PubRank

B R Cullen

Author PubWeight™ 286.57‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 1989 13.92
2 Use of eukaryotic expression technology in the functional analysis of cloned genes. Methods Enzymol 1987 12.66
3 Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 1986 10.71
4 Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 1991 10.53
5 Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function. Cell 1989 7.46
6 Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 1988 6.28
7 Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene 1988 6.13
8 HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. Cell 1990 5.82
9 Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis. Nature 1984 5.26
10 Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events. Proc Natl Acad Sci U S A 1987 4.91
11 HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. Cell 1991 4.61
12 Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes. J Exp Med 1991 4.56
13 Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 1986 4.30
14 Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol Cell Biol 1996 4.10
15 Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. J Virol 1991 3.94
16 Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat. J Virol 1988 3.69
17 Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 1995 3.55
18 Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc Natl Acad Sci U S A 1989 3.43
19 Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. Nature 1988 3.31
20 Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J Exp Med 1993 3.29
21 The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev 1999 3.24
22 Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev 1989 3.09
23 Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat. EMBO J 1998 3.05
24 A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 1987 3.00
25 The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. Mol Cell Biol 1999 2.90
26 Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein. J Virol 1989 2.89
27 HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J 1997 2.86
28 Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol Cell Biol 1993 2.79
29 Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. J Virol 2000 2.72
30 Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products. J Virol 1991 2.62
31 Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. J Cell Sci 1997 2.60
32 Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 1999 2.52
33 The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence. Genes Dev 1992 2.24
34 Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action. Genes Dev 1990 2.24
35 Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J Virol 1998 2.18
36 Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function. J Virol 1993 2.16
37 Characterization of the transcriptional trans activator of human foamy retrovirus. J Virol 1991 2.12
38 Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. Mol Cell Biol 1985 2.12
39 Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein. Proc Natl Acad Sci U S A 1992 1.96
40 Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J Exp Med 1992 1.93
41 Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences. J Virol 1991 1.91
42 Endogenous avian retroviruses contain deficient promoter and leader sequences. Proc Natl Acad Sci U S A 1983 1.90
43 A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses. Nucleic Acids Res 1990 1.90
44 Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species. Proc Natl Acad Sci U S A 1989 1.87
45 Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. Proc Natl Acad Sci U S A 1996 1.87
46 Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. Virology 1995 1.84
47 Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription. Proc Natl Acad Sci U S A 1999 1.82
48 Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. Science 1992 1.76
49 Molecular basis of latency in pathogenic human viruses. Science 1991 1.74
50 Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A 2000 1.67
51 Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. J Virol 1985 1.67
52 The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop. Proc Natl Acad Sci U S A 1998 1.65
53 Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus. J Virol 1993 1.62
54 Phosphorylation of the rev gene product of human immunodeficiency virus type 1. J Virol 1988 1.61
55 Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat. J Virol 1989 1.61
56 An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc Natl Acad Sci U S A 1999 1.59
57 Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module. Mol Cell Biol 1994 1.58
58 Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates. J Virol 2001 1.58
59 Identification of the activation domain of equine infectious anemia virus rev. J Virol 1993 1.57
60 Visna virus encodes a post-transcriptional regulator of viral structural gene expression. Proc Natl Acad Sci U S A 1990 1.55
61 A nuclear role for the Fragile X mental retardation protein. EMBO J 1996 1.54
62 COOH-terminal requirements for the correct processing of a phosphatidylinositol-glycan anchored membrane protein. J Biol Chem 1988 1.52
63 Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Proc Natl Acad Sci U S A 1996 1.52
64 APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export. EMBO Rep 2000 1.50
65 Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. Mol Cell Biol 1986 1.47
66 Effect of intron size on splicing efficiency in retroviral transcripts. Nucleic Acids Res 1982 1.46
67 Expression of active, membrane-bound human placental alkaline phosphatase by transfected simian cells. Proc Natl Acad Sci U S A 1987 1.44
68 In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax. Mol Cell Biol 1994 1.43
69 The complete nucleotide sequence of the Vibrio harveyi bacteriophage VHML. J Appl Microbiol 2002 1.43
70 Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol Cell 2001 1.43
71 The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site. J Virol 1992 1.42
72 Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins. J Virol 1991 1.41
73 Functional analysis of the Tat trans activator of human immunodeficiency virus type 2. J Virol 1989 1.40
74 Determination of the functional domain organization of the importin alpha nuclear import factor. J Cell Biol 1998 1.40
75 Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates. J Virol 1998 1.36
76 Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. Mol Cell Biol 1998 1.35
77 The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function. J Biol Chem 1999 1.28
78 Functional organization of the Bel-1 trans activator of human foamy virus. J Virol 1993 1.27
79 Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation. Mol Cell Biol 1985 1.26
80 Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells. J Virol 1993 1.24
81 Definition of a consensus transportin-specific nucleocytoplasmic transport signal. J Biol Chem 1999 1.22
82 The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein. J Virol 1996 1.22
83 Effect of RNA secondary structure on polyadenylation site selection. Genes Dev 1991 1.21
84 Using viral species specificity to define a critical protein/RNA interaction surface. Genes Dev 2001 1.20
85 Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region. J Virol 1989 1.19
86 Chemokine receptors and human immunodeficiency virus infection. Front Biosci 1998 1.18
87 Sequence requirements for Rev multimerization in vivo. Virology 1994 1.18
88 Derivation of a biologically contained replication system for human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 1992 1.18
89 Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4. J Virol 1997 1.17
90 The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells. J Biol Chem 1994 1.17
91 A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo. Virology 1994 1.17
92 Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4. Virology 1997 1.14
93 The role of avian retroviral LTRs in the regulation of gene expression and viral replication. Adv Virus Res 1985 1.13
94 Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. RNA 1998 1.13
95 Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain? Virology 1990 1.12
96 Structural and functional analysis of the avian leukemia virus constitutive transport element. RNA 1999 1.08
97 Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. Mol Cell Biol 1999 1.07
98 Functional differences between human and bovine immunodeficiency virus Tat transcription factors. J Virol 2000 1.07
99 Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element. J Virol 2000 1.07
100 Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. J Virol 1999 1.06
101 Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element. J Virol 1992 1.04
102 The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region. RNA 2000 1.04
103 Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor. Virology 1999 1.04
104 Synergistic enhancement of both initiation and elongation by acidic transcription activation domains. EMBO J 1996 1.03
105 Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter. J Virol 1998 1.02
106 Expression and function of microRNAs encoded by Kaposi's sarcoma-associated herpesvirus. Cold Spring Harb Symp Quant Biol 2006 1.02
107 Expression of transfected DNA in avian cells can be enhanced in trans by retroviral infection. Mol Cell Biol 1985 0.98
108 Structural and functional analysis of the visna virus Rev-response element. J Virol 1992 0.97
109 Genetic analysis indicates that the human foamy virus Bel-1 protein contains a transcription activation domain of the acidic class. J Virol 1994 0.97
110 Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators. Virology 1995 0.96
111 Thermal denaturation of DNA from bromodeoxyuridine substituted cells. Nucleic Acids Res 1976 0.96
112 Rapid analysis of small nucleic acid samples by gel electrophoresis. Anal Biochem 1981 0.95
113 The R region found in the human foamy virus long terminal repeat is critical for both Gag and Pol protein expression. J Virol 2001 0.93
114 Comparative analysis of Rev function in human immunodeficiency virus types 1 and 2. J Virol 1992 0.93
115 Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1. J Virol 1997 0.93
116 Transcriptional trans activators of human and simian foamy viruses contain a small, highly conserved activation domain. J Virol 1993 0.89
117 Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector. Mol Biol Med 1987 0.89
118 Nucleocytoplasmic shuttling by protein nuclear import factors. Eur J Cell Biol 1998 0.88
119 A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters. Mol Cell Biol 1997 0.87
120 Functional consequences of natural sequence variation in the activation domain of HIV-1 Rev. Virology 1996 0.87
121 Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals. J Virol 1991 0.87
122 Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1. J Virol 1998 0.86
123 HIV-1 Nef protein: An invitation to a kill. Nat Med 1999 0.85
124 Role of chemokine receptors in HIV-1 infection and pathogenesis. Adv Virus Res 1999 0.85
125 A rapid and simple procedure for the preparation of homogeneously labeled DNA probes. Gene 1986 0.83
126 Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. J Virol 2000 0.80
127 Forage-based dairying in a water-limited future: use of models to investigate farming system adaptation in southern Australia. J Dairy Sci 2012 0.79
128 Virology. New trick from an old foe. Nature 1996 0.78
129 Human immunodeficiency virus. Chaperoning a pathogen. Nature 1994 0.78
130 Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides. J Biol Chem 1980 0.77
131 Bromodeoxyuridine induction of deoxycytidine deaminase activity in a hamster cell line. Biochim Biophys Acta 1978 0.77
132 AIDS. The positive effect of the negative factor. Nature 1991 0.77
133 Characterization of human interferon-gamma and human interleukin-2 from recombinant mammalian cell lines and peripheral blood lymphocytes. Lymphokine Cytokine Res 1991 0.76
134 A competitive enzyme-linked immunoassay (ELISA) for the measurement of soluble human interleukin-2 receptors (IL-2R, Tac protein). J Immunol Methods 1988 0.75
135 Protein patterns of early mouse embryos during development. Differentiation 1980 0.75
136 Human immunodeficiency virus type 1 rev protein as a negative trans-regulator. DNA 1989 0.75