Synthesis and GABA(A) receptor activity of 6-oxa-analogs of neurosteroids.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 10802285)

Published in Steroids on June 01, 2000

Authors

D Nicoletti1, A A Ghini, R Furtmüller, W Sieghart, R H Dodd, G Burton

Author Affiliations

1: Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de, Buenos Aires, Argentina.

Articles citing this

Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60

Articles by these authors

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience (2000) 5.81

Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci (1998) 4.50

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev (1998) 4.37

Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol (2000) 4.03

Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A (1999) 2.88

Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol (2002) 2.55

Stoichiometry and assembly of a recombinant GABAA receptor subtype. J Neurosci (1997) 2.35

GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience (1997) 2.27

Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci (1997) 2.08

Effect of vaginal ultrasound probe on lower urinary tract function. Br J Urol (1992) 2.04

Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. Proc Natl Acad Sci U S A (1996) 2.04

Prognostic factors in patients with advanced hepatocellular carcinoma treated with sorafenib. Aliment Pharmacol Ther (2011) 1.85

Anatomical gradients in proliferation and differentiation of embryonic rat CNS accessed by buoyant density fractionation: alpha 3, beta 3 and gamma 2 GABAA receptor subunit co-expression by post-mitotic neocortical neurons correlates directly with cell buoyancy. Eur J Neurosci (1997) 1.70

The effects of sorafenib on the portal hypertensive syndrome in patients with liver cirrhosis and hepatocellular carcinoma--a pilot study. Aliment Pharmacol Ther (2011) 1.54

Ca2+ and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue. Proc Natl Acad Sci U S A (1979) 1.53

Efficacy of oral ondansetron, a selective antagonist of 5-HT3 receptors, in the treatment of nausea and vomiting associated with cyclophosphamide-based chemotherapies. Ondansetron Study Group. Am J Clin Oncol (1994) 1.53

GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. J Biol Chem (2000) 1.50

Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord. J Neurosci (1996) 1.49

Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J Neurochem (1997) 1.49

Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits. J Neurosci (1998) 1.48

The citalopram challenge test in patients with major depression and in healthy controls. Psychiatry Res (1999) 1.45

Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Science (1980) 1.44

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption. J Clin Invest (1997) 1.42

Problems of recruiting ovum donors. Br J Hosp Med (1990) 1.38

Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation. Am J Obstet Gynecol (2001) 1.34

Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks. Nature (1986) 1.33

Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol (2005) 1.32

Functional correlation of GABA(A) receptor alpha subunits expression with the properties of IPSCs in the developing thalamus. J Neurosci (2000) 1.30

Distribution of the major gamma-aminobutyric acid(A) receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol (2001) 1.30

A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits. J Biol Chem (1999) 1.29

Regulation of placental efficiency for nutrient transport by imprinted genes. Placenta (2006) 1.29

GABA(A) receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy. Neuroscience (1997) 1.27

Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites. J Comp Neurol (2000) 1.27

Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience (2002) 1.23

GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy. Neuroscience (1997) 1.22

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Curr Med Chem (2007) 1.22

Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell. Nature (1978) 1.19

Comparative modeling of GABA(A) receptors: limits, insights, future developments. Neuroscience (2003) 1.18

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain. Neuroscience (2013) 1.17

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice. J Psychopharmacol (2011) 1.16

Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus. Eur J Neurosci (1995) 1.16

Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. Eur J Neurosci (1999) 1.16

The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology (1996) 1.14

Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. J Biol Chem (2001) 1.13

Dual inhibition of EGFR and mTOR pathways in small cell lung cancer. Br J Cancer (2010) 1.06

Molecular heterogeneity of benzodiazepine receptors. Nature (1980) 1.05

GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl- channels. J Neurosci (2001) 1.05

Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacology (2004) 1.05

Differential regulation of GABA(A) receptor gene expression by ethanol in the rat hippocampus versus cerebral cortex. J Neurochem (1998) 1.05

GABA(A) receptor assembly. Identification and structure of gamma(2) sequences forming the intersubunit contacts with alpha(1) and beta(3) subunits. J Biol Chem (2000) 1.05

Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology (2000) 1.05

Age, pregnancy and miscarriage: uterine versus ovarian factors. Hum Reprod (1993) 1.04

Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology (2002) 1.04

Effects of low dose endotoxemia on endothelial progenitor cells in humans. Atherosclerosis (2007) 1.02

Copper-catalyzed nitrogen transfer mediated by iodosylbenzene PhI=O. J Am Chem Soc (2001) 1.01

Differential regulation of synaptic GABAA receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones. J Physiol (1999) 1.01

Affinity of various ligands for benzodiazepine receptors in rat cerebellum and hippocampus. Biochem Pharmacol (1984) 1.01

The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J Neurosci (1996) 1.00

Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity. J Biol Chem (2000) 1.00

Matching of antibiotic resistance patterns of Escherichia coli of farm families and their animals. J Infect Dis (1974) 1.00

Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation. Pharmacol Biochem Behav (1987) 1.00

Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. Eur J Neurosci (2005) 1.00

Composition of the GABA(A) receptors of retinal dopaminergic neurons. J Neurosci (1999) 0.99

No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry (2001) 0.99

Neuronal localization of specific brain phosphoproteins. Brain Res (1978) 0.99

The expression and function of Ca(2+)-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br J Pharmacol (2008) 0.98

Multiplicity of GABAA--benzodiazepine receptors. Trends Pharmacol Sci (1989) 0.98

Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. J Comp Neurol (1999) 0.98

In-vivo measurement of intrauterine gases and acid-base values early in human pregnancy. Hum Reprod (1999) 0.97

Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors. Mol Pharmacol (1995) 0.96

Various proteins from rat brain, specifically and irreversibly labeled by [3H]flunitrazepam, are distinct alpha-subunits of the GABA-benzodiazepine receptor complex. Neurosci Lett (1988) 0.96

Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. Mol Cell Neurosci (2000) 0.96

Alternate use of distinct intersubunit contacts controls GABAA receptor assembly and stoichiometry. J Neurosci (2001) 0.95

Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy. Breast Cancer Res Treat (2003) 0.95

A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry (2003) 0.94

Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta (2010) 0.94

Antibodies specific for GABAA receptor alpha subunits reveal that chronic alcohol treatment down-regulates alpha-subunit expression in rat brain regions. J Neurochem (1993) 0.94

Photoaffinity labeling of benzodiazepine receptor proteins with the partial inverse agonist [3H]Ro 15-4513: a biochemical and autoradiographic study. J Neurochem (1987) 0.92

GABA influences the development of the ventromedial nucleus of the hypothalamus. J Neurobiol (2001) 0.92

Synaptic control of glycine and GABA(A) receptors and gephyrin expression in cultured motoneurons. J Neurosci (1999) 0.92

Biokinetics in humans of RRR-alpha-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamin E. Free Radic Biol Med (1995) 0.92

Human chorionic gonadotrophin release and tissue viability in placental organ culture. Hum Reprod (1995) 0.92

Immunohistochemical localization of the alpha 1, alpha 2 and alpha 3 subunit of the GABAA receptor in the rat brain. Neurosci Lett (1991) 0.91

A rapid and simple method for efficient coating of microtiter plates using low amounts of antigen in the presence of detergent. J Immunol Methods (1986) 0.91

Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of beta-lapachone. J Med Chem (2001) 0.91

A rapid direct assay for uroporphyrinogen III cosynthetase. FEBS Lett (1980) 0.90

Clusters of GABAA receptors on cultured hippocampal cells correlate only partially with functional synapses. Eur J Neurosci (1999) 0.90

Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience (1999) 0.90

Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography. Brain Res (1991) 0.89

HIV-HCV co-infected patients with low CD4+ cell nadirs are at risk for faster fibrosis progression and portal hypertension. J Viral Hepat (2009) 0.89

Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of pregnanesteroids. Mol Cell Endocrinol (2004) 0.89

Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. Eur J Pharmacol (1996) 0.89

Differential localization of GABA(A) receptor subunits in relation to rat striatopallidal and pallidopallidal synapses. Eur J Neurosci (2011) 0.89

Possible association between childhood absence epilepsy and the gene encoding GABRB3. Biol Psychiatry (1999) 0.89

An open study of the bladder neck support prosthesis in genuine stress incontinence. Br J Obstet Gynaecol (1999) 0.89

Naphthylamidase activity of Leptospira. Appl Microbiol (1970) 0.89

Extensive heterogeneity of recombinant gamma-aminobutyric acidA receptors expressed in alpha 4 beta 3 gamma 2-transfected human embryonic kidney 293 cells. Neuropharmacology (1996) 0.89

Evidence for the existence of several different alpha- and beta-subunits of the GABA/benzodiazepine receptor complex from rat brain. Neurosci Lett (1989) 0.88

No association of clock gene T3111C polymorphism and affective disorders. Eur Neuropsychopharmacol (2005) 0.88