Published in Clin Chem on March 01, 2000
Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol (2011) 2.09
Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care (2006) 1.78
Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis. J Neurol Sci (2010) 1.59
Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood (2013) 1.56
Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer. Cancer Res (2014) 1.19
Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Crit Care (2012) 1.18
Quantitation of circulating DNA in the serum of breast cancer patients by real-time PCR. Br J Cancer (2004) 1.15
Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room. J Transl Med (2012) 1.12
Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C. J Trauma Acute Care Surg (2012) 1.07
DNA methylation as clinically useful biomarkers-light at the end of the tunnel. Pharmaceuticals (Basel) (2012) 0.99
Plasma levels of mitochondrial and nuclear DNA in patients with massive pulmonary embolism in the emergency department: a prospective cohort study. Crit Care (2013) 0.98
Plasma cell-free DNA in patients needing mechanical ventilation. Crit Care (2011) 0.96
Serum-based DNA methylation biomarkers in colorectal cancer: potential for screening and early detection. J Cancer (2013) 0.93
Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection. PLoS One (2011) 0.92
Effects of extracellular DNA on plasminogen activation and fibrinolysis. J Biol Chem (2011) 0.92
Circulating nucleic acids in plasma and serum (CNAPS): applications in oncology. Onco Targets Ther (2013) 0.92
Elevated levels of circulating DNA in cardiovascular disease patients: metagenomic profiling of microbiome in the circulation. PLoS One (2014) 0.91
Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis. PLoS One (2010) 0.90
Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection. PLoS One (2012) 0.89
Complete genes may pass from food to human blood. PLoS One (2013) 0.87
Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery. J Trauma Acute Care Surg (2015) 0.86
Circulating Tumor Nucleic Acids: Perspective in Breast Cancer. Breast Care (Basel) (2010) 0.85
The struggle to detect circulating DNA. Crit Care (2006) 0.85
Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLoS One (2014) 0.83
Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis. Clin Exp Immunol (2006) 0.81
Fragment size analysis of free fetal DNA in maternal plasma using Y-STR loci and SRY gene amplification. Nagoya J Med Sci (2011) 0.81
The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury. J Trauma Acute Care Surg (2015) 0.81
The impact of chronic kidney disease and short-term treatment with rosiglitazone on plasma cell-free DNA levels. PPAR Res (2014) 0.79
Elevated cell-free plasma DNA level as an independent predictor of mortality in patients with severe traumatic brain injury. J Neurotrauma (2014) 0.78
Cell-free DNA and outcome in sepsis. Crit Care (2012) 0.78
Microbial Recognition and Danger Signals in Sepsis and Trauma. Biochim Biophys Acta (2017) 0.78
The role of cell-free DNA measured by a fluorescent test in the management of isolated traumatic head injuries. Scand J Trauma Resusc Emerg Med (2014) 0.77
Predicting Radiotherapy Responses and Treatment Outcomes Through Analysis of Circulating Tumor DNA. Semin Radiat Oncol (2015) 0.77
Free DNA--new potential analyte in clinical laboratory diagnostics? Biochem Med (Zagreb) (2012) 0.77
Quantitative analysis of plasma HBV DNA for early evaluation of the response to transcatheter arterial embolization for HBV-related hepatocellular carcinoma. World J Gastroenterol (2005) 0.76
Diagnostic potential of circulating cell-free DNA in patients needing mechanical ventilation: promises and challenges. Crit Care (2011) 0.76
Admission cell free DNA as a prognostic factor in burns: quantification by use of a direct rapid fluorometric technique. Biomed Res Int (2014) 0.76
Cell-free DNA increase over first 48 hours in emergency intensive care unit predicts fatal outcome in patients with shock. J Int Med Res (2016) 0.76
Liquid biopsy in early stage lung cancer. Transl Lung Cancer Res (2016) 0.76
An Algorithm Measuring Donor Cell-Free DNA in Plasma of Cellular and Solid Organ Transplant Recipients That Does Not Require Donor or Recipient Genotyping. Front Cardiovasc Med (2016) 0.75
The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review. Crit Care (2017) 0.75
Development and Evaluation of a Duplex Real-Time PCR Assay With a Novel Internal Standard for Precise Quantification of Plasma DNA. Ann Lab Med (2017) 0.75
Circulating nucleic acids: An analysis of their occurrence in malignancies. Biomed Rep (2016) 0.75
Prognostic value of circulating DNA levels in critically ill and trauma patients. Rev Bras Ter Intensiva (2014) 0.75
10. Circulating Nucleic Acids as Diagnostic Tool. EJIFCC (2008) 0.75
Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA. Avicenna J Med Biotechnol (2012) 0.75
Imaging DNA with fluorochrome bearing metals. Inorg Chem (2013) 0.75
Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model. Pediatr Surg Int (2014) 0.75
Assessment of the circulating cell-free DNA marker association with diagnosis and prognostic prediction in patients with lymphoma: a single-center experience. Ann Hematol (2017) 0.75
Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet (1998) 6.88
Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med (1998) 4.29
Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet (1999) 3.39
Capsule endoscopy in acute upper gastrointestinal hemorrhage: a prospective cohort study. Endoscopy (2012) 3.28
Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res (1999) 2.87
Urban hypothermia in the west of Scotland. West of Scotland Accident and Emergency Trainees Research Group. BMJ (1995) 2.29
Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res (1999) 2.19
Classical galactosaemia in Chinese: A case report and review of disease incidence. J Paediatr Child Health (1999) 2.03
Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med (2000) 1.97
Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Cancer Res (1999) 1.82
Acute elbow trauma in children: spectrum of injury revealed by MR imaging not apparent on radiographs. AJR Am J Roentgenol (2001) 1.72
Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21. Clin Chem (1999) 1.65
Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA. Clin Chem (2000) 1.60
Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction. Cancer Res (1999) 1.58
A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene (1999) 1.49
Acute bacterial gastroenteritis: a study of adult patients with positive stool cultures treated in the emergency department. Emerg Med J (2003) 1.44
Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Hum Pathol (1999) 1.43
Paramedic activities, drug administration and survival from out of hospital cardiac arrest. Resuscitation (2000) 1.43
Sonography compared with radiography in revealing acute rib fracture. AJR Am J Roentgenol (1999) 1.42
Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA. Cancer Res (2000) 1.42
Surgical pearl: fine gauze is a useful carrier for epidermal graft in the treatment of vitiligo by means of the suction blister method. J Am Acad Dermatol (1999) 1.40
Theory of telemedicine: the expressivity of the virtual patient. J Telemed Telecare (2000) 1.40
Accidents that should never have happened. When technology to prevent accidents exists it should be used. BMJ (1999) 1.39
Affordable measurement of human total energy expenditure and body composition using one-tenth dose doubly labelled water. Int J Obes (Lond) (2006) 1.38
Analysis of cell-free Epstein-Barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma. Clin Chem (1999) 1.35
Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J Med Genet (2000) 1.34
Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients. Lancet (1998) 1.33
Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience. Radiology (2003) 1.26
EMS systems in China. Resuscitation (2009) 1.25
Telemedicine in China. Int J Med Inform (2001) 1.23
What does London need from its ambulance service? BMJ (1993) 1.20
Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients. Radiology (2003) 1.20
Maternal plasma fetal DNA as a marker for preterm labour. Lancet (1998) 1.16
Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin Chem (2001) 1.12
Plasma cell-free Epstein-Barr virus DNA quantitation in patients with nasopharyngeal carcinoma. Correlation with clinical staging. Ann N Y Acad Sci (2000) 1.12
Leukocyte L-selectin is up-regulated after mechanical trauma in adults. J Trauma (1998) 1.10
Kinetics of plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma. Cancer Res (2000) 1.10
Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. BMJ (2000) 1.09
Age-based formulae to estimate children's weight in the emergency department. Emerg Med J (2010) 1.08
Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy. Br J Haematol (1998) 1.08
Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. Br J Neurosurg (2000) 1.08
Risk assessment of exposure to volatile organic compounds in different indoor environments. Environ Res (2004) 1.07
Indoor air quality at restaurants with different styles of cooking in metropolitan Hong Kong. Sci Total Environ (2001) 1.07
Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease. Radiology (2003) 1.07
Quantitative analysis of circulating cell-free Epstein-Barr virus (EBV) DNA levels in patients with EBV-associated lymphoid malignancies. Br J Haematol (2000) 1.06
Third trimester iron status and pregnancy outcome in non-anaemic women; pregnancy unfavourably affected by maternal iron excess. Hum Reprod (2000) 1.05
Mid-arm circumference can be used to estimate children's weights. Resuscitation (2010) 1.02
EMS systems in Hong Kong. Resuscitation (2009) 0.99
Hepatitis B carrier and perinatal outcome in singleton pregnancy. Am J Perinatol (1999) 0.97
Glycan composition of serum alpha-fetoprotein in patients with hepatocellular carcinoma and non-seminomatous germ cell tumour. Br J Cancer (1999) 0.96
Indoor air quality in ice skating rinks in Hong Kong. Environ Res (2004) 0.96
Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency. Hum Mol Genet (1999) 0.96
Indoor air quality at nine shopping malls in Hong Kong. Sci Total Environ (2001) 0.95
In vitro interaction of aminoglycosides with beta-lactam penicillins. Antimicrob Agents Chemother (1985) 0.95
Characterization of ambient volatile organic compounds at a landfill site in Guangzhou, South China. Chemosphere (2003) 0.94
The role of telenursing in the provision of geriatric outreach services to residential homes in Hong Kong. J Telemed Telecare (2001) 0.94
Predicting massive blood transfusion using clinical scores post-trauma. Vox Sang (2011) 0.93
Bicycle related injuries presenting to a trauma centre in Hong Kong. Injury (2009) 0.93
On site medical services at major incidents. BMJ (1992) 0.90
Predictors of important neurological causes of dizziness among patients presenting to the emergency department. Emerg Med J (2010) 0.88
Human liver regeneration: hepatic energy economy is less efficient when the organ is diseased. Hepatology (2001) 0.88
One-step solid-phase extraction procedure for F(2)-isoprostanes. Clin Chem (2001) 0.88
Do peripheral blood counts have any prognostic value following trauma? Injury (1999) 0.87
Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax (2005) 0.87
Emergency medicine in Hong Kong. Hong Kong Med J (2000) 0.86
Left ventricular diastolic function during normal pregnancy: assessment by spectral tissue Doppler imaging. Ultrasound Obstet Gynecol (2006) 0.86
The management of epistaxis in accident and emergency departments: a survey of current practice. Arch Emerg Med (1990) 0.86
Differences in the compliance with hospital infection control practices during the 2009 influenza H1N1 pandemic in three countries. J Hosp Infect (2012) 0.85
Clinical evaluation of ceftibuten in gonorrhea. A pilot study in Hong Kong. Sex Transm Dis (1998) 0.85
Establishment and characterization of a human cell line from paediatric cerebellar glioblastoma multiforme. Neuropathol Appl Neurobiol (2000) 0.85
Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs. Cancer Immunol Immunother (1997) 0.84
Structures of disease-specific serum alpha-fetoprotein isoforms. Br J Cancer (2000) 0.84
Risk of miscarriage in pregnant users of NSAIDs. More information is needed to be able to interpret study's results. BMJ (2001) 0.83
Circulating Epstein-Barr virus DNA in the serum of patients with gastric carcinoma. Clin Cancer Res (2001) 0.83
Disease severity prediction for nursing home-acquired pneumonia in the emergency department. Emerg Med J (2011) 0.82
Determination of fetal RhD status by maternal plasma DNA analysis. Ann N Y Acad Sci (2000) 0.82
Influenza virus load in hospitalised patients. Hong Kong Med J (2013) 0.82
Computed tomography for cervical spine trauma. The impact of MDCT on fracture detection and dose deposition. Emerg Radiol (2005) 0.81
Derivation of a prediction rule for posttraumatic organ failure using plasma DNA and other variables. Ann N Y Acad Sci (2001) 0.81
A survey of physicians' acceptance of telemedicine. J Telemed Telecare (1998) 0.81
Emergency department intervention for high-risk elders: identification strategy and randomised controlled trial to reduce hospitalisation and institutionalisation. Hong Kong Med J (2011) 0.81
Cure of malignant ascites and generation of protective immunity by monoclonal antibody-targeted activation of a glucuronide prodrug in rats. Int J Cancer (1997) 0.81
Surface ozone trends in Hong Kong in 1985-1995. Environ Int (2001) 0.81
Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther (2001) 0.81
Adrenaline upregulates monocyte L-selectin in vitro. Resuscitation (1999) 0.81
Differentiation of a human eosinophilic leukemic cell line, EoL-1: characterization by the expression of cytokine receptors, adhesion molecules, CD95 and eosinophilic cationic protein (ECP). Immunol Lett (1999) 0.81
Derivation of a prediction rule for post-traumatic acute lung injury. Resuscitation (1999) 0.80
Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues. Hum Reprod (2005) 0.80
Role of monocyte L-selectin in the development of post-traumatic organ failure. Resuscitation (2001) 0.80
Treatment of vitiligo with autologous epidermal transplantation using the roofs of suction blisters. Hong Kong Med J (1998) 0.79
Cost-effectiveness of Dermabond versus sutures for lacerated wound closure: a randomised controlled trial. Hong Kong Med J (2011) 0.79
Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury. Nephrol Dial Transplant (2001) 0.79
Primary plasmalemmal carnitine transporter defect manifested with dicarboxylic aciduria and impaired fatty acid oxidation. J Inherit Metab Dis (1998) 0.79
Circulating nucleic acid analysis: diagnostic applications for acute pathologies. Acta Neurochir Suppl (2005) 0.79