Published in Am J Physiol on December 01, 1999
Muscle Insulin Resistance in Aging (Mirage) | NCT02230839
Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity (MISTY) | NCT03065140
Bioenergetics and Metabolism in Pediatric Populations | NCT03323294
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc (2011) 5.96
PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol Endocrinol Metab (2008) 2.49
The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab (2009) 2.39
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem (2009) 2.28
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest (2005) 2.10
Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab (2006) 2.09
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes (2008) 2.07
Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab (2008) 2.02
Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest (2003) 1.97
Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol (2010) 1.92
Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol (1985) (2008) 1.80
Skeletal muscle fat oxidation: timing and flexibility are everything. J Clin Invest (2005) 1.72
Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71
Novel noninvasive breath test method for screening individuals at risk for diabetes. Diabetes Care (2008) 1.57
Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol (2011) 1.53
Short-term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to beta-adrenergic stimulation. J Physiol (2010) 1.49
Physical inactivity and obesity underlie the insulin resistance of aging. Diabetes Care (2009) 1.49
Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab (2010) 1.45
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J (2008) 1.45
Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate. Diabetes (2008) 1.44
Associations of Low-Intensity Resistance Training with Body Composition and Lipid Profile in Obese Patients with Type 2 Diabetes. PLoS One (2015) 1.44
Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans. J Physiol (2009) 1.41
The role of mitochondria in health and disease. Curr Opin Pharmacol (2009) 1.37
Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. Nutr Metab (Lond) (2004) 1.34
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? Biochim Biophys Acta (2009) 1.34
Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life (2009) 1.33
Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals. J Clin Endocrinol Metab (2009) 1.32
Fat depots, free fatty acids, and dyslipidemia. Nutrients (2013) 1.30
Evidence for physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes. J Biol Chem (2010) 1.29
Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. Metabolism (2008) 1.26
PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. J Lipid Res (2012) 1.23
Intramuscular lipid oxidation and obesity. Am J Physiol Regul Integr Comp Physiol (2008) 1.20
Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes (Lond) (2011) 1.20
Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell (2014) 1.20
Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response. Obesity (Silver Spring) (2009) 1.19
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Mitochondrial deficiency is associated with insulin resistance. Diabetes (2013) 1.15
Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women. J Clin Endocrinol Metab (2006) 1.14
Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol (2012) 1.14
Metabolic signatures of human adipose tissue hypoxia in obesity. Diabetes (2012) 1.10
Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control. Diabetes (2008) 1.10
"Deficiency" of mitochondria in muscle does not cause insulin resistance. Diabetes (2013) 1.09
A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab (2010) 1.09
Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. J Clin Endocrinol Metab (2010) 1.06
Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS One (2010) 1.06
Biological mechanisms that promote weight regain following weight loss in obese humans. Physiol Behav (2013) 1.06
Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes (2010) 1.05
Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes. Diabetes (2011) 1.04
Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation. J Appl Physiol (1985) (2008) 1.04
Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. J Clin Endocrinol Metab (2010) 1.03
Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem (2010) 1.03
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab (2010) 1.03
Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect (2014) 1.02
What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism? Diabetes (2012) 1.02
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. J Clin Invest (2009) 1.01
Mitochondrial energetics and insulin resistance. Endocrinology (2008) 0.99
Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98
Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training. Diabetes (2015) 0.94
Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. Am J Physiol Regul Integr Comp Physiol (2008) 0.93
Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. PLoS One (2013) 0.92
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem (2011) 0.91
Intramyocellular lipid kinetics and insulin resistance. Lipids Health Dis (2007) 0.90
Milk protein for improved metabolic health: a review of the evidence. Nutr Metab (Lond) (2013) 0.89
Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods Enzymol (2009) 0.89
Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome. BMC Genomics (2006) 0.89
Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions. Pharmacol Ther (2008) 0.89
Effect of exercise training on metabolic flexibility in response to a high-fat diet in obese individuals. Am J Physiol Endocrinol Metab (2012) 0.89
Metabolism as a complex genetic trait, a systems biology approach: implications for inborn errors of metabolism and clinical diseases. J Inherit Metab Dis (2008) 0.89
The contribution of race and diabetes status to metabolic flexibility in humans. Metabolism (2010) 0.88
Biomechanical, cardiorespiratory, metabolic and perceived responses to electrically assisted cycling. Eur J Appl Physiol (2012) 0.88
Metabolic switching of human myotubes is improved by n-3 fatty acids. J Lipid Res (2010) 0.88
Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome. Diabetes Care (2013) 0.88
Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy. Mediators Inflamm (2014) 0.87
Carbohydrate intake and glycemic index affect substrate oxidation during a controlled weight cycle in healthy men. Eur J Clin Nutr (2014) 0.87
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. Acta Crystallogr D Biol Crystallogr (2009) 0.87
Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. PLoS One (2010) 0.87
Circadian rhythms, the molecular clock, and skeletal muscle. J Biol Rhythms (2014) 0.87
Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity. J Clin Endocrinol Metab (2014) 0.87
Relation of adipose tissue to metabolic flexibility. Diabetes Res Clin Pract (2008) 0.87
Roles of Fatty Acid oversupply and impaired oxidation in lipid accumulation in tissues of obese rats. J Lipids (2013) 0.86
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. J Physiol (2014) 0.86
Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation. Obesity (Silver Spring) (2011) 0.85
Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes. Am J Physiol Endocrinol Metab (2012) 0.85
Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res (2008) 0.85
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. PLoS One (2012) 0.85
FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria. J Lipid Res (2009) 0.85
Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle. Am J Physiol Endocrinol Metab (2010) 0.85
High fatty acid availability after exercise alters the regulation of muscle lipid metabolism. Metabolism (2010) 0.84
The impact of rapid weight loss on oxidative stress markers and the expression of the metabolic syndrome in obese individuals. J Obes (2013) 0.84
Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. Diabetologia (2006) 0.84
Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. Biochem J (2012) 0.84
A prospective observational study of obesity, body composition, and insulin resistance in 18 women with bipolar disorder and 17 matched control subjects. J Clin Psychiatry (2008) 0.84
Training alters the distribution of perilipin proteins in muscle following acute free fatty acid exposure. J Physiol (2017) 0.84
Using Internet technology to deliver a behavioral weight loss program. JAMA (2001) 8.69
Long-term maintenance of weight loss: current status. Health Psychol (2000) 6.03
A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am J Clin Nutr (1997) 4.96
Ten-year follow-up of behavioral, family-based treatment for obese children. JAMA (1990) 4.54
Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians. Diabetes Care (1990) 4.49
Ten-year outcomes of behavioral family-based treatment for childhood obesity. Health Psychol (1994) 4.42
Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes (1997) 4.15
Menopause and risk factors for coronary heart disease. N Engl J Med (1989) 3.84
Prior to use of estrogen replacement therapy, are users healthier than nonusers? Am J Epidemiol (1996) 3.18
Randomized controlled trial to prevent excessive weight gain in pregnant women. Int J Obes Relat Metab Disord (2002) 2.93
Effects of intermittent exercise and use of home exercise equipment on adherence, weight loss, and fitness in overweight women: a randomized trial. JAMA (1999) 2.93
Strengthening behavioral interventions for weight loss: a randomized trial of food provision and monetary incentives. J Consult Clin Psychol (1993) 2.88
Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest (1993) 2.68
Stress-induced eating. Psychol Bull (1994) 2.57
What predicts weight regain in a group of successful weight losers? . J Consult Clin Psychol (1999) 2.56
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest (1994) 2.51
Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes (1999) 2.48
Are smaller weight losses or more achievable weight loss goals better in the long term for obese patients? J Consult Clin Psychol (1998) 2.41
Educational attainment and behavioral and biologic risk factors for coronary heart disease in middle-aged women. Am J Epidemiol (1989) 2.39
Who reports receiving advice to lose weight? Results from a multistate survey. Arch Intern Med (2000) 2.04
Weight loss treatment influences untreated spouses and the home environment: evidence of a ripple effect. Int J Obes (Lond) (2008) 2.02
Prospective study of the determinants of age at menopause. Am J Epidemiol (1997) 2.02
Dietary and physical activity correlates of long-term weight loss. Obes Res (1994) 2.00
The acute versus the chronic response to exercise. Med Sci Sports Exerc (2001) 1.90
Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int J Obes (Lond) (2006) 1.85
Prescribing exercise in multiple short bouts versus one continuous bout: effects on adherence, cardiorespiratory fitness, and weight loss in overweight women. Int J Obes Relat Metab Disord (1995) 1.83
Are standard behavioral weight loss programs effective for young adults? Int J Obes (Lond) (2009) 1.77
Behavioral strategies of individuals who have maintained long-term weight losses. Obes Res (1999) 1.75
Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest (1995) 1.73
Persons successful at long-term weight loss and maintenance continue to consume a low-energy, low-fat diet. J Am Diet Assoc (1998) 1.72
Persistence of abnormal neural responses to a meal in postobese individuals. Int J Obes Relat Metab Disord (2004) 1.69
The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care (1998) 1.68
Reducing postpartum weight retention through a correspondence intervention. Int J Obes Relat Metab Disord (1998) 1.65
Comparison of obese NIDDM and nondiabetic women: short- and long-term weight loss. Obes Res (1995) 1.60
Aerobic performance in brothers, dizygotic and monozygotic twins. Med Sci Sports Exerc (1986) 1.59
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J Clin Invest (1996) 1.56
Genetics of aerobic and anaerobic performances. Exerc Sport Sci Rev (1992) 1.55
The accuracy of the TriTrac-R3D accelerometer to estimate energy expenditure. Med Sci Sports Exerc (1999) 1.52
Fat content in individual muscle fibers of lean and obese subjects. Int J Obes Relat Metab Disord (2001) 1.52
Weight cycling and cardiovascular risk factors in obese men and women. Am J Clin Nutr (1992) 1.51
Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med (1994) 1.50
Obese binge eaters: affect, cognitions, and response to behavioural weight control. J Consult Clin Psychol (1988) 1.47
Binge antecedents in obese women with and without binge eating disorder. J Consult Clin Psychol (2000) 1.47
The analog free testosterone assay: are the results in men clinically useful? Clin Chem (1998) 1.46
Effects on weight reduction of strong monetary contracts for calorie restriction or weight loss. Behav Res Ther (1978) 1.46
Use of personal trainers and financial incentives to increase exercise in a behavioral weight-loss program. J Consult Clin Psychol (1998) 1.40
Childhood obesity. Pediatr Clin North Am (1985) 1.40
Influences of natural menopause on psychological characteristics and symptoms of middle-aged healthy women. J Consult Clin Psychol (1990) 1.39
Child and parent weight loss in family-based behavior modification programs. J Consult Clin Psychol (1981) 1.38
The prevalence of weight loss maintenance among American adults. Int J Obes Relat Metab Disord (1999) 1.36
Analysis of changes in eating behavior and weight loss in type II diabetic patients. Which behaviors to change. Diabetes Care (1989) 1.34
A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach. Int J Obes (Lond) (2010) 1.34
Physical activity and long-term maintenance of weight loss. Obes Res (1994) 1.33
Accuracy of self-reported exercise and the relationship with weight loss in overweight women. Med Sci Sports Exerc (1998) 1.33
Women's Healthy Lifestyle Project: A randomized clinical trial: results at 54 months. Circulation (2001) 1.33
Weight-loss maintenance in successful weight losers: surgical vs non-surgical methods. Int J Obes (Lond) (2008) 1.32
The effect of weight control on lipid changes in obese children. Am J Dis Child (1989) 1.32
Outpatient treatments of obesity: a comparison of methodology and clinical results. Int J Obes (1979) 1.32
Coronary artery disease in IDDM. Gender differences in risk factors but not risk. Arterioscler Thromb Vasc Biol (1996) 1.31
Effects of diet plus exercise on weight change in parents and children. J Consult Clin Psychol (1984) 1.30
Five-year follow-up of family-based behavioral treatments for childhood obesity. J Consult Clin Psychol (1990) 1.30
Sex differences among participants in a weight-control program. Addict Behav (1994) 1.29
Binge status as a predictor of weight loss treatment outcome. Int J Obes Relat Metab Disord (1999) 1.27
Genetic markers for ancestry are correlated with body composition traits in older African Americans. Osteoporos Int (2007) 1.27
Relationship between changes in food group variety, dietary intake, and weight during obesity treatment. Int J Obes Relat Metab Disord (2004) 1.25
Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obes Rev (2011) 1.24
Skeletal muscle characteristics in sedentary black and Caucasian males. J Appl Physiol (1985) (1986) 1.24
The relationship between presence of exercise equipment in the home and physical activity level. Am J Health Promot (1997) 1.22
Improvement of migraine headaches in severely obese patients after bariatric surgery. Neurology (2011) 1.22
Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism (1994) 1.22
Relationship of a large weight loss to long-term weight change among young and middle-aged US women. Int J Obes Relat Metab Disord (2001) 1.20
Effect of chronic hypoxia on muscle enzyme activities. Int J Sports Med (1990) 1.17
No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol (1985) (2000) 1.15
Responses of maximal aerobic power and capacity to aerobic training. Int J Sports Med (1984) 1.15
Aerobic exercise and weight. Addict Behav (1980) 1.15
Does weight loss maintenance become easier over time? Obes Res (2000) 1.14
Skeletal muscle histochemical and biochemical characteristics in sedentary male and female subjects. Can J Physiol Pharmacol (1985) 1.14
Differences in resting energy expenditure in African-American vs Caucasian overweight females. Int J Obes Relat Metab Disord (1998) 1.13
Does self-monitoring of blood glucose levels improve dietary compliance for obese patients with type II diabetes? Am J Med (1986) 1.12
Accuracy and reliability of the Caltrac accelerometer for estimating energy expenditure. Med Sci Sports Exerc (1990) 1.12
Promoting long-term weight control: does dieting consistency matter? Int J Obes Relat Metab Disord (2004) 1.12
Can physical activity mitigate the effects of aging in middle-aged women? Circulation (1992) 1.11
'Adventure therapy' combined with cognitive-behavioral treatment for overweight adolescents. Int J Obes (Lond) (2006) 1.09
Relapse crises and coping among dieters. J Consult Clin Psychol (1989) 1.09
Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults. Arterioscler Thromb (1993) 1.08
Family-based behavioral weight control in obese young children. J Am Diet Assoc (1986) 1.08
Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients. Diabetes Care (1992) 1.08
Long-term effects of interventions for weight loss using food provision and monetary incentives. J Consult Clin Psychol (1995) 1.08
Long-term effects of family-based treatment of childhood obesity. J Consult Clin Psychol (1987) 1.08
Diet, alcohol, and physical activity as a function of smoking status in middle-aged women. Health Psychol (1993) 1.08
Diagnosis of binge eating disorder: discrepancies between a questionnaire and clinical interview. Int J Eat Disord (1995) 1.07
Psychosocial factors and complications of IDDM. The Pittsburgh Epidemiology of Diabetes Complications Study. VIII. Diabetes Care (1992) 1.06
Use of artificial sweeteners and fat-modified foods in weight loss maintainers and always-normal weight individuals. Int J Obes (Lond) (2009) 1.06
Behavioral treatment of childhood obesity. Psychol Bull (1987) 1.06
Prevention of cardiovascular risk factor elevations in healthy premenopausal women. Prev Med (1995) 1.05
Long-term maintenance of weight loss: do people who lose weight through various weight loss methods use different behaviors to maintain their weight? Int J Obes Relat Metab Disord (1998) 1.05
Reliability and validity of self-report and observers' estimates of relative weight. Addict Behav (1979) 1.04
Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers. J Clin Invest (1995) 1.03
Food intake and physical activity: a comparison of three measures of dieting. Addict Behav (1995) 1.02
Muscle fiber types of women after resistance training--quantitative ultrastructure and enzyme activity. Pflugers Arch (1993) 1.02