The cytotoxic enterotoxin of Aeromonas hydrophila induces proinflammatory cytokine production and activates arachidonic acid metabolism in macrophages.

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Published in Infect Immun on May 01, 2000

Authors

A K Chopra1, X Xu, D Ribardo, M Gonzalez, K Kuhl, J W Peterson, C W Houston

Author Affiliations

1: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. achopra@utmb.edu

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Cloning, expression, and sequence analysis of a cytolytic enterotoxin gene from Aeromonas hydrophila. Can J Microbiol (1993) 1.51

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