Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMID 10690948)

Published in Metabolism on February 01, 2000

Authors

M Manco1, G Mingrone, A V Greco, E Capristo, D Gniuli, A De Gaetano, G Gasbarrini

Author Affiliations

1: Department of Internal Medicine and the Consiglio Nazionale delle Ricerche, Centro Fisiopatologia Shock, Catholic University, Rome, Italy.

Associated clinical trials:

Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity (MISTY) | NCT03065140

Articles citing this

PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest (2007) 2.85

Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res (2008) 2.01

Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity. Am J Physiol Heart Circ Physiol (2009) 1.68

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes (2009) 1.46

Skeletal muscle lipid content and insulin sensitivity in black versus white obese adolescents: is there a race differential? J Clin Endocrinol Metab (2010) 1.30

Palmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells. J Lipid Res (2011) 1.04

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle. PLoS One (2011) 1.01

Imaging body composition in obesity and weight loss: challenges and opportunities. Diabetes Metab Syndr Obes (2010) 0.98

Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. Metabolism (2009) 0.95

Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes. Obesity (Silver Spring) (2010) 0.95

Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle. Diabetologia (2011) 0.93

A clinic-based lifestyle intervention for pediatric obesity: efficacy and behavioral and biochemical predictors of response. J Pediatr Endocrinol Metab (2009) 0.90

Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study. Physiol Res (2012) 0.89

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate. J Lipid Res (2013) 0.85

Investigation of adipose tissues in Zucker rats using in vivo and ex vivo magnetic resonance spectroscopy. J Lipid Res (2010) 0.83

Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. PLoS One (2014) 0.80

Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. Am J Physiol Gastrointest Liver Physiol (2011) 0.80

Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice. PLoS One (2014) 0.79

Effects of polymorphisms in nucleotide-binding oligomerization domains 1 and 2 on biomarkers of the metabolic syndrome and type II diabetes. Genes Nutr (2012) 0.77

Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention. Lipids Health Dis (2009) 0.76

Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate. Comp Biochem Physiol A Mol Integr Physiol (2013) 0.76

Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats. Sci Rep (2016) 0.76

Diet-induced obesity impairs spermatogenesis: a potential role for autophagy. Sci Rep (2017) 0.75

A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD. PLoS Comput Biol (2016) 0.75

Voluntary consumption of ethyl oleate reduces food intake and body weight in rats. Physiol Behav (2007) 0.75

Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults. Endocrinol Metab (Seoul) (2017) 0.75

Articles by these authors

Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study group. Lancet (1999) 5.27

Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest (1997) 3.66

Association of virulent Helicobacter pylori strains with ischemic heart disease. Circulation (1998) 2.75

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology (2005) 2.69

Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference. Aliment Pharmacol Ther (2009) 2.41

The diagnosis of small bowel bacterial overgrowth. Reliability of jejunal culture and inadequacy of breath hydrogen testing. Gastroenterology (1990) 2.32

Endoscopic demonstration of loss of duodenal folds in the diagnosis of celiac disease. N Engl J Med (1988) 2.27

Screening test for coeliac disease. Lancet (1997) 2.23

Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet (1998) 2.15

Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria. Gastroenterology (1993) 2.15

Onset of coeliac disease during treatment with interferon for chronic hepatitis C. Lancet (2000) 2.13

Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Aliment Pharmacol Ther (2011) 2.12

Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients. Cancer (1995) 2.11

Atrophic gastritis as a cause of hyperhomocysteinaemia. Aliment Pharmacol Ther (2004) 2.09

Hydrogen peroxide-related colitis (previously known as "pseudolipomatosis"): a series of cases occurring in an epidemic pattern. Endoscopy (2007) 2.07

Atypical sarcoidosis: case reports and review of the literature. Eur Rev Med Pharmacol Sci (2009) 1.98

Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre. Gut (2005) 1.91

Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther (2003) 1.88

Current European concepts in the management of Helicobacter pylori infection--the Maastricht Consensus Report. The European Helicobacter Pylori Study Group (EHPSG). Eur J Gastroenterol Hepatol (1997) 1.81

Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology (1998) 1.79

Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther (2005) 1.78

Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther (2006) 1.76

Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther (2002) 1.73

Helicobacter pylori reinfection and rapid relapse of low-grade B-cell gastric lymphoma. Lancet (1995) 1.68

Body composition changes induced by chronic ethanol abuse: evaluation by dual energy X-ray absorptiometry. Am J Gastroenterol (2000) 1.63

Oral disodium cromoglycate treatment on irritable bowel syndrome: an open study on 101 subjects with diarrheic type. Am J Gastroenterol (1992) 1.62

Autoimmune enteropathy and villous atrophy in adults. Lancet (1997) 1.62

Beneficial effects of Helicobacter pylori eradication on idiopathic chronic urticaria. Dig Dis Sci (1998) 1.61

Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders. Ital J Gastroenterol Hepatol (1999) 1.60

Levofloxacin-based triple therapy vs. quadruple therapy in second-line Helicobacter pylori treatment: a randomized trial. Aliment Pharmacol Ther (2003) 1.59

Bone mass and metabolism in patients with celiac disease. Gastroenterology (1995) 1.59

Endoscopic markers in adult coeliac disease. Dig Liver Dis (2002) 1.58

Serological screening of coeliac disease: choosing the optimal procedure according to various prevalence values. Gut (1994) 1.57

A highly accurate method for monitoring histological recovery in patients with celiac disease on a gluten-free diet using an endoscopic approach that avoids the need for biopsy: a double-center study. Endoscopy (2007) 1.56

Methodology of the H2 breath test. II. Importance of the test duration in the diagnosis of carbohydrate malabsorption. Ital J Gastroenterol (1990) 1.55

Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther (2005) 1.54

Anticardiolipin antibodies in giant cell arteritis and polymyalgia rheumatica: a study of 40 cases. Br J Rheumatol (1998) 1.54

Howell-Jolly body counting as a measure of splenic function. A reassessment. Clin Lab Haematol (1990) 1.54

The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther (2001) 1.52

Cochlear dysfunction in IDDM patients with subclinical peripheral neuropathy. Diabetes Care (1997) 1.52

Ultrasonography in the diagnosis of portal hypertension: diminished response of portal vessels to respiration. Radiology (1982) 1.52

Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol (1997) 1.52

Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery. Diabetologia (2008) 1.51

Epithelial-cell apoptosis and proliferation in Helicobacter pylori-related chronic gastritis. Ital J Gastroenterol Hepatol (1998) 1.50

Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol (1993) 1.45

Anticholinergic syndrome due to 'Devil's herb': when risks come from the ancient time. Int J Clin Pract (2006) 1.45

A controlled trial of human lymphoblastoid interferon in chronic hepatitis B in Italy. Hepatology (1989) 1.43

Treatment of primary sclerosing cholangitis with low-dose ursodeoxycholic acid: results of a retrospective Italian multicentre survey. Dig Liver Dis (2003) 1.42

Ageing affects anoxia/reoxygenation injury in rat hepatocytes. Scand J Gastroenterol (1998) 1.42

Clinical nutrition practice in Italian Gastroenterology Units. Dig Liver Dis (2001) 1.42

Interferon alpha plus ketoprofen or interferon alpha plus ribavirin in chronic hepatitis C non-responder to interferon alpha alone: results of a pilot study. Ital J Gastroenterol Hepatol (1999) 1.41

Doppler ultrasound evaluation of acute effects of cigarette smoking on portal blood flow in man. J Gastroenterol Hepatol (1996) 1.40

Dicarboxylic acids and glucose utilization in humans: effect of sebacate. JPEN J Parenter Enteral Nutr (1994) 1.40

Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohn's disease. Eur J Gastroenterol Hepatol (2000) 1.39

Effects of Lactobacillus GG on genes expression pattern in small bowel mucosa. Dig Liver Dis (2005) 1.39

Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scand J Gastroenterol (1995) 1.39

Acquired gastric mucosa-associated lymphoid tissue (MALT): a review with special emphasis on association with extragastric diseases and management problems of gastric MALT. J Clin Gastroenterol (1999) 1.38

[Whipple's disease: progress in the diagnosis and review of the literature]. Minerva Med (2002) 1.38

Ability of baclofen in reducing alcohol craving and intake: II--Preliminary clinical evidence. Alcohol Clin Exp Res (2000) 1.38

An 18-year-old woman with familial chylomicronaemia who would not stick to a diet. Lancet (1996) 1.37

Bacteroides thetaiotaomicron in the gut: molecular aspects of their interaction. Dig Liver Dis (2007) 1.36

DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease. Gut (1985) 1.35

Gastrointestinal amyloidosis: a case of chronic diarrhoea. Eur Rev Med Pharmacol Sci (2009) 1.31

Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. Diabetes (1999) 1.31

Quantitative assessment of the mucosal architecture of jejunal biopsy specimens: a comparison between linear measurement, stereology, and computer aided microscopy. J Clin Pathol (1985) 1.30

Anisakis infestation: a case of acute abdomen mimicking Crohn's disease and eosinophilic gastroenteritis. Dig Liver Dis (2005) 1.27

Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. Int J Obes (Lond) (2010) 1.26

Noninvasive antigen-based assay for assessing Helicobacter pylori eradication: a European multicenter study. The European Helicobacter pylori HpSA Study Group. Am J Gastroenterol (2000) 1.26

Prevalence and clinical presentation of subclinical/silent celiac disease in adults: an analysis on a 12-year observation. Hepatogastroenterology (2001) 1.25

Efficacy of two one-week rabeprazole/levofloxacin-based triple therapies for Helicobacter pylori infection. Aliment Pharmacol Ther (2000) 1.24

State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting. Int J Clin Pract (2008) 1.23

Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. J Clin Gastroenterol (1993) 1.20

Liver transplantation: the Italian experience. Dig Liver Dis (2002) 1.19

Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome. Aliment Pharmacol Ther (2005) 1.19

Review article: breath testing for human liver function assessment. Aliment Pharmacol Ther (2002) 1.19

High dosage rifaximin for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther (2007) 1.17

Gluten specific suppressor T cell dysfunction in coeliac disease. Gut (1986) 1.17

Probiotic treatment increases salivary counts of lactobacilli: a double-blind, randomized, controlled study. Digestion (2004) 1.17

Cutaneous manifestations in celiac disease. World J Gastroenterol (2006) 1.16

Helicobacter pylori infection in patients affected by insulin-dependent diabetes mellitus. Eur J Gastroenterol Hepatol (1998) 1.16

A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Aliment Pharmacol Ther (2000) 1.16

Helicobacter pylori eradication helps resolve pyloric and duodenal stenosis. J Clin Gastroenterol (1996) 1.16

Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients. Scand J Gastroenterol (1995) 1.15

Jejunal intraepithelial lymphocytes in coeliac disease: are they increased or decreased? Gut (1984) 1.15

Fatty liver and drugs. Eur Rev Med Pharmacol Sci (2005) 1.15

Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. J Intern Med (1997) 1.15