| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Pharmacokinetic disposition of quinolones in human body fluids and tissues.
|
Clin Pharmacokinet
|
1989
|
1.67
|
|
2
|
Gastrointestinal secretion of ciprofloxacin. Evaluation of the charcoal model for investigations in healthy volunteers.
|
Am J Med
|
1989
|
1.41
|
|
3
|
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping.
|
Eur J Clin Pharmacol
|
2007
|
1.14
|
|
4
|
Pharmacokinetic/pharmacodynamic modeling of biomarker response to sunitinib in healthy volunteers.
|
Clin Pharmacol Ther
|
2010
|
1.06
|
|
5
|
Continuous or repeated prolonged cisplatin infusions in children: a prospective study on ototoxicity, platinum concentrations, and standard serum parameters.
|
Pediatr Blood Cancer
|
2006
|
0.95
|
|
6
|
Early results from a phase I study on orally administered tris(8-quinolinolato)gallium(III) (FFC11, KP46) in patients with solid tumors--a CESAR study (Central European Society for Anticancer Drug Research--EWIV).
|
Int J Clin Pharmacol Ther
|
2005
|
0.94
|
|
7
|
Oxaliplatin-DNA adduct formation in white blood cells of cancer patients.
|
Br J Cancer
|
2008
|
0.94
|
|
8
|
Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan.
|
Clin Pharmacol Ther
|
2010
|
0.92
|
|
9
|
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
|
Int J Clin Pharmacol Ther
|
2007
|
0.92
|
|
10
|
Feasibility of intraventricular administration of etoposide in patients with metastatic brain tumours.
|
Br J Cancer
|
2001
|
0.89
|
|
11
|
Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration.
|
Am J Med
|
1989
|
0.89
|
|
12
|
Determination of platinum complexes in clinical samples by a rapid flameless atomic absorption spectrometry assay.
|
Ther Drug Monit
|
1999
|
0.86
|
|
13
|
A preliminary report of a Phase II study of folinic acid, 5-fluorouracil, irinotecan (FOLFIRI) plus sunitinib with toxicity, efficacy, pharmacokinetics, biomarker, imaging data in patients with colorectal cancer with liver metastases as 1st line treatment.
|
Int J Clin Pharmacol Ther
|
2011
|
0.83
|
|
14
|
Plasma and tissue pharmacokinetics of epirubicin and Paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer.
|
Clin Pharmacol Ther
|
2007
|
0.83
|
|
15
|
Bioequivalence investigation of high-dose etoposide and etoposide phosphate in lymphoma patients.
|
Cancer Chemother Pharmacol
|
2001
|
0.83
|
|
16
|
Influence of the hOCT2 inhibitor cimetidine on the cellular accumulation and cytotoxicity of oxaliplatin.
|
Int J Clin Pharmacol Ther
|
2009
|
0.82
|
|
17
|
Considerable plasma levels of a cytotoxic etoposide metabolite in patients undergoing high-dose chemotherapy.
|
Eur J Cancer
|
1997
|
0.82
|
|
18
|
In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors.
|
Pharm Res
|
1994
|
0.82
|
|
19
|
Determination of the cytotoxic catechol metabolite of etoposide (3'O-demethyletoposide) in human plasma by high-performance liquid chromatography.
|
J Chromatogr B Biomed Sci Appl
|
1997
|
0.79
|
|
20
|
Assessment of platinum sensitivity in human tumor cells.
|
Int J Clin Pharmacol Ther
|
2003
|
0.79
|
|
21
|
Separation and identification of platinum adducts with DNA nucleotides by capillary zone electrophoresis and capillary zone electrophoresis coupled to mass spectrometry.
|
Electrophoresis
|
2001
|
0.78
|
|
22
|
Potential of on-line isotachophoresis-capillary zone electrophoresis with hydrodynamic counterflow in the analysis of various basic proteins and recombinant human interleukin-3.
|
J Chromatogr A
|
1996
|
0.78
|
|
23
|
Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high-performance size-exclusion chromatography for monitoring of interleukin-6 dimer formation.
|
J Chromatogr A
|
1999
|
0.78
|
|
24
|
Five-day continuous infusion of 5-fluorouracil and pulsed folinic acid in patients with metastatic colorectal carcinoma: an effective second-line regimen.
|
Ann Oncol
|
1997
|
0.78
|
|
25
|
Biomarker response on exposure to sunitinib and its primary metabolite (SU12662) in metastatic colorectal cancer patients.
|
Int J Clin Pharmacol Ther
|
2011
|
0.78
|
|
26
|
Individualised dosing strategy for high-dose carboplatin in patients with germ cell cancer.
|
Br J Cancer
|
2003
|
0.78
|
|
27
|
Defining the role of MRP-mediated efflux and glutathione in detoxification of oxaliplatin.
|
Pharmazie
|
2013
|
0.77
|
|
28
|
Development and application of a simple assay to quantify cellular adducts of platinum complexes with DNA.
|
Pharm Res
|
1999
|
0.77
|
|
29
|
Ultratrace voltammetric determination of DNA-bound platinum in patients after administration of oxaliplatin.
|
Anal Bioanal Chem
|
2004
|
0.77
|
|
30
|
Pharmacokinetic and pharmacodynamic comparison of two doses of calcium folinate combined with continuous fluorouracil infusion in patients with advanced colorectal cancer.
|
Pharm World Sci
|
1999
|
0.76
|
|
31
|
Population pharmacokinetics of cyclophosphamide, doxorubicin and etoposide in 30 patients with BEACOPP chemotherapy.
|
Int J Clin Pharmacol Ther
|
2002
|
0.76
|
|
32
|
Pharmacokinetic study of sodium trans[tetrachlorobis(1H-indazole)-ruthenate (III)]/-indazole hydrochloride (1:1.1) (FFC14A) in patients with solid tumors.
|
Int J Clin Pharmacol Ther
|
2009
|
0.76
|
|
33
|
Targeted doxorubicin-liposomes as a tool to circumvent P-gp-mediated resistance in ovarian carcinoma cells.
|
Int J Clin Pharmacol Ther
|
2010
|
0.75
|
|
34
|
Cerebrospinal fluid pharmacokinetics after different dosage regimens of intraventricular etoposide.
|
Int J Clin Pharmacol Ther
|
2003
|
0.75
|
|
35
|
The 8th annual meeting of CESAR in St. Gallen--novel therapeutic concepts in hemato-oncology.
|
Int J Clin Pharmacol Ther
|
2011
|
0.75
|
|
36
|
Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry.
|
J Chromatogr B Biomed Sci Appl
|
1999
|
0.75
|
|
37
|
[Compliance enhancement in drug therapy : opportunities and limitations].
|
Internist (Berl)
|
2012
|
0.75
|
|
38
|
Reactivity of novel albumin-binding platinum complexes.
|
Int J Clin Pharmacol Ther
|
2004
|
0.75
|
|
39
|
Monitoring of methotrexate and reduced folates in the cerebrospinal fluid of cancer patients.
|
Int J Clin Pharmacol Ther
|
2002
|
0.75
|
|
40
|
[Cyclophosphamide].
|
Dtsch Med Wochenschr
|
2001
|
0.75
|
|
41
|
Monitoring of chemotherapy-induced proteinuria using capillary zone electrophoresis.
|
J Chromatogr B Biomed Sci Appl
|
1999
|
0.75
|
|
42
|
In vitro penetration of des-tyrosine1-D-phenylalanine3-beta-casomorphin across the blood-brain barrier.
|
Peptides
|
1992
|
0.75
|
|
43
|
Interindividual differences in oxaliplatin pharmacokinetics.
|
Int J Clin Pharmacol Ther
|
2002
|
0.75
|
|
44
|
Intracellular ATP depletion leads to reduced platinum accumulation in ovarian cancer cells.
|
Int J Clin Pharmacol Ther
|
2010
|
0.75
|
|
45
|
Population pharmacokinetics of etoposide.
|
Int J Clin Pharmacol Ther
|
2002
|
0.75
|
|
46
|
Quantitative trace analysis of interleukin-3, interleukin-6, and basic model proteins using isotachophoresis-capillary zone electrophoresis with hydrodynamic counterflow.
|
Electrophoresis
|
1998
|
0.75
|
|
47
|
[Fulvestrant].
|
Dtsch Med Wochenschr
|
2006
|
0.75
|
|
48
|
Contribution of glutathione and MRP-mediated efflux to intracellular oxaliplatin accumulation.
|
Int J Clin Pharmacol Ther
|
2010
|
0.75
|
|
49
|
[Bortezomib].
|
Dtsch Med Wochenschr
|
2006
|
0.75
|