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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest 2001 2.59
2 Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension. Eur Respir J 2005 1.98
3 Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation 2005 1.84
4 Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 2000 1.80
5 Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation. Blood 2001 1.51
6 Immunomodulation with low-dose immunoglobulins for moderate IgA nephropathy and Henoch-Schönlein purpura. Preliminary results of a prospective uncontrolled trial. Nephron 1995 1.45
7 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br J Pharmacol 2000 1.42
8 Case 4-1993. Inhaled nitric oxide for right ventricular failure after heart transplantation. J Cardiothorac Vasc Anesth 1993 1.39
9 Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 1999 1.37
10 Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J 2001 1.26
11 Decreased VEGF concentration in lung tissue and vascular injury during ARDS. Eur Respir J 2005 1.17
12 Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension. Eur Respir J 2001 1.15
13 Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats. Am J Physiol 1997 1.14
14 Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000 1.13
15 Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am J Respir Cell Mol Biol 2000 1.12
16 Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Eur Respir J 2006 1.11
17 Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Eur Respir J 2009 1.11
18 Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension. Am J Physiol 1998 1.10
19 Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J Clin Invest 1994 1.07
20 High-dose immunoglobulin therapy for severe IgA nephropathy and Henoch-Schönlein purpura. Ann Intern Med 1994 1.02
21 Mechanisms of impaired arterial oxygenation in patients with liver cirrhosis and severe respiratory insufficiency. Effects of indomethacin. Chest 1993 1.02
22 Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer or doxycycline aggravates pulmonary hypertension in rats. Circ Res 2000 1.01
23 Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension. Effect of prostacyclin therapy. Am J Respir Crit Care Med 2000 1.00
24 Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension. Am J Respir Cell Mol Biol 2000 1.00
25 Hemodynamic effects of urapidil in patients with pulmonary hypertension. A comparative study with hydralazine. Am Rev Respir Dis 1987 0.99
26 Pathobiology of pulmonary arterial hypertension. Eur Respir J 2002 0.99
27 Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. Am J Physiol 1995 0.96
28 Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. J Pharmacol Exp Ther 2001 0.95
29 Low molecular weight heparin fractions as an alternative therapy in heparin-induced thrombocytopenia. Haemostasis 1987 0.95
30 Optimal handling of blood samples for routine measurement of lactate and pyruvate. Arch Pathol Lab Med 1994 0.93
31 Haemodynamics and gas exchange before and after coil embolization of pulmonary arteriovenous malformations. Eur Respir J 1995 0.92
32 Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol 2007 0.92
33 Severe hypoxemia-associated intrapulmonary shunt in a patient with chronic liver disease: improvement after medical treatment. Am Rev Respir Dis 1992 0.92
34 Beta-adrenergic contractile reserve as a predictor of clinical outcome in patients with idiopathic dilated cardiomyopathy. Am Heart J 1992 0.92
35 L-arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats. Am J Physiol 1992 0.90
36 Effect of dexfenfluramine treatment in rats exposed to acute and chronic hypoxia. Am J Respir Crit Care Med 1998 0.87
37 Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury. Am J Respir Crit Care Med 1997 0.86
38 Interference of BN 52021, a PAF-acether antagonist, with endotoxin-induced hypotension in the guinea-pig. Pharmacol Res Commun 1986 0.86
39 Renal and vascular effects of C-type and atrial natriuretic peptides in humans. Am J Physiol 1997 0.85
40 Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries. Am J Cardiol 1992 0.85
41 Inhibition of nitric oxide synthesis in the forearm arterial bed of patients with advanced cirrhosis. Hepatology 1995 0.83
42 Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. J Cardiovasc Pharmacol 1993 0.83
43 Cardiac and lung VEGF mRNA expression in chronically hypoxic and monocrotaline-treated rats. Chest 1998 0.83
44 The serotonin pathway in pulmonary hypertension. Arch Mal Coeur Vaiss 2006 0.82
45 Synthesis and secretion of atrial natriuretic factor during chronic hypoxia: a study in the conscious instrumented rat. Clin Sci (Lond) 1990 0.82
46 Myocardial beta-adrenergic desensitization and neuronal norepinephrine uptake function in idiopathic dilated cardiomyopathy. J Cardiovasc Pharmacol 1992 0.82
47 Stimulation of rat platelet adenylate cyclase by an endogenous calcium-dependent protease-like activity. J Cyclic Nucleotide Res 1982 0.82
48 Endothelin dilates bovine pulmonary circulation and reverses hypoxic pulmonary vasoconstriction. J Cardiovasc Pharmacol 1992 0.82
49 Dilator effect of endothelins in pulmonary circulation: changes associated with chronic hypoxia. Am J Physiol 1993 0.82
50 Pulmonary vasodilator responses to atrial natriuretic factor and sodium nitroprusside. J Appl Physiol (1985) 1989 0.80
51 Accuracy of the i-STAT bedside blood gas analyser. Eur Respir J 1999 0.80
52 [Serotonin and pulmonary arterial hypertension]. Rev Mal Respir 2006 0.79
53 Pulmonary vascular response to endothelin in rats. J Appl Physiol (1985) 1991 0.79
54 Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats. J Cardiovasc Pharmacol 1991 0.79
55 Comparison of four demand oxygen delivery systems at rest and during exercise for chronic obstructive pulmonary disease. Respir Med 2004 0.79
56 Pulmonary vasodilatory action of endogenous atrial natriuretic factor in rats with hypoxic pulmonary hypertension. Effects of monoclonal atrial natriuretic factor antibody. Circ Res 1992 0.78
57 Induction of cardiac nitric oxide synthase 2 in rats exposed to chronic hypoxia. J Mol Cell Cardiol 1999 0.78
58 Intravenously administered atrial natriuretic factor in patients with COPD. Effects on ventilation-perfusion relationships and pulmonary hemodynamics. Chest 1994 0.78
59 Forskolin (a powerful inhibitor of human platelet aggregation). Biochem Pharmacol 1982 0.78
60 Renal and hormonal responses to isotonic saline infusion after 3 days' head-down tilt vs. supine and seated positions. Acta Physiol Scand 2003 0.78
61 Polycythemia impairs vasodilator response to acetylcholine in patients with chronic hypoxemic lung disease. Am J Respir Crit Care Med 1998 0.78
62 Hormonal interactions and renal function during mechanical ventilation and ANF infusion in humans. J Appl Physiol (1985) 1991 0.78
63 Cyclic nucleotides in hypertension. Adv Cyclic Nucleotide Res 1980 0.77
64 Sequence dependency of the internalization and distribution of phosphorothioate oligonucleotides in vascular smooth muscle cells. Biochem Pharmacol 1998 0.77
65 Relation between impairment in nitric oxide pathway and clinical status in patients with congestive heart failure. J Cardiovasc Pharmacol 1998 0.77
66 Increased expression of gelatinases and alteration of basement membrane in rat soleus muscle following femoral artery ligation. Neuropathol Appl Neurobiol 2000 0.77
67 Efficacy of cardiopulmonary resuscitation using intratracheal insufflation. Am J Respir Crit Care Med 1996 0.77
68 Short-term efficiency and safety of gene delivery into canine kidneys. Nephrol Dial Transplant 2001 0.77
69 Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. Prostaglandins 1986 0.77
70 Uncoupling by proteolysis of alpha-adrenergic receptor-mediated inhibition of adenylate cyclase in human platelets. Biochem Biophys Res Commun 1982 0.77
71 Improvement of bradykinin endothelium-mediated vasodilation of forearm resistance circulation by quinaprilat in patients with coronary artery disease with or without left ventricular dysfunction. J Cardiovasc Pharmacol 1999 0.77
72 Molsidomine improves flow-dependent vasodilation in brachial arteries of patients with coronary artery disease. J Cardiovasc Pharmacol 2000 0.77
73 Adenovirus-mediated atrial natriuretic protein expression in the lung protects rats from hypoxia-induced pulmonary hypertension. Hum Gene Ther 2001 0.77
74 Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats. Br J Pharmacol 1998 0.77
75 L-arginine improves endothelium-dependent relaxation of conductance and resistance coronary arteries in coronary artery disease. J Cardiovasc Pharmacol 1992 0.77
76 Involvement of ANF in the acute antidiuresis during PEEP ventilation. J Appl Physiol (1985) 1988 0.77
77 Use of glass capillaries avoids the time changes in high blood PO(2) observed with plastic syringes. Chest 2001 0.77
78 Expression of biologically active atrial natriuretic factor following intrahepatic injection of a replication-defective adenoviral vector in dogs. Hum Gene Ther 1999 0.77
79 Changes in the distribution of ventilation and perfusion associated with separation from mechanical ventilation in patients with obstructive pulmonary disease. Anesthesiology 1991 0.76
80 Endothelins and pulmonary hypertension, what directions for the near future? Eur Respir J 2001 0.76
81 Coronary vasodilating action of dobutamine in patients with idiopathic dilated cardiomyopathy. Am Heart J 1993 0.76
82 Measurement of gastric intramucosal pH in patients with cirrhosis and portal hypertensive gastropathy. Gastroenterol Clin Biol 1994 0.76
83 Effects of calcitonin gene-related peptide on cardiac contractility, coronary hemodynamics and myocardial energetics in idiopathic dilated cardiomyopathy. Am J Cardiol 1992 0.75
84 Hypoxia-reoxygenation impairs NO-mediated vasodilation in rat lungs. Am J Physiol 1996 0.75
85 [The adenylate cyclase system of human platelets]. Nouv Rev Fr Hematol 1983 0.75
86 Gene therapy in heart disease. Biomed Pharmacother 2001 0.75
87 Induction of nitric oxide synthase activity in pulmonary arteries from normoxic and chronically hypoxic rats. Eur Respir J 1997 0.75
88 Hemodynamic response to intracoronary infusion of atrial natriuretic factor in patients with normal or altered left ventricular function. J Cardiovasc Pharmacol 1991 0.75
89 Increased erythropoietin synthesis in patients with COLD or left heart failure is related to alterations in renal haemodynamics. Eur J Clin Invest 2001 0.75
90 Cyclic nucleotide phosphodiesterase and aggregation in platelets from diabetic rats. Metabolism 1982 0.75
91 Decreased endothelium-dependent pulmonary vasodilator effect of calcitonin gene-related peptide in hypoxic rats contrasts with increased binding sites. Eur Respir J 1995 0.75
92 Effects of a three-day head-down tilt on renal and hormonal responses to acute volume expansion. Am J Physiol 1999 0.75
93 Adenovirus-mediated transfer of the atrial natriuretic peptide gene in rat pulmonary vascular smooth muscle cells leads to apoptosis. J Lab Clin Med 2001 0.75
94 Effects of ANF infusion on the renal responses to lower-body negative pressure in humans. J Cardiovasc Pharmacol 1998 0.75
95 Intracoronary linsidomine abolishes acetylcholine-induced vasoconstriction of epicardial coronary arteries. J Cardiovasc Pharmacol 1993 0.75
96 Plasmin: a possible physiological modulator of the human platelet adenylate cyclase system. Clin Sci (Lond) 1987 0.75
97 [Vasodilator effects of bradykinin on the resistive circulation of the forearm of coronary patients]. Arch Mal Coeur Vaiss 2000 0.75
98 Local gene delivery within the media of rabbit iliac arteries by using the infiltrator intramural delivery device. J Cardiovasc Pharmacol 1999 0.75
99 [Effects of intracoronary injection of SIN-1 on vasoconstriction of epicardial arteries induced by acetylcholine]. Arch Mal Coeur Vaiss 1993 0.75
100 Haemodynamic effects of urapidil compared to hydralazine in pulmonary hypertension. Eur J Respir Dis Suppl 1986 0.75
101 Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. Agents Actions 1987 0.75