Published in J Leukoc Biol on December 01, 1999
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) (2008) 3.17
Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science (2014) 2.99
Mycobacterium tuberculosis exploits human interferon γ to stimulate macrophage extracellular trap formation and necrosis. J Infect Dis (2013) 2.27
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS One (2007) 1.77
Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol (2003) 1.58
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A (2004) 1.56
Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol (2010) 1.51
Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int J Radiat Oncol Biol Phys (2007) 1.49
Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol Microbiol (2010) 1.49
Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45
The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Res (2005) 1.42
Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol (2008) 1.30
Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology (2011) 1.26
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol (2005) 1.22
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology (2009) 1.20
Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels. J Physiol (2005) 1.17
Irradiation promotes an m2 macrophage phenotype in tumor hypoxia. Front Oncol (2012) 1.12
Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. Exp Mol Med (2010) 1.09
Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. J Biol Chem (2010) 1.06
Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proc Natl Acad Sci U S A (2014) 0.99
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99
Low-level laser therapy induces the expressions of BMP-2, osteocalcin, and TGF-β1 in hypoxic-cultured human osteoblasts. Lasers Med Sci (2012) 0.97
Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? Apoptosis (2009) 0.95
Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds. Int J Low Extrem Wounds (2009) 0.94
Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer. Carcinogenesis (2014) 0.92
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol (2011) 0.92
Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling. Oncotarget (2014) 0.91
Molecular mechanisms regulating macrophage response to hypoxia. Front Immunol (2011) 0.91
New tricks from an old dog: mitochondrial redox signaling in cellular inflammation. Semin Immunol (2013) 0.91
Differential use of the two high-oxygen-affinity terminal oxidases of Brucella suis for in vitro and intramacrophagic multiplication. Infect Immun (2005) 0.91
Surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation. Int J Mol Sci (2010) 0.91
Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma. PLoS One (2013) 0.89
Hypoxia-mediated mitochondrial stress in RAW264.7 cells induces osteoclast-like TRAP-positive cells. Ann N Y Acad Sci (2007) 0.88
HIF-1α is essential for effective PMN bacterial killing, antimicrobial peptide production and apoptosis in Pseudomonas aeruginosa keratitis. PLoS Pathog (2013) 0.87
Hypoxia and Mucosal Inflammation. Annu Rev Pathol (2016) 0.87
Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol (2016) 0.86
Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line. PLoS One (2013) 0.86
Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques. BMC Cardiovasc Disord (2005) 0.86
Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF. PLoS One (2012) 0.86
Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers (2015) 0.85
Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Free Radic Biol Med (2012) 0.85
S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis. Wound Repair Regen (2009) 0.85
Tumor-associated macrophages are a useful biomarker to predict recurrence after surgical resection of nonfunctional pancreatic neuroendocrine tumors. Ann Surg (2014) 0.84
Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence. Infect Immun (2016) 0.84
Oxygen deprivation and the cellular response to hypoxia in adipocytes - perspectives on white and brown adipose tissues in obesity. Front Endocrinol (Lausanne) (2015) 0.84
Reaction patterns of pulmonary macrophages in protracted asphyxiation. Int J Legal Med (2010) 0.84
Aureolib - a proteome signature library: towards an understanding of staphylococcus aureus pathophysiology. PLoS One (2013) 0.83
Obesity and related consequences to ageing. Age (Dordr) (2016) 0.83
Proton concentrations can be a major contributor to the modification of osteoclast and osteoblast differentiation, working independently of extracellular bicarbonate ions. J Bone Miner Metab (2013) 0.83
Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species. Microb Biotechnol (2016) 0.82
Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation. Front Immunol (2013) 0.82
Diabetic vascular disease and the potential role of macrophage glucose metabolism. Ann Med (2011) 0.82
Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression. J Biol Chem (2015) 0.81
A combination of hypoxia and lipopolysaccharide activates tristetraprolin to destabilize proinflammatory mRNAs such as tumor necrosis factor-alpha. Am J Pathol (2010) 0.81
Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival. Eukaryot Cell (2014) 0.81
Expression of HIF-2alpha/EPAS1 in hepatocellular carcinoma. World J Gastroenterol (2004) 0.81
Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi. Front Microbiol (2012) 0.81
Hypoxia: The Force that Drives Chronic Kidney Disease. Clin Med Res (2016) 0.80
The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells. J Biol Chem (2013) 0.80
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun (2016) 0.80
Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis. PLoS One (2014) 0.80
Tumor macrophage redox and effector mechanisms associated with hypoxia. Free Radic Biol Med (2006) 0.80
Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One (2014) 0.79
Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia. Br J Cancer (2001) 0.79
When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen. Int J Cell Biol (2011) 0.79
Tissue metabolism and the inflammatory bowel diseases. J Mol Med (Berl) (2017) 0.78
Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism. Fertil Steril (2008) 0.78
Differential expression of granulocyte, macrophage, and hypoxia markers during early and late wound healing stages following transplantation of tissue-engineered skin substitutes of human origin. Pediatr Surg Int (2014) 0.77
The virtues of oxygenation: low tissue oxygen adversely affects the killing of Leishmania. J Invest Dermatol (2014) 0.77
Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. PLoS One (2015) 0.77
Effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts in vitro. Exp Ther Med (2013) 0.77
Hypoxic stress, hepatocytes and CACO-2 viability and susceptibility to Shigella flexneri invasion. Rev Inst Med Trop Sao Paulo (2013) 0.77
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases. Mediators Inflamm (2016) 0.77
Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: A Multiscale Computational Biology Approach. Front Cell Infect Microbiol (2016) 0.76
Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection. Biochim Biophys Acta (2017) 0.76
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J Clin Invest (2016) 0.75
Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model. Sci Rep (2016) 0.75
Hypoxia-regulated human periodontal ligament cells via Wnt/β-catenin signaling pathway. Medicine (Baltimore) (2017) 0.75
Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts. BMC Cancer (2013) 0.75
Streptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q. J Biol Chem (2017) 0.75
Targeting hypoxia in inflammatory bowel disease. J Investig Med (2016) 0.75
Molecular and Cellular Mechanisms of Antitumor Immune Response Activation by Dendritic Cells. Acta Naturae (2016) 0.75
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition. Microbes Infect (2016) 0.75
Acute hypoxia decreases E. coli LPS-induced cytokine production and NF-kappaB activation in alveolar macrophages. Respir Physiol Neurobiol (2010) 0.75
Oxygen-Loaded Nanodroplets Effectively Abrogate Hypoxia Dysregulating Effects on Secretion of MMP-9 and TIMP-1 by Human Monocytes. Mediators Inflamm (2015) 0.75
Human activated macrophages and hypoxia: a comprehensive review of the literature. Iran J Basic Med Sci (2014) 0.75
Oxygen ultra-fine bubbles water administration prevents bone loss of glucocorticoid-induced osteoporosis in mice by suppressing osteoclast differentiation. Osteoporos Int (2016) 0.75
Nurse clinics and progressive ambulatory patient care. N Engl J Med (1967) 5.78
Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res (2000) 5.74
Variations in the incidence of surgery. N Engl J Med (1969) 5.73
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci U S A (1997) 5.42
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res (1996) 5.38
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol (2000) 5.21
Continuing medical education--an epidemiologic evaluation. N Engl J Med (1970) 4.68
Longitudinal changes in adiposity associated with pregnancy. The CARDIA Study. Coronary Artery Risk Development in Young Adults Study. JAMA (1994) 4.52
Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet (1990) 4.49
Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet (1987) 4.28
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet (1992) 4.10
The contribution of specialists to the delivery of primary care. N Engl J Med (1979) 4.03
Prevalence and sources of patients' unmet expectations for care. Ann Intern Med (1996) 3.98
Equilibrium properties of a voltage-dependent junctional conductance. J Gen Physiol (1981) 3.91
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood (1998) 3.67
Ownership and uses of human tissue: does the Nuffield bioethics report accord with opinion of surgical inpatients? BMJ (1996) 3.58
Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. Cancer Res (1989) 3.35
Kinetic properties of a voltage-dependent junctional conductance. J Gen Physiol (1981) 3.33
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res (2001) 3.27
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer (2001) 3.10
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer (1996) 3.07
Do physicians preach what they practice? A study of physicians' health habits and counseling practices. JAMA (1984) 3.05
Internists' practices in health promotion and disease prevention. A survey. Ann Intern Med (1991) 3.00
Is obesity a risk factor for progressive radiographic knee osteoarthritis? Arthritis Rheum (2009) 2.92
Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer (2002) 2.82
Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am J Clin Nutr (1999) 2.79
Important elements of outpatient care: a comparison of patients' and physicians' opinions. Ann Intern Med (1996) 2.79
Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet (1985) 2.76
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J Clin Oncol (2001) 2.71
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res (2001) 2.66
Excess gains in weight and waist circumference associated with childbearing: The Coronary Artery Risk Development in Young Adults Study (CARDIA). Int J Obes Relat Metab Disord (2004) 2.65
Gap junctional conductance is a simple and sensitive function of intracellular pH. Science (1981) 2.64
Activities, events and outcomes in ambulatory patient care. N Engl J Med (1969) 2.63
eIF4E expression in tumors: its possible role in progression of malignancies. Int J Biochem Cell Biol (1999) 2.57
Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br J Cancer (1974) 2.54
Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol (1995) 2.52
The impact of a program to enhance the competencies of primary care physicians in caring for patients with AIDS. J Gen Intern Med (1986) 2.52
Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer (1999) 2.47
Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer. Lancet (1985) 2.44
Hepatitis C antibody and chronic liver disease in haemophilia. Lancet (1990) 2.44
The impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study. Int J Obes Relat Metab Disord (2003) 2.43
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res (2001) 2.38
Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. J Biol Chem (1989) 2.35
A randomized trial of A.C.T. (asthma care training) for kids. Pediatrics (1984) 2.30
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. Br J Cancer (1991) 2.29
Audit and necropsy. Lancet (1989) 2.27
Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis. Ann Rheum Dis (2008) 2.27
Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol (2001) 2.26
Vascular endothelial growth factor platelet counts, and prognosis in renal cancer. Lancet (1999) 2.26
Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br J Cancer (1996) 2.23
Chronic hepatitis in United Kingdom blood donors infected with hepatitis C virus. Trent Regional Hepatitis C Virus Study Group. BMJ (1994) 2.22
Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res (1994) 2.21
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br J Cancer (2003) 2.20
Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. Am J Pathol (1997) 2.19
Malignant melanoma: social status and outdoor work. Br J Cancer (1980) 2.18
Influenza in Britain 1967-68. J Hyg (Lond) (1969) 2.18
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol (2000) 2.18
Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Lancet (1987) 2.15
Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo. Angiogenesis (2001) 2.14
Melanomas of the eye and other noncutaneous sites: epidemiologic aspects. J Natl Cancer Inst (1976) 2.11
Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J Pathol (2000) 2.11
Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer. J Clin Pathol (2005) 2.10
Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J Biol Chem (1998) 2.08
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature (1988) 2.07
Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst (1995) 2.07
Intracellular calcium and tension during fatigue in isolated single muscle fibres from Xenopus laevis. J Physiol (1989) 2.05
Cellular mechanisms of fatigue in skeletal muscle. Am J Physiol (1991) 2.03
Secretion of epidermal growth factor by macrophages associated with breast carcinoma. Lancet (1993) 2.03
Acute Myeloid Leukaemia in Adolescents. Br Med J (1961) 2.01
The sexual history-taking and counseling practices of primary care physicians. West J Med (1987) 1.97
Changes in risk factors for cardiovascular disease by baseline weight status in young adults who maintain or gain weight over 15 years: the CARDIA study. Int J Obes (Lond) (2006) 1.96
Lack of independent relationships between left ventricular mass and cardiovascular reactivity to physical and psychological stress in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Hypertens (1996) 1.95
Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study. Gut (2004) 1.93
Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene (2010) 1.93
AIDS-related competence of California's primary care physicians. Am J Public Health (1987) 1.91
A model for predicting the counseling practices of physicians. J Gen Intern Med (1986) 1.91
Voltage dependence of junctional conductance in early amphibian embryos. Science (1979) 1.90
A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res (1994) 1.89
The association between sleep duration and obesity in older adults. Int J Obes (Lond) (2008) 1.89
Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res (1995) 1.84
Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer (1987) 1.83
Clinical necropsy rates during the 1980s: the continued decline. J Pathol (1993) 1.83
Targeting gene expression to hypoxic tumor cells. Nat Med (1997) 1.82
Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol (1995) 1.81
bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer (1994) 1.81
The potential impact of sexual equality on health. N Engl J Med (1977) 1.79
Association between MHC class II alleles and clearance of circulating hepatitis C virus. Members of the Trent Hepatitis C Virus Study Group. J Infect Dis (1998) 1.77
The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br J Cancer (2011) 1.77
Incidence of and mortality from malignant melanoma by anatomical site. J Natl Cancer Inst (1971) 1.76
The natural history of chronic hepatitis C in haemophiliacs. Br J Haematol (1996) 1.76
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene. Br J Cancer (2010) 1.74
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. Nucleic Acids Res (1992) 1.74
A genotype risk score predicts type 2 diabetes from young adulthood: the CARDIA study. Diabetologia (2012) 1.73