Published in J Natl Cancer Inst on April 05, 2000
Metapopulation dynamics and spatial heterogeneity in cancer. Proc Natl Acad Sci U S A (2002) 2.17
Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer. Gut (2005) 1.87
Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study. Gastroenterology (2008) 1.69
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int J Cancer (2013) 1.60
An economic viewpoint on alternative strategies for identifying persons with hereditary nonpolyposis colorectal cancer. Genet Med (2003) 1.18
Predictive and prognostic value of microsatellite instability in patients with advanced colorectal cancer treated with a fluoropyrimidine and oxaliplatin containing first-line chemotherapy. A report of the AIO Colorectal Study Group. Int J Colorectal Dis (2008) 1.10
Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br J Cancer (2009) 1.08
Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature. Int J Colorectal Dis (2003) 1.07
The immunogenicity of colorectal cancers with high-degree microsatellite instability. World J Surg Oncol (2005) 1.01
A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol (2012) 1.00
Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes? Mutat Res (2012) 0.93
Biological significance of microsatellite instability-low (MSI-L) status in colorectal tumors. Am J Pathol (2001) 0.87
Organochlorine exposure and colorectal cancer risk. Environ Health Perspect (2004) 0.85
Gene Signatures in Stage II Colon Cancer: A Clinical Review. Curr Colorectal Cancer Rep (2012) 0.82
Assessment of three generations of mice derived by ICSI using freeze-dried sperm. Zygote (2009) 0.81
Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy. J Clin Pathol (2005) 0.79
Microsatellite instability, clinical implications, and new methodologies. J Natl Cancer Inst (2000) 0.77
Prognostic values of chromosome 18q microsatellite alterations in stage II colonic carcinoma. World J Gastroenterol (2010) 0.75
Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst (1995) 18.86
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet (2000) 12.56
Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax (2005) 7.39
The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med (2001) 5.95
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet (1998) 4.16
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nat Neurosci (1999) 3.45
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res (2000) 2.99
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet (1994) 2.95
An anorexic lipid mediator regulated by feeding. Nature (2001) 2.94
A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria. Proc Natl Acad Sci U S A (2001) 2.88
Renal injury in the extremely obese patients with normal renal function. Kidney Int (2008) 2.83
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res (2000) 2.79
Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med (1998) 2.68
Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science (1997) 2.50
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet (2001) 2.50
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol (2001) 2.48
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res (2001) 1.97
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res (2000) 1.95
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int J Cancer (1994) 1.82
A randomized phase III study comparing adjuvant 5-fluorouracil/folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. Ann Oncol (2009) 1.81
International trends in incidence of cervical cancer: II. Squamous-cell carcinoma. Int J Cancer (2000) 1.79
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res (2000) 1.73
High-resolution PLA-based composite scaffolds via 3-D printing technology. Acta Biomater (2012) 1.67
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer (2009) 1.62
International trends in the incidence of cervical cancer: I. Adenocarcinoma and adenosquamous cell carcinomas. Int J Cancer (1998) 1.56
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance. J Clin Oncol (1999) 1.53
International collaborative study on standardization of bacterial sensitivity to fosfomycin. J Antimicrob Chemother (1983) 1.52
Brief report: melatonin-related hypogonadotropic hypogonadism. N Engl J Med (1992) 1.48
Phylogeography of the Calonectris shearwaters using molecular and morphometric data. Mol Phylogenet Evol (2006) 1.47
The comparison of two gonadotropin-releasing hormone agonists in an in vitro fertilization program. Fertil Steril (1992) 1.46
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer. Eur J Gastroenterol Hepatol (2001) 1.46
alpha-Interferon therapy for congenital dyserythropoiesis type I. Br J Haematol (1995) 1.46
Technical improvements in corrosion casting of small specimens: a study on mesonephric tubules and vessels of chicken embryos. Scanning Microsc (1993) 1.39
Reengineering respiratory support following extubation: avoidance of critical care unit costs. Chest (1999) 1.39
Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in Spain. Emerg Infect Dis (1996) 1.39
[Study of 164 episodes of infectious endocarditis in drug addicts: comparison of HIV positive and negative patients]. Rev Clin Esp (1994) 1.38
[Rapid and slow progression of the infection by the type 1 human immunodeficiency virus in a population of seropositive subjects in Madrid]. Med Clin (Barc) (1996) 1.38
Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women. Br J Cancer (2009) 1.37
Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008. Nutr Metab Cardiovasc Dis (2010) 1.36
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res (1999) 1.33
Risk excess of soft-tissue sarcoma and thyroid cancer in a community exposed to airborne organochlorinated compound mixtures with a high hexachlorobenzene content. Int J Cancer (1994) 1.33
Survival after liver transplantation in cirrhotic patients with and without hepatocellular carcinoma: a comparative study. Hepatology (1997) 1.31
Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. J Neurosci (2000) 1.31
Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis (2005) 1.31
Endoscopic, bioptic, and manometric findings in eosinophilic esophagitis before and after steroid therapy: a case series. Endoscopy (2007) 1.27
Chagas disease in Latin American migrants: a Spanish challenge. Clin Microbiol Infect (2010) 1.27
Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer (2004) 1.27
Diagnosis of visceral leishmaniasis in HIV-infected individuals using peripheral blood smears. AIDS (1993) 1.23
Safety of dobutamine-atropine stress echocardiography: A prospective experience of 4,033 consecutive studies. J Am Soc Echocardiogr (1999) 1.20
Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy. Br J Cancer (2008) 1.19
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene (1999) 1.19
Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting. Cancer Genet Cytogenet (2000) 1.19
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. Ann Oncol (2006) 1.18
The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427. Mol Biochem Parasitol (2000) 1.16
p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood (1996) 1.16
Ecstasy: a common cause of severe acute hepatotoxicity. J Hepatol (1998) 1.13
Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology (2004) 1.13
p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol (1999) 1.13
Systemic lupus erythematosus in the elderly: clinical and immunological characteristics. Ann Rheum Dis (1991) 1.12
A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. Br J Cancer (2010) 1.11
Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats. Metabolism (2000) 1.11
Regulation of vsg expression site transcription and switching in Trypanosoma brucei. Mol Biochem Parasitol (1998) 1.11
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. Cancer Res (2001) 1.11
Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP). Oncogene (2001) 1.10
Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates. AIDS Res Hum Retroviruses (1994) 1.10
[Some methodological aspects of age-period-cohort models. Application to cancer mortality trends]. Gac Sanit (2002) 1.10
UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. Br J Cancer (2010) 1.10
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer. J Clin Oncol (2001) 1.09
Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium- and rhodium-chloroquine complexes. J Med Chem (1996) 1.09
DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma. Cancer Genet Cytogenet (2000) 1.09
Pd(II) and Pt(II) complexes with aromatic diamines: study of their interaction with DNA. J Inorg Biochem (2004) 1.09
Leukemia-associated changes identified by quantitative flow cytometry. II. CD5 over-expression and monitoring in B-CLL. Leukemia (1994) 1.09
Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br J Cancer (2009) 1.08
Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells. J Biol Chem (2000) 1.08
Diet and colorectal adenomas: a case-control study in Majorca. Int J Cancer (1993) 1.08
Inverse paradoxical embolism in a patient on chronic hemodialysis with aortic bacterial endocarditis. Am J Kidney Dis (1999) 1.07
Refinement of the Medicare diagnosis-related groups to incorporate a measure of severity. Health Care Financ Rev (1994) 1.05
New tubulins in protozoal parasites. Curr Biol (2000) 1.05
Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. Am J Epidemiol (2009) 1.05
Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats. J Pharmacol Exp Ther (1996) 1.04
Posterior urethral valves: prognostic factors. BJU Int (2003) 1.04
Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience (2003) 1.03
Obesity, adiponectin and inflammation as predictors of new-onset diabetes mellitus after kidney transplantation. Am J Transplant (2007) 1.03
The role of free radicals in cerebral hypoxia and ischemia. Free Radic Biol Med (2005) 1.03