Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMID 10668699)

Published in Neurology on January 25, 2000

Authors

J Limoges1, Y Persidsky, L Poluektova, J Rasmussen, W Ratanasuwan, M Zelivyanskaya, D R McClernon, E R Lanier, H E Gendelman

Author Affiliations

1: Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5215, USA.

Articles by these authors

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol (1986) 37.70

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science (1986) 11.74

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci U S A (1994) 7.85

Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus. J Exp Med (1986) 6.52

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes. Proc Natl Acad Sci U S A (1991) 5.26

Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc Natl Acad Sci U S A (1986) 4.89

Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. Proc Natl Acad Sci U S A (1985) 4.66

Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J Virol (1986) 3.45

Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study. J Virol (1988) 3.40

Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol (1997) 2.92

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. J Virol (1987) 2.84

Selection of a fixative for identifying T cell subsets, B cells, and macrophages in paraffin-embedded mouse spleen. J Immunol Methods (1983) 2.82

Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med (1995) 2.73

Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. Annu Rev Immunol (1990) 2.69

Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants. J Virol (1992) 2.62

HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ (2005) 2.54

Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol (1993) 2.49

Amitriptyline and imipramine poisoning. Lancet (1965) 2.27

Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology (2004) 2.18

A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol (1997) 2.15

Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J Exp Med (1995) 2.11

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci U S A (1996) 2.02

FREQUENCY OF INFECTION IN DONOR EYES POST MORTEM: A METHOD OF OBTAINING STERILE EYES FOR CORNEAL GRAFTING. Br J Ophthalmol (1962) 2.01

Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes. J Immunol (1991) 1.92

Macrophages and the human immunodeficiency virus. Immunol Today (1990) 1.90

Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (1998) 1.90

Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol (1999) 1.86

Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J Immunol (1996) 1.83

Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J Leukoc Biol (2005) 1.77

Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. J Neuroimmunol (1999) 1.76

Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology (2003) 1.70

Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. Proc Natl Acad Sci U S A (1989) 1.61

A double labeling technique for performing immunocytochemistry and in situ hybridization in virus infected cell cultures and tissues. J Virol Methods (1985) 1.60

Activation of the human immunodeficiency virus by herpes simplex virus type 1. J Virol (1987) 1.55

Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol (1996) 1.55

Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J Virol (1994) 1.51

Efficiency of in situ hybridization as a function of probe size and fixation technique. J Virol Methods (1985) 1.47

Organic phosphate poisoning of sheep in Skull Valley, Utah. J Am Vet Med Assoc (1969) 1.46

Toxic epidermal necrolysis. Med Clin North Am (1980) 1.46

Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. J Infect Dis (1998) 1.46

A vesicular intermediate in the transport of hepatoma secretory proteins from the rough endoplasmic reticulum to the Golgi complex. J Cell Biol (1987) 1.44

A comparison of two dosing regimens of zidovudine in Thai adults with early symptomatic HIV infection. Conducting clinical HIV trials in South-East Asia. Aust N Z J Med (2000) 1.42

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders. Prog Polym Sci (2007) 1.41

Persistent expression of Ia antigen and viral genome in visna-maedi virus-induced inflammatory cells. Possible role of lentivirus-induced interferon. J Exp Med (1985) 1.39

Reliability of histo-pathological diagnosis of squamous epithelial changes of the uterine cervix. Acta Pathol Microbiol Scand A (1978) 1.38

Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J Immunol (2000) 1.38

Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. J Virol (1998) 1.38

Slow virus-macrophage interactions. Characterization of a transformed cell line of sheep alveolar macrophages that express a marker for susceptibility to ovine-caprine lentivirus infections. Lab Invest (1984) 1.37

Mental procedures in real-life tasks: a case study of electronic trouble shooting. Ergonomics (1974) 1.37

Macrophages as susceptible targets for HIV infection, persistent viral reservoirs in tissue, and key immunoregulatory cells that control levels of virus replication and extent of disease. AIDS Res Hum Retroviruses (1990) 1.36

The neuropathogenesis of the AIDS dementia complex. AIDS (1997) 1.34

Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence. J Virol (1988) 1.33

Dried-plasma transport using a novel matrix and collection system for human immunodeficiency virus and hepatitis C virus virologic testing. J Clin Microbiol (2009) 1.32

Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia. J Leukoc Biol (2000) 1.32

Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages. J Neuroimmunol (2001) 1.31

Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. J Infect Dis (1999) 1.30

An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. J Neurovirol (1997) 1.28

Interferons in the persistence, pathogenesis, and treatment of HIV infection. AIDS Res Hum Retroviruses (1992) 1.26

Markers of immune activation and viral load in HIV-associated sensory neuropathy. Neurology (2005) 1.25

A model of human immunodeficiency virus encephalitis in scid mice. Proc Natl Acad Sci U S A (1993) 1.25

vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus. J Virol (1996) 1.22

Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia. J Virol (1998) 1.22

The association between depressive symptoms and health status in patients with chronic pulmonary disease. Gen Hosp Psychiatry (2001) 1.20

Genetic characterization of orf viruses isolated from various ruminant species of a zoo. Vet Microbiol (2004) 1.20

Plasma levels of soluble CD14 and tumor necrosis factor-alpha type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection. J Infect Dis (2001) 1.20

"Going solid": a model of system dynamics and consequences for patient safety. Qual Saf Health Care (2005) 1.20

Specific identification of human papillomavirus type in cervical smears and paraffin sections by in situ hybridization with radioactive probes: a preliminary communication. Int J Gynecol Pathol (1985) 1.19

Infection of macrophages with lymphotropic human immunodeficiency virus type 1 can be arrested after viral DNA synthesis. J Virol (1993) 1.19

Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells. Antimicrob Agents Chemother (1994) 1.18

Relative inefficiency of soluble recombinant CD4 for inhibition of infection by monocyte-tropic HIV in monocytes and T cells. J Immunol (1990) 1.18

Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. Placenta (2008) 1.17

The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice. AIDS Res Hum Retroviruses (1989) 1.17

Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report. Neurology (2006) 1.16

Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol Cell Biol (1995) 1.14

Efficient synthesis of viral nucleic acids following monocyte infection by HIV-1. Virology (1995) 1.12

Mononuclear phagocytes as targets, tissue reservoirs, and immunoregulatory cells in human immunodeficiency virus disease. Curr Top Microbiol Immunol (1992) 1.12

Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex. Immunol Today (1995) 1.11

Infection of human gastrointestinal cells by HIV-1. AIDS Res Hum Retroviruses (1990) 1.11

Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J Virol (1999) 1.10

Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120. J Virol (1992) 1.09

Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotox Res (2005) 1.09

[Preventive examinations for cervix cancer in Denmark. Status in 1995. Plans for 1996]. Ugeskr Laeger (1996) 1.07

The neuropathogenesis of HIV-1 infection. FEMS Immunol Med Microbiol (1999) 1.06

The HIV-1 associated dementia complex: a metabolic encephalopathy fueled by viral replication in mononuclear phagocytes. Curr Opin Neurol (1997) 1.05

Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia. J Virol (2001) 1.05

HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. J Neurovirol (2000) 1.04

Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1. J Infect Dis (1999) 1.03

A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J Immunol (1995) 1.02

Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia. J Leukoc Biol (1997) 1.02