Published in Curr Biol on February 16, 2000
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell (2003) 4.94
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature (2000) 4.10
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res (2006) 4.06
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A (2000) 3.21
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells. Mol Cell Biol (2000) 2.57
Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol (2001) 2.30
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A (2001) 1.91
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Mol Cell Biol (2003) 1.84
Ku86 is essential in human somatic cells. Proc Natl Acad Sci U S A (2002) 1.71
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol (2007) 1.65
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic Acids Res (2006) 1.51
Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions. Genetics (2001) 1.38
Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells. Nucleic Acids Res (2001) 1.36
Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses. PLoS Pathog (2009) 1.34
Developmental modulation of nonhomologous end joining in Caenorhabditis elegans. Genetics (2006) 1.33
Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks. Stem Cells Dev (2010) 1.23
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol (2004) 1.20
Histone H1 functions as a stimulatory factor in backup pathways of NHEJ. Nucleic Acids Res (2008) 1.10
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic Acids Res (2011) 1.05
Mutations to Ku reveal differences in human somatic cell lines. DNA Repair (Amst) (2008) 1.01
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res (2012) 1.00
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. PLoS Genet (2009) 0.93
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res (2008) 0.90
Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. Nucleic Acids Res (2002) 0.82
Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. Nucleic Acids Res (2005) 0.82
Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS One (2009) 0.81
The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer. Cancers (Basel) (2017) 0.78
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature (1999) 6.42
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (1997) 5.08
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell (1987) 4.70
Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature (1997) 4.34
V(D)J recombination: a functional definition of the joining signals. Genes Dev (1989) 3.96
The characterization of a mammalian DNA structure-specific endonuclease. EMBO J (1994) 3.85
Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science (1994) 3.47
Regulated gene expression in transfected primary chicken erythrocytes. Proc Natl Acad Sci U S A (1986) 3.17
RAG mutations in human B cell-negative SCID. Science (1996) 3.03
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell (1998) 2.97
Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev (1994) 2.87
Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J Biol Chem (1995) 2.80
Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J (1997) 2.78
Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem (1991) 2.70
V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol Cell Biol (1993) 2.66
IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol (1994) 2.51
Electropore diameters, lifetimes, numbers, and locations in individual erythrocyte ghosts. FEBS Lett (1986) 2.32
A regular pattern of two types of 100-residue motif in the sequence of titin. Nature (1990) 2.29
Retracted Stable RNA/DNA hybrids in the mammalian genome: inducible intermediates in immunoglobulin class switch recombination. Science (2000) 2.17
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res (1996) 2.13
Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway. J Biol Chem (1999) 2.06
CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J (1992) 1.94
RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res (1995) 1.93
Mechanistic constraints on diversity in human V(D)J recombination. Mol Cell Biol (1996) 1.86
Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J Biol Chem (1998) 1.66
Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev (1993) 1.65
A description of the holes in human erythrocyte membrane ghosts. J Biol Chem (1982) 1.60
A role for FEN-1 in nonhomologous DNA end joining: the order of strand annealing and nucleolytic processing events. Proc Natl Acad Sci U S A (1999) 1.59
Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol Cell Biol (1998) 1.51
DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr Biol (1998) 1.51
Antigen receptor gene rearrangement. Curr Opin Immunol (1998) 1.48
Retracted Transcription-dependent R-loop formation at mammalian class switch sequences. EMBO J (2000) 1.48
CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J Immunol (1990) 1.47
Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination. Nature (1993) 1.42
Retraction. Science (2000) 1.42
DNA structural elements required for FEN-1 binding. J Biol Chem (1995) 1.42
DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res (1992) 1.41
Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol (1996) 1.39
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc Natl Acad Sci U S A (1990) 1.39
The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire. Mol Cell Biol (2000) 1.38
The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step. Mol Cell Biol (1998) 1.31
Positive and negative selection events during B lymphopoiesis. Curr Opin Immunol (1995) 1.31
Modulation of DNA binding protein affinity directly affects target site demethylation. Mol Cell Biol (2000) 1.31
Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr Opin Genet Dev (1997) 1.29
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem (1993) 1.29
Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints. J Biol Chem (2001) 1.29
Analysis of the defect in DNA end joining in the murine scid mutation. Mol Cell Biol (1992) 1.28
Transcription, topoisomerases and recombination. Experientia (1994) 1.28
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes. Cell (1990) 1.27
V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol Cell Biol (1993) 1.26
Protein binding protects sites on stable episomes and in the chromosome from de novo methylation. Mol Cell Biol (2001) 1.25
Unequal signal and coding joint formation in human V(D)J recombination. Mol Cell Biol (1993) 1.24
V(D)J recombination on minichromosomes is not affected by transcription. J Biol Chem (1992) 1.23
Re: prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst (1997) 1.23
Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci. J Exp Med (1993) 1.22
Time-resolved resonance Raman spectroscopy of intermediates of bacteriorhodopsin: The bK(590) intermediate. Proc Natl Acad Sci U S A (1979) 1.21
Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination. Mol Cell Biol (1999) 1.19
Dynamics of the holes in human erythrocyte membrane ghosts. J Biol Chem (1982) 1.16
Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol (1994) 1.15
Time-resolved resonance Raman characterization of the bL550 intermediate and the two dark-adapted bRDA/560 forms of bacteriorhodopsin. Biophys J (1979) 1.14
Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res (1990) 1.11
The basis for the mechanistic bias for deletional over inversional V(D)J recombination. Genes Dev (1992) 1.10
Vitrectomy for endogenous Klebsiella pneumoniae endophthalmitis with massive subretinal abscess. Ophthalmic Surg Lasers (1997) 1.08
A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences. Nucleic Acids Res (1997) 1.07
Chromosomal DNA demethylation specified by protein binding. EMBO Rep (2001) 1.07
Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes. Gene (1994) 1.06
B cell development in mice with a defective lambda 5 gene. Eur J Immunol (1993) 1.06
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol Immunol (2000) 1.05
Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat Res (1997) 1.05
Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences. Proc Natl Acad Sci U S A (1995) 1.04
Somatic hypermutation of an immunoglobulin mu heavy chain transgene. J Exp Med (1993) 1.04
No evidence of linkage for chromosome 1q42.2-43 in prostate cancer. Am J Hum Genet (1999) 1.04
Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J Biol Chem (1990) 1.03
A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res (2001) 1.03
Improved gene expression by a U3-based retroviral vector. Biochem Biophys Res Commun (1992) 1.02
Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol (1995) 1.02
Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol Rev (1994) 1.02
cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Genomics (1990) 1.01
Interaction of chlorpromazine with the human erythrocyte membrane. J Biol Chem (1984) 1.01
cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics (1991) 0.99
Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation. Biochem Biophys Res Commun (1998) 0.98
Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. Genomics (1995) 0.98
Psychometric characteristics of the Barthel activities of daily living index in stroke patients. J Formos Med Assoc (2001) 0.98
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Res (1998) 0.97
Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin. Biomaterials (2000) 0.97
Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism. Am J Hum Genet (1991) 0.97
Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1). Am J Hum Genet (1990) 0.96
Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol (1990) 0.95
Studies of V(D)J recombination with extrachromosomal substrates. Curr Top Microbiol Immunol (1988) 0.95
Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics (1991) 0.95
DNA length-dependent cooperative interactions in the binding of Ku to DNA. Biochemistry (2001) 0.93
Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen in posttransfusion hepatitis C: putative serological marker for acute viral infection. Proc Natl Acad Sci U S A (1992) 0.93
Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Am J Hum Genet (1992) 0.93
Effects of buyang huanwu decoction on peripheral nerve regeneration using silicone rubber chambers. Am J Chin Med (2001) 0.93