Published in Toxicon on July 01, 2000
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons. Toxicol Sci (2009) 1.43
Neurotoxins from marine dinoflagellates: a brief review. Mar Drugs (2008) 1.40
Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts. Mar Drugs (2008) 1.08
Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization. Org Lett (2002) 1.05
Marine toxins: chemistry, toxicity, occurrence and detection, with special reference to the Dutch situation. Toxins (Basel) (2010) 1.00
Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons. Toxicol Sci (2010) 0.91
Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels. Chem Res Toxicol (2012) 0.88
Synthesis of the ABCD and ABCDE ring systems of azaspiracid-1. Chem Commun (Camb) (2004) 0.88
New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish. Sci Rep (2015) 0.83
Azaspiracid substituent at C1 is relevant to in vitro toxicity. Chem Res Toxicol (2008) 0.83
In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats. Arch Toxicol (2013) 0.82
Risk assessment of shellfish toxins. Toxins (Basel) (2013) 0.81
Monoclonal antibodies with orthogonal azaspiracid epitopes. Chembiochem (2009) 0.79
Synthetic and Computational Studies on the ABC Trioxadispiroketal Subunit of the Marine Biotoxin Azaspiracid-1. Nat Prod Commun (2008) 0.78
Toxic marine microalgae and shellfish poisoning in the British isles: history, review of epidemiology, and future implications. Environ Health (2011) 0.76
Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats. Toxicol Sci (2016) 0.76
In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. Toxicon (2014) 0.76
Combined Effects of Lipophilic Phycotoxins (Okadaic Acid, Azapsiracid-1 and Yessotoxin) on Human Intestinal Cells Models. Toxins (Basel) (2016) 0.76
Microsphere-based immunoassay for the detection of azaspiracids. Anal Biochem (2013) 0.75
Algal Toxin Azaspiracid-1 Induces Early Neuronal Differentiation and Alters Peripherin Isoform Stoichiometry. Mar Drugs (2015) 0.75
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
BioJava: an open-source framework for bioinformatics. Bioinformatics (2008) 6.17
Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J Natl Cancer Inst (2000) 5.62
PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A (1993) 4.05
Size and shape in biology. Science (1973) 3.71
Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology (1993) 3.37
A role for hematopoietic stem cells in promoting angiogenesis. Cell (2000) 3.25
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron (1999) 2.82
Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol (1999) 2.77
Anti-lymphocytic antibody--a review. Clin Exp Immunol (1967) 2.75
Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J Virol (1990) 2.69
Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene (1993) 2.67
The Runt domain identifies a new family of heteromeric transcriptional regulators. Trends Genet (1993) 2.65
Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet (1998) 2.47
BCG immunotherapy of bladder cancer: 20 years on. Lancet (1999) 2.38
Respiratory syncytial virus envelope glycoprotein (G) has a novel structure. Nucleic Acids Res (1985) 2.37
PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol Cell Biol (1994) 2.27
Human monoclonal antibody production. Current status and future prospects. J Immunol Methods (1987) 2.21
Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon. Nat Neurosci (1999) 2.17
Laboratory staff qualifications and accuracy of proficiency test results. A national study. Arch Pathol Lab Med (1992) 2.07
Who provides patients with drug information? Br Med J (Clin Res Ed) (1987) 2.04
The natural history of Peyronie's disease. J Urol (1990) 2.02
Taxonomy of four marine bacterial strains that produce tetrodotoxin. Int J Syst Bacteriol (1990) 1.91
Analysis of donor criteria for the prediction of outcome in clinical liver transplantation. Transplant Proc (1987) 1.90
Effect of antilymphocytic antibody and antibody fragments on human lymphocytes in vitro. Nature (1967) 1.89
A precision measurement of the mass of the top quark. Nature (2004) 1.87
Total synthesis of ciguatoxin CTX3C. Science (2001) 1.80
Psychotic men remanded in custody to Brixton Prison. Br J Psychiatry (1994) 1.77
Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal shunts. Radiology (1997) 1.74
Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies. Br Med J (Clin Res Ed) (1983) 1.72
Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. Gene (1995) 1.71
HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. Tissue Antigens (1984) 1.71
Long-term follow-up confirms a survival advantage of the paclitaxel-cisplatin regimen over the cyclophosphamide-cisplatin combination in advanced ovarian cancer. Int J Gynecol Cancer (2003) 1.70
International survey on NAT testing of blood donations: expanding implementation and yield from 1999 to 2009. Vox Sang (2011) 1.69
Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit. Nucleic Acids Res (1985) 1.69
AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene (1998) 1.67
Radio-immunoassay detection of interferon-gamma in urine after intravesical Evans BCG therapy. J Urol (1990) 1.66
Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells. Genes Cells (2001) 1.65
Randomized study of CODE versus alternating CAV/EP for extensive-stage small-cell lung cancer: an Intergroup Study of the National Cancer Institute of Canada Clinical Trials Group and the Southwest Oncology Group. J Clin Oncol (1999) 1.63
Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts. J AOAC Int (1995) 1.63
Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci U S A (1997) 1.62
A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae. Genetics (2008) 1.58
Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut (2004) 1.58
Some factors influencing the ability of anti-lymphocytic antibody to suppress humoral antibody formation. Clin Exp Immunol (1967) 1.52
Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma. J Clin Oncol (2002) 1.50
Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci (2001) 1.49
The preparation and properties of anti-lymphocytic sera. Prog Surg (1969) 1.48
Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood (1995) 1.48
Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. Toxicon (1987) 1.47
[Surgical treatment of the single non traumatic perforation of small bowel: excision-suture or resection-anastomosis]. Ann Chir (2005) 1.45
Melatonin administration can entrain the free-running circadian system of blind subjects. J Endocrinol (2000) 1.43
Construction of murine coronavirus mutants containing interspecies chimeric nucleocapsid proteins. J Virol (1995) 1.43
Structure-property correlations in a combinatorial library of degradable biomaterials. J Biomed Mater Res (1998) 1.42
Continuous thoracic epidural analgesia versus combined spinal/thoracic epidural analgesia on pain, pulmonary function and the metabolic response following colonic resection. Acta Anaesthesiol Scand (1996) 1.42
Effect of antilymphocytic antibody and antibody fragments on skin-homograft survival and the blood-lymphocyte count in rats. Lancet (1967) 1.41
Effect of anti-rat lymphocyte antibody on humoral antibody formation. Nature (1967) 1.40
The nuclear protooncogenes c-jun and c-fos as regulators of DNA replication. Proc Natl Acad Sci U S A (1991) 1.40
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat Toxins (1999) 1.38
Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J Urol (1992) 1.38
Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol Cell Biol (1995) 1.38
Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents. Nature (1994) 1.37
Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol (1996) 1.32
Nucleotide sequence of the gene encoding respiratory syncytial virus matrix protein. J Virol (1984) 1.31
The structure elucidation and biological activities of high molecular weight algal toxins: maitotoxin, prymnesins and zooxanthellatoxins. Nat Prod Rep (2000) 1.31
A randomised controlled study of an audiovisual patient information intervention on informed consent and recruitment to cancer clinical trials. Br J Cancer (2007) 1.30
New saxitoxin analogues from the freshwater filamentous cyanobacterium Lyngbya wollei. Nat Toxins (1997) 1.28
A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors. Cell Growth Differ (1990) 1.27
Characterization of antilymphocytic antibody. Nature (1967) 1.27
Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci U S A (1994) 1.27
Quality-adjusted time without symptoms or toxicity analysis of interferon maintenance in multiple myeloma. J Clin Oncol (1998) 1.27
Characterization of symptomatic and asymptomatic carotid plaques using high-resolution real-time ultrasonography. Br J Surg (1993) 1.26
The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK-1. Clin Exp Immunol (1983) 1.25
Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe. Biosci Biotechnol Biochem (2001) 1.20
New allele at cholinesterase locus 1. J Med Genet (1976) 1.20
Isolation and characterization of NIH 3T3 cells expressing polyomavirus small T antigen. J Virol (1986) 1.18
Normal and pathological serum levels of alpha2-macroglobulins in men and mice. J Clin Pathol (1975) 1.18
Bacterial contamination in platelet concentrates. Vox Sang (2014) 1.18
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship. Biochem J (1992) 1.18
Maitotoxin, a Ca2+ channel activator candidate. J Biol Chem (1982) 1.18
First occurrence of tetrodotoxin in a dendrobatid frog (Colostethus inguinalis), with further reports for the bufonid genus Atelopus. Toxicon (1994) 1.17
A factor discriminating between the wild-type and a mutant polyomavirus enhancer. Nature (1987) 1.16
A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon (1996) 1.16
Prolongation of canine renal allograft survival with antilymphocytic serum. Transplantation (1968) 1.16
Comparison of oral and intraperitoneal toxicity of yessotoxin towards mice. Toxicon (2002) 1.16
Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics. J Clin Invest (1985) 1.15
The effect of anti-lymphocytic antibody on the humoral immune response in different strains of mice. I. The response to bovine serum albumin. Immunology (1972) 1.15
Changes in urinary cytokines and soluble intercellular adhesion molecule-1 (ICAM-1) in bladder cancer patients after bacillus Calmette-Guérin (BCG) immunotherapy. Clin Exp Immunol (1995) 1.14
Flexible eating and flexible insulin dosing in patients with diabetes: Results of an intensive self-management course. Diabetes Res Clin Pract (2008) 1.13
Quantitative studies with antilymphocytic antibody. Nature (1967) 1.13
Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury. Transfus Med (2007) 1.12
Development of pseudolymphoma of liver following interferon-alpha therapy for chronic hepatitis B. Intern Med (1994) 1.12
Tertiary structure of conotoxin GIIIA in aqueous solution. Biochemistry (1991) 1.12
Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb. Curr Biol (1999) 1.12