of the Börjeson-Forssman-Lehmann syndrome in males and heterozygous females with PHF6 mutations. Clin Genet (2004) 1.25
Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure. Somat Cell Mol Genet (1996) 1.20
The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. Mol Cell Biol (2000) 1.18
DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function. Blood (1998) 1.16
Prenatal diagnosis of succinic semialdehyde dehydrogenase deficiency: increased accuracy employing DNA, enzyme, and metabolite analyses. Mol Genet Metab (2001) 1.14
Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene (2000) 1.13
Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I. Hum Gene Ther (1997) 1.12
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc Natl Acad Sci U S A (1996) 1.10
Chondrodysplasis punctata: is maternal warfarin therapy a factor? Am J Dis Child (1975) 1.10
Fatal influenza B virus pneumonia in pediatric patients. Pediatr Infect Dis J (1992) 1.09
Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study. J Clin Oncol (1993) 1.07
In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I. Proc Natl Acad Sci U S A (1999) 1.05
Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. Mol Med (1998) 1.03
Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci. Mol Cell Biol (1994) 1.03
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. Osteoarthritis Cartilage (2012) 1.00
Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol (2001) 1.00
In vivo selection of wild-type hematopoietic stem cells in a murine model of Fanconi anemia. Blood (1999) 0.99
Long-term therapy with NTBC and tyrosine-restricted diet in a murine model of hereditary tyrosinemia type I. Mol Genet Metab (2002) 0.99
Fidelity of targeted recombination in human fibroblasts and murine embryonic stem cells. Proc Natl Acad Sci U S A (1991) 0.98
Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor. J Biol Chem (2001) 0.98
A functionally active retrovirus vector for gene therapy in Fanconi anemia group C. Blood (1994) 0.97
Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis. Endocrinology (1996) 0.95
The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice. Mol Endocrinol (1993) 0.94
Point mutations and polymorphisms in the human dystrophin gene identified in genomic DNA sequences amplified by multiplex PCR. Hum Genet (1992) 0.94
Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice. J Cell Physiol (1999) 0.93
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase. J Neurochem (2002) 0.93
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. Gene Ther (2006) 0.92
Phenotypic correction of Fanconi anemia group C knockout mice. Blood (2000) 0.92
Transgenic mouse models for lung cancer. Exp Lung Res (2000) 0.91
Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in Fanconi anemia group C. Mol Ther (2001) 0.91
Congenital trigeminal neuropathy in oculoauriculovertebral dysplasia-hemifacial microsomia (Goldenhar-Gorlin syndrome). J Neurol Neurosurg Psychiatry (1975) 0.91
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase. Genomics (1999) 0.90
Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3. Am J Hum Genet (2000) 0.90
Guide to early diagnosis of biliary obstruction in infancy. Review of 143 cases. Clin Pediatr (Phila) (1985) 0.90
Malignant cardiac myxoma with cerebral metastases. Surg Neurol (1979) 0.89
Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers. J Clin Invest (2001) 0.88
Identification of the mutation in the alkaptonuria mouse model. Mutations in brief no. 216. Online. Hum Mutat (1999) 0.88
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas (1997) 0.87
Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci U S A (1995) 0.87
Chronic lymphocytic thyroiditis: identification of rubella virus antigen in the thyroid of a child with congenital rubella. J Pediatr (1977) 0.87
Hepatic gene therapy: efficient retroviral-mediated gene transfer into rat hepatocytes in vivo. Somat Cell Mol Genet (1993) 0.86
Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice. J Biol Chem (1990) 0.85
The Ashkenazi Jewish Fanconi anemia mutation: incidence among patients and carrier frequency in the at-risk population. Hum Mutat (1994) 0.85
Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents. Cytogenet Genome Res (2009) 0.84
Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase. Cancer Gene Ther (2000) 0.84
Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells. Exp Hematol (2001) 0.84
Chemotherapy can convert unresectable hepatoblastoma. J Pediatr Surg (1992) 0.84
Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I. Hum Gene Ther (1998) 0.83
Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases. Genomics (1995) 0.83
Improving access to intestinal stem cells as a step toward intestinal gene transfer. Hum Gene Ther (1994) 0.82
Therapeutic trials in the murine model of hereditary tyrosinaemia type I: a progress report. J Inherit Metab Dis (1998) 0.81
A comparative study on steroid sulfatase and arylsulfatase C in fibroblast clones from 45,X/47,XXX and 69,XXY. Hum Genet (1984) 0.81