Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy.

PubWeight™: 2.57‹?› | Rank: Top 1%

🔗 View Article (PMID 10615904)

Published in Lancet on January 01, 2000

Authors

A J Marian1

Author Affiliations

1: Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. amarian@bcm.tmc.edu

Articles citing this

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest (2007) 4.31

Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation (2001) 3.33

Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation (2001) 3.21

The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov (2008) 2.90

The molecular genetic basis for hypertrophic cardiomyopathy. J Mol Cell Cardiol (2001) 2.83

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2001) 2.23

Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation (2004) 1.72

Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2000) 1.72

The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol (2011) 1.54

Modifier genes for hypertrophic cardiomyopathy. Curr Opin Cardiol (2002) 1.47

Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res (2005) 1.34

Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation. J Am Coll Cardiol (2006) 1.25

Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes. J Am Coll Cardiol (2001) 1.17

Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations. Biophys J (2011) 1.08

Molecular genetics and pathogenesis of hypertrophic cardiomyopathy. Minerva Med (2001) 1.00

How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2010) 0.96

Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes. J Am Heart Assoc (2014) 0.94

ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study). Neth Heart J (2013) 0.94

The genetic landscape of cardiomyopathy and its role in heart failure. Cell Metab (2015) 0.92

Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail (2013) 0.91

Experimental therapies in hypertrophic cardiomyopathy. J Cardiovasc Transl Res (2009) 0.90

Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease. Am J Pathol (2008) 0.87

Subclinical echocardiographic abnormalities in phenotype-negative carriers of myosin-binding protein C3 gene mutation for hypertrophic cardiomyopathy. Am Heart J (2011) 0.86

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation. J Physiol (2014) 0.85

On genetic and phenotypic variability of hypertrophic cardiomyopathy: nature versus nurture. J Am Coll Cardiol (2001) 0.84

Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers. PLoS One (2012) 0.81

Can an energy-deficient heart grow bigger and stronger? J Am Coll Cardiol (2003) 0.80

Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells. Int J Mol Sci (2015) 0.80

To screen or not is not the question--it is when and how to screen. Circulation (2003) 0.79

Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of Single-Gene Disorders. J Am Coll Cardiol (2016) 0.79

Pathophysiology of hypertrophic cardiomyopathy. Lancet (2000) 0.77

The influence of Angiotensin converting enzyme and angiotensinogen gene polymorphisms on hypertrophic cardiomyopathy. PLoS One (2013) 0.76

Myocardial fibrosis in patients with myotonic dystrophy type 1: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson (2014) 0.75

Effect of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy. Heart Int (2006) 0.75

Using baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331P. J Mol Cell Cardiol (2014) 0.75

Association between angiotensinogen M235T polymorphism and hypertrophic cardiomyopathy. Int J Clin Exp Med (2015) 0.75

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs. Nucleus (2017) 0.75

Update on hypertrophic cardiomyopathy. Tex Heart Inst J (2010) 0.75

Emerging pharmacologic and structural therapies for hypertrophic cardiomyopathy. Heart Fail Rev (2017) 0.75