Published in JAMA on February 23, 2000
The limits of psychiatry. BMJ (2002) 4.02
Medical and nonmedical stimulant use among adolescents: from sanctioned to unsanctioned use. CMAJ (2001) 3.18
Biological processes in prevention and intervention: the promotion of self-regulation as a means of preventing school failure. Dev Psychopathol (2008) 2.93
How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis. CMAJ (2001) 2.74
The Preschool Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS) 6-year follow-up. J Am Acad Child Adolesc Psychiatry (2013) 2.48
Psychotropic medication use among Medicaid-enrolled children with autism spectrum disorders. Pediatrics (2008) 2.32
Stimulant medication use in children: a 12-year perspective. Am J Psychiatry (2012) 2.27
Off label prescribing in children. BMJ (2002) 2.15
Mental health services for youths in foster care and disabled youths. Am J Public Health (2001) 2.01
National trends in child and adolescent psychotropic polypharmacy in office-based practice, 1996-2007. J Am Acad Child Adolesc Psychiatry (2010) 1.84
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry (2008) 1.71
Treatment of Attention Deficit/Hyperactivity Disorder among Children with Special Health Care Needs. J Pediatr (2015) 1.46
Evidence and belief in ADHD. BMJ (2000) 1.46
Child/Adolescent anxiety multimodal study: evaluating safety. J Am Acad Child Adolesc Psychiatry (2014) 1.43
The National Children's Study: a critical national investment. Environ Health Perspect (2004) 1.36
A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database. Arch Dis Child (2004) 1.34
Referral gridlock: primary care physicians and mental health services. J Gen Intern Med (2003) 1.26
The relationship between mental health diagnosis and treatment with second-generation antipsychotics over time: a national study of U.S. Medicaid-enrolled children. Health Serv Res (2012) 1.26
Protecting children from environmental toxins. PLoS Med (2005) 1.23
Prescription of methylphenidate to children and youth, 1990-1996. CMAJ (2001) 1.21
Psychotropic drug use in very young children. JAMA (2000) 1.15
Methylphenidate Abuse and Psychiatric Side Effects. Prim Care Companion J Clin Psychiatry (2000) 1.11
An ecological approach to child and family clinical and counseling psychology. Clin Child Fam Psychol Rev (2002) 1.09
Antipsychotic drugs disrupt normal development in Caenorhabditis elegans via additional mechanisms besides dopamine and serotonin receptors. Pharmacol Res (2006) 1.09
Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology (2004) 1.09
A small-scale randomized controlled trial of the revised new forest parenting programme for preschoolers with attention deficit hyperactivity disorder. Eur Child Adolesc Psychiatry (2009) 1.06
Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. Brain Res Bull (2006) 1.04
The impact of impairment criteria on rates of ADHD diagnoses in preschoolers. J Abnorm Child Psychol (2008) 1.02
Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD). Psychopharmacology (Berl) (2008) 1.01
Tracking of medicine use and self-medication from infancy to adolescence: 1993 Pelotas (Brazil) birth cohort study. J Adolesc Health (2012) 1.01
Medicaid managed care and the unmet need for mental health care among children with special health care needs. Health Serv Res (2008) 0.99
Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. J Am Acad Child Adolesc Psychiatry (2008) 0.98
A double-blind, placebo-controlled study of atomoxetine in young children with ADHD. Pediatrics (2011) 0.97
Rise in psychotropic drug prescribing in children and adolescents during 1992-2001: a population-based study in the UK. Eur J Epidemiol (2009) 0.97
Psychopharmacological and other treatments in preschool children with attention-deficit/hyperactivity disorder: current evidence and practice. J Child Adolesc Psychopharmacol (2008) 0.96
A bibliometric study of international scientific productivity in attention-deficit hyperactivity disorder covering the period 1980-2005. Eur Child Adolesc Psychiatry (2008) 0.95
The dopamine dilemma: using stimulants and antipsychotics concurrently. Psychiatry (Edgmont) (2010) 0.95
The ambulatory pediatric association fellowship in pediatric environmental health: a 5-year assessment. Environ Health Perspect (2007) 0.95
The role of family experiences and ADHD in the early development of oppositional defiant disorder. J Consult Clin Psychol (2011) 0.95
Child and adolescent mental health care in Dutch general practice: time trend analyses. BMC Fam Pract (2011) 0.94
Assessing methylphenidate preference in ADHD patients using a choice procedure. Psychopharmacology (Berl) (2004) 0.93
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology (2008) 0.92
Facts, values, and attention-deficit hyperactivity disorder (ADHD): an update on the controversies. Child Adolesc Psychiatry Ment Health (2009) 0.92
Examining subtypes of behavior problems among 3-year-old children, Part I: investigating validity of subtypes and biological risk-factors. J Abnorm Child Psychol (2006) 0.92
State variation in psychotropic medication use by foster care children with autism spectrum disorder. Pediatrics (2009) 0.91
Co-morbidity and patterns of care in stimulant-treated children with ADHD in the Netherlands. Eur Child Adolesc Psychiatry (2009) 0.90
Antipsychotic medication prescribing trends in children and adolescents. J Pediatr Health Care (2012) 0.90
A critique of the international consensus statement on ADHD. Clin Child Fam Psychol Rev (2004) 0.89
Abuse of medications employed for the treatment of ADHD: results from a large-scale community survey. Medscape J Med (2008) 0.89
Profiles of service utilization and the resultant economic impact in preschoolers with attention deficit/hyperactivity disorder. J Pediatr Psychol (2008) 0.89
Parenting Intervention to Reduce Attention and Behavior Difficulties in Preschoolers: A CUIDAR Evaluation Study. J Child Fam Stud (2010) 0.88
National trends in psychotropic medication use in young children: 1994-2009. Pediatrics (2013) 0.88
Is OPTAx useful for monitoring the effect of stimulants on hyperactivity and inattention? A brief report. Eur Child Adolesc Psychiatry (2007) 0.87
The effects of prior authorization policies on medicaid-enrolled children's use of antipsychotic medications: evidence from two mid-Atlantic states. J Child Adolesc Psychopharmacol (2014) 0.87
Pediatric psychopharmacology: too much or too little? World Psychiatry (2013) 0.87
Current issues around the pharmacotherapy of ADHD in children and adults. Pharm World Sci (2009) 0.87
Comparison of delivery strategies for pharmacogenetic testing services. Pharmacogenet Genomics (2014) 0.87
Less discontinuation of ADHD drug use since the availability of long-acting ADHD medication in children, adolescents and adults under the age of 45 years in the Netherlands. Atten Defic Hyperact Disord (2010) 0.86
Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects. J Clin Pharmacol (2010) 0.86
Association between ADHD drug use and injuries among children and adolescents. Eur Child Adolesc Psychiatry (2013) 0.86
From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate. Curr Neuropharmacol (2016) 0.86
Prescribing trends of antipsychotics in youth receiving income assistance: results from a retrospective population database study. BMC Psychiatry (2013) 0.85
Mother's country of birth and prescription of psychotropic medication in Swedish adolescents: a life course approach. BMJ Open (2012) 0.84
The QT interval and psychotropic medications in children: recommendations for clinicians. Eur Child Adolesc Psychiatry (2006) 0.84
Understanding the agreements and controversies surrounding childhood psychopharmacology. Child Adolesc Psychiatry Ment Health (2008) 0.83
Paediatric methylphenidate (Ritalin) restrictive conditions of prescription in France. Br J Clin Pharmacol (2004) 0.83
Psychotropic medications prescribing patterns for children and adolescents in New York's public mental health system. Community Ment Health J (2004) 0.83
Psychotropic drug use among preschool children in the Medicaid program from 36 states. Am J Public Health (2015) 0.83
System struggles and substitutes: A qualitative study of general practitioner and psychiatrist experiences of prescribing antipsychotics to children and adolescents. Clin Child Psychol Psychiatry (2015) 0.83
The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats. Brain Res (2013) 0.83
Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro. J Neural Transm (Vienna) (2006) 0.82
Internalizing disorders in early childhood: a review of depressive and anxiety disorders. Child Adolesc Psychiatr Clin N Am (2009) 0.82
Treatment of anxiety and depression in the preschool period. J Am Acad Child Adolesc Psychiatry (2013) 0.82
The role of pharmacotherapy in the management of self-regulation difficulties in young children. J Can Acad Child Adolesc Psychiatry (2009) 0.82
Sex differences in the behavioral response to methylphenidate in three adolescent rat strains (WKY, SHR, SD). Behav Brain Res (2011) 0.82
Co-segregation of hyperactivity, active coping styles, and cognitive dysfunction in mice selectively bred for low levels of anxiety. Front Behav Neurosci (2013) 0.82
The Subjective Experience of Youth Psychotropic Treatment. Soc Work Ment Health (2004) 0.81
Recent international trends in psychotropic medication prescriptions for children and adolescents. Eur Child Adolesc Psychiatry (2014) 0.80
Environmental enrichment preceding early adulthood methylphenidate treatment leads to long term increase of corticosterone and testosterone in the rat. PLoS One (2011) 0.80
Differences in younger, middle, and older children admitted to child psychiatric inpatient services. Child Psychiatry Hum Dev (2002) 0.80
Substance use disorders in children and adolescents with attention-deficit/hyperactivity disorder: implications for treatment and the role of the primary care physician. Prim Care Companion J Clin Psychiatry (2008) 0.80
Methylphenidate improves performance on the radial arm maze in periadolescent rats. Neurotoxicol Teratol (2008) 0.79
Estimated prevalence of attention-deficit/hyperactivity disorder in a sample of Panamanian school-aged children. Child Psychiatry Hum Dev (2011) 0.79
Preschool parent-pediatrician consultations and predictive referral patterns for problematic behaviors. J Dev Behav Pediatr (2008) 0.78
Risperidone Versus Methylphenidate in Treatment of Preschool Children With Attention-Deficit Hyperactivity Disorder. Iran J Pediatr (2015) 0.78
Forecasting length of stay in child residential treatment. Child Psychiatry Hum Dev (2005) 0.78
Antipsychotic drugs alter neuronal development including ALM neuroblast migration and PLM axonal outgrowth in Caenorhabditis elegans. Int J Dev Neurosci (2008) 0.78
Long-term effects of chronic oral Ritalin administration on cognitive and neural development in adolescent wistar kyoto rats. Brain Sci (2012) 0.78
Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein. Eur J Pharmacol (2007) 0.78
Is methylphenidate effective in reducing symptoms of attention deficit hyperactivity disorder in school-aged children? Paediatr Child Health (2002) 0.78
Acute dose-related differential effects of methylphenidate on murine cystometric parameters. Int Neurourol J (2013) 0.78
No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen (2010) 0.78
Clonidine utilization trends for Medicaid children. Clin Pediatr (Phila) (2012) 0.77
Use of Mental Health Services by Children Ages Six to 11 With Emotional or Behavioral Difficulties. Psychiatr Serv (2015) 0.77
Areas for future investment in the field of ADHD: preschoolers and clinical networks. Eur Child Adolesc Psychiatry (2004) 0.77
Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats. Mol Neurobiol (2016) 0.76
Bipolar disorder in children. Psychiatry J (2014) 0.76
Effects of Stimulants and SSRIs on Brain Function in Children: Emerging Clues from fMRI Studies. Child Adolesc Psychopharmacol News (2011) 0.76
An exploratory study of the combined effects of orally administered methylphenidate and delta-9-tetrahydrocannabinol (THC) on cardiovascular function, subjective effects, and performance in healthy adults. J Subst Abuse Treat (2014) 0.76
Pharmacotherapy of ADHD in young children. Psychiatry (Edgmont) (2006) 0.76
Effect of clinician communication skills training on patient satisfaction. A randomized, controlled trial. Ann Intern Med (1999) 4.10
Tn4351 transposes in Bacteroides spp. and mediates the integration of plasmid R751 into the Bacteroides chromosome. J Bacteriol (1986) 3.90
A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Arch Gen Psychiatry (2001) 3.84
Evidence that the clindamycin-erythromycin resistance gene of Bacteroides plasmid pBF4 is on a transposable element. J Bacteriol (1985) 3.45
Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination. Proc Natl Acad Sci U S A (1979) 2.77
Racial disparity in psychotropic medications prescribed for youths with Medicaid insurance in Maryland. J Am Acad Child Adolesc Psychiatry (1998) 2.30
Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. Lancet (2000) 2.17
Use of randomly cloned DNA fragments for identification of Bacteroides thetaiotaomicron. J Bacteriol (1983) 2.17
Role of Escherichia coli IHF protein in lambda site-specific recombination. A mutational analysis of binding sites. J Mol Biol (1986) 2.13
Mental health services for youths in foster care and disabled youths. Am J Public Health (2001) 2.01
Dissection of an inflammatory process induced by CD8+ T cells. Immunol Today (1990) 1.91
Biocidal activities of glutaraldehyde and related compounds. J Appl Bacteriol (1967) 1.89
Psychotherapeutic medication patterns for youths with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med (1999) 1.87
Developing a culture of lifelong learning in a library environment. Bull Med Libr Assoc (1999) 1.68
Integration and excision of a Bacteroides conjugative transposon, CTnDOT. J Bacteriol (2000) 1.67
Extent of sequence homology required for bacteriophage lambda site-specific recombination. J Mol Biol (1985) 1.62
A comparison of the effects of single-base and triple-base changes in the integrase arm-type binding sites on the site-specific recombination of bacteriophage lambda. Nucleic Acids Res (1990) 1.57
Complementation of bacteriophage lambda integrase mutants: evidence for an intersubunit active site. EMBO J (1993) 1.50
Osteolysis associated with cemented total knee arthroplasty. A case report. J Arthroplasty (1994) 1.48
Mapping the functional domains of bacteriophage lambda integrase protein. J Mol Biol (1994) 1.47
Genetic analysis of bacteriophage lambda integrase interactions with arm-type attachment site sequences. J Bacteriol (1990) 1.45
Identification of genes required for excision of CTnDOT, a Bacteroides conjugative transposon. Mol Microbiol (2001) 1.43
Mutations in an integration host factor-binding site: effect on lambda site-specific recombination and regulatory implications. J Bacteriol (1986) 1.42
Mutational analysis of integrase arm-type binding sites of bacteriophage lambda. Integration and excision involve distinct interactions of integrase with arm-type sites. J Mol Biol (1986) 1.39
Genetic analysis of Escherichia coli integration host factor interactions with its bacteriophage lambda H' recognition site. J Bacteriol (1991) 1.36
Identification and restriction endonuclease mapping of the threonine operon regulatory region. J Mol Biol (1978) 1.35
RsaI: a new sequence-specific endonuclease activity from Rhodopseudomonas sphaeroides. J Bacteriol (1980) 1.34
Use of prostate-specific antigen for prostate cancer screening in primary care practice. Arch Fam Med (1995) 1.34
A genetic enrichment for mutations constructed by oligodeoxynucleotide-directed mutagenesis. Gene (1985) 1.33
Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium ionophore. Cell Immunol (1988) 1.33
Initiation, pausing, and termination of transcription in the threonine operon regulatory region of Escherichia coli. J Biol Chem (1982) 1.31
DNA interactions during bacteriophage lambda site-specific recombination. Cold Spring Harb Symp Quant Biol (1984) 1.30
Characterization of the bacteriophage lambda excisionase (Xis) protein: the C-terminus is required for Xis-integrase cooperativity but not for DNA binding. EMBO J (1992) 1.30
Contributions of RNA secondary structure and length of the thymidine tract to transcription termination at the thr operon attenuator. J Biol Chem (1988) 1.29
Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis. J Exp Med (1987) 1.29
The isolation and characterization of mutants of the integration host factor (IHF) of Escherichia coli with altered, expanded DNA-binding specificities. EMBO J (1992) 1.28
A patient-initiated system for preventive health care. A randomized trial in community-based primary care practices. Arch Fam Med (1998) 1.27
Role of homology in site-specific recombination of bacteriophage lambda: evidence against joining of cohesive ends. Proc Natl Acad Sci U S A (1987) 1.27
Determining the DNA sequence elements required for binding integration host factor to two different target sites. J Bacteriol (1994) 1.25
Phenotypic properties, interleukin 2 production, and developmental origin of a "mature" subpopulation of Lyt-2- L3T4- mouse thymocytes. Proc Natl Acad Sci U S A (1987) 1.24
Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychol Med (2009) 1.23
Direct genetic selection for a specific RNA-protein interaction. Nucleic Acids Res (1993) 1.19
A genetic analysis of Xis and FIS interactions with their binding sites in bacteriophage lambda. J Bacteriol (1991) 1.13
Characterization of a site-specific restriction endonuclease from Rhodopseudomonas sphaeroides. J Bacteriol (1979) 1.13
Intramedullary pressure and pulmonary function during total knee arthroplasty. Clin Orthop Relat Res (1998) 1.11
Drinking patterns, health care utilization, and costs among HMO primary care patients. J Behav Health Serv Res (2001) 1.11
Laparoscopic appendectomy for simple and perforated appendicitis in children: the procedure of choice? J Pediatr Surg (2000) 1.11
Transcription termination by bacteriophage T7 RNA polymerase at rho-independent terminators. J Biol Chem (1990) 1.08
Eight-year outcome associated with clinical options in the management of femoral neck fractures. Clin Orthop Relat Res (1998) 1.07
Methylphenidate patterns among Medicaid youths. Psychopharmacol Bull (1997) 1.06
Growth rebound after termination of stimulant drugs. J Pediatr (1975) 1.06
Operator-promoter functions in the threonine operon of Escherichia coli. J Bacteriol (1975) 1.05
Ly-24 (Pgp-1) expression by thymocytes and peripheral T cells. Immunol Today (1988) 1.05
Patient use of a computer for prevention in primary care practice. Patient Educ Couns (1995) 1.04
Attenuation regulation in the thr operon of Escherichia coli K-12: molecular cloning and transcription of the controlling region. J Bacteriol (1982) 1.04
Improvement in cardiovascular fitness after total knee arthroplasty. J Bone Joint Surg Am (1996) 1.04
Specificity determinants for bacteriophage Hong Kong 022 integrase: analysis of mutants with relaxed core-binding specificities. Mol Microbiol (2000) 1.03
Integration host factor facilitates repression of the put operon in Salmonella typhimurium. Gene (1992) 1.03
Secondary-site attachment of coliphage lambda near the thr operon. J Mol Biol (1974) 1.02
Genetic analysis of the bacteriophage lambda attL nucleoprotein complex. Genetics (1996) 1.01
Defining the structural and functional roles of the carboxyl region of the bacteriophage lambda excisionase (Xis) protein. J Mol Biol (1998) 1.00
The specific binding of Escherichia coli integration host factor involves both major and minor grooves of DNA. Biochemistry (1995) 1.00
Examining the contribution of a dA+dT element to the conformation of Escherichia coli integration host factor-DNA complexes. Nucleic Acids Res (1996) 0.99
The effect of attachment site mutations on strand exchange in bacteriophage lambda site-specific recombination. Genetics (1989) 0.99
"A familial factor in minimal brain dysfunction. Behav Genet (1973) 0.98
Health services use in eating disorders. Psychol Med (2007) 0.97
Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children. Pediatrics (1973) 0.97
Effect of center- versus patient-specific factors on variations in dialysis adequacy. J Am Soc Nephrol (2001) 0.97
Prevalence variations in psychotropic treatment of children. J Child Adolesc Psychopharmacol (1998) 0.95
Practical methods to increase use of advance medical directives. J Gen Intern Med (1999) 0.94
Sutures and disasters in tonsillectomy. Arch Otolaryngol (1968) 0.93
Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered specificity and enhanced affinity. J Biol Chem (1999) 0.93
Duration of hydralazine action in hypertension. Clin Pharmacol Ther (1975) 0.93
Management of tracheal atresia with tracheoesophageal fistula. Anesthesiology (1980) 0.93
The central effects of scopolamine in man. Biol Psychiatry (1971) 0.92
Stroke location is not associated with return to work after first ischemic stroke. Stroke (1999) 0.92
Identification and characterization of mutants affecting transcription termination at the threonine operon attenuator. J Mol Biol (1985) 0.91
Separation of the polyethylene liner from acetabular cup metal backing. A report of three cases. Clin Orthop Relat Res (1992) 0.91
Transcription termination in vitro by bacteriophage T7 RNA polymerase. The role of sequence elements within and surrounding a rho-independent transcription terminator. J Biol Chem (1992) 0.91
Secondary lambda attachment site in the threonine operon attenuator of Escherichia coli. J Bacteriol (1981) 0.90
Reconstruction of the peroneal retinaculum using the peroneus quartus. A case report. J Bone Joint Surg Am (1987) 0.90
Cervical cancer outcomes analysis: impact of age, race, and comorbid illness on hospitalizations for invasive carcinoma of the cervix. Gynecol Oncol (2000) 0.89
Services and prevention: pharmacoepidemiology of antidepressant use. Biol Psychiatry (2001) 0.89
Distraction osteogenesis. A comparison of corticotomy techniques. Clin Orthop Relat Res (1994) 0.88
Mutational analysis of protein binding sites involved in formation of the bacteriophage lambda attL complex. J Bacteriol (1997) 0.88
A motivational environment for behaviorally deviant junior high school students. J Abnorm Child Psychol (1976) 0.88
Expression of Pgp-1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes. Eur J Immunol (1987) 0.86
Characterization of bacteriophage lambda excisionase mutants defective in DNA binding. J Bacteriol (2000) 0.86
Specificity and kinetics defining the interaction between a murine monoclonal autoantibody and DNA. J Biol Chem (1984) 0.86
Fatal massive adrenal hemorrhage after bilateral total knee arthroplasty. J Arthroplasty (1994) 0.86
Specificity of the attenuation response of the threonine operon of Escherichia coli is determined by the threonine and isoleucine codons in the leader transcript. J Mol Biol (1987) 0.86
Source of Pseudomonas aeruginosa infection in premature infants. J Hyg (Lond) (1966) 0.85
Mutants of Escherichia coli integration host factor: DNA-binding and recombination properties. Biochimie (1994) 0.84
Fetal hydrops associated with extralobar pulmonary sequestration. J Ultrasound Med (1986) 0.84
Intramuscular injections and gas gangrene. Br Med J (1968) 0.84
Pulmonary function during and after total hip replacement. Findings in patients who have insertion of a femoral component with and without cement. J Bone Joint Surg Am (1993) 0.84